AutismKB 2.0

Annotation Detail for FLNC


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Basic Information Top
Gene Symbol:FLNC ( ABP-280,ABP280A,ABPA,ABPL,FLJ10186,FLN2 )
Gene Full Name: filamin C, gamma
Band: 7q32.1
Quick LinksEntrez ID:2318; OMIM: 102565; Uniprot ID:FLNC_HUMAN; ENSEMBL ID: ENSG00000128591; HGNC ID: 3756
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body32 / 70761452
blastocyst2 / 6231932
fetus36 / 56401263
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult113 / 193912158
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma4 / 8282348
colorectal tumor8 / 11424670
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor16 / 26384560
glioma2 / 10688318
head and neck tumor12 / 13630288
kidney tumor10 / 68959145
leukemia1 / 9584210
liver tumor10 / 96359103
lung tumor4 / 10312738
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal187 / 336030755
ovarian tumor2 / 7668226
pancreatic tumor69 / 104616659
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer3 / 10268029
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder1 / 2975733
blood1 / 1234788
bone1 / 7165513
bone marrow0 / 488010 
brain35 / 110098931
cervix0 / 481710 
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue41 / 215722190
esophagus0 / 202090 
eye7 / 21105433
heart14 / 89626156
intestine22 / 23447293
kidney17 / 21177780
larynx7 / 24145289
liver13 / 20774362
lung22 / 33697465
lymph0 / 442700 
lymph node0 / 916100 
mammary gland1 / 1532716
mouth1 / 6705214
muscle45 / 107715417
nerve2 / 15768126
ovary5 / 10205148
pancreas69 / 214812321
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta1 / 2808253
prostate15 / 18934579
salivary gland4 / 20155198
skin4 / 21057418
spleen0 / 539520 
stomach3 / 9661931
testis8 / 33044224
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord0 / 136800 
uterus15 / 23287864
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 207876_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts8
Adipocyte9.6
AdrenalCortex9.55
Adrenalgland7.6
Amygdala6.05
Appendix14.85
AtrioventricularNode5
BDCA4+_DentriticCells7.2
Bonemarrow9.1
BronchialEpithelialCells6.45
CD105+_Endothelial6.65
CD14+_Monocytes7.05
CD19+_BCells(neg._sel.)6.9
CD33+_Myeloid6.95
CD34+7.3
CD4+_Tcells7.15
CD56+_NKCells7.75
CD71+_EarlyErythroid6.15
CD8+_Tcells6.35
CardiacMyocytes17.2
Caudatenucleus5.9
Cerebellum5.3
CerebellumPeduncles8.2
CiliaryGanglion8.85
CingulateCortex6.95
Colorectaladenocarcinoma6.6
DorsalRootGanglion5.1
FetalThyroid132.15
Fetalbrain6.55
Fetalliver5.65
Fetallung8.5
GlobusPallidus7.65
Heart294.5
Hypothalamus7.85
Kidney5.3
Leukemia_chronicMyelogenousK-56224.7
Leukemia_promyelocytic-HL-605.8
Leukemialymphoblastic(MOLT-4)5.25
Liver8.5
Lung12.3
Lymphnode5.7
Lymphoma_burkitts(Daudi)8.4
Lymphoma_burkitts(Raji)9.1
MedullaOblongata6
OccipitalLobe5.9
OlfactoryBulb7.3
Ovary4.35
Pancreas8.65
PancreaticIslet7.05
ParietalLobe6.9
Pituitary10.85
Placenta6.9
Pons6.7
PrefrontalCortex8.15
Prostate46.95
Salivarygland5.25
SkeletalMuscle372.25
Skin5.25
SmoothMuscle36
Spinalcord23.1
SubthalamicNucleus7.8
SuperiorCervicalGanglion7.35
TemporalLobe7.45
Testis6.15
TestisGermCell10.4
TestisIntersitial5.55
TestisLeydigCell6.75
TestisSeminiferousTubule6.15
Thalamus7.9
Thymus5.25
Thyroid16.45
Tongue36.4
Tonsil7.5
Trachea11.5
TrigeminalGanglion9.3
Uterus121.25
UterusCorpus6.35
WholeBlood7.2
Wholebrain5.6
colon18.35
pineal_day8.16
pineal_night7.36
retina16.15
small_intestine16.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P77968
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.05 ± 1.08
Basal Forebrain3.31 ± 0.48
Basal Part of Pons3.45 ± 0.81
Cerebellar Cortex2.7 ± 0.58
Cerebellar Nuclei3.77 ± 1.13
Claustrum3.81 ± 0.92
Epithalamus4.86 ± 0.54
Frontal Lobe3.1 ± 0.81
Globus Pallidus4.66 ± 0.45
Hypothalamus3.19 ± 1.17
Insula2.41 ± 0.58
Limbic Lobe3.06 ± 0.84
Mesencephalon3.58 ± 0.8
Myelencephalon3.39 ± 0.84
Occipital Lobe3.52 ± 0.95
Parietal Lobe3.27 ± 0.99
Pontine Tegmentum3.18 ± 0.82
Striatum3.53 ± 0.81
Subthalamus3.05 ± 0.49
Temporal Lobe3.07 ± 0.8
Thalamus3.33 ± 0.56
White Matter6.04 ± 0.55
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
FlncCBCerebellum9.74
11.49
FlncCTXCerebral cortex19.3
13.77
FlncHIPHippocampal region10.13
9.72
FlncHPFHippocampal formation13.82
12.19
FlncHYHypothalamus7.57
5.8
FlncLSXLateral septal complex1.02
0.71
FlncMBMidbrain5.62
5.31
FlncMYMedulla13.6
14.27
FlncOLFOlfactory bulb24.1
18.53
FlncPPons10.64
11.94
FlncPALPallidum8.85
6.79
FlncRHPRetrohippocampal region20.29
15.85
FlncsAMYStriatum-like amygdalar nuclei9.81
6.59
FlncSTRStriatum6.47
4.41
FlncSTRdStriatum dorsal region5.42
3.65
FlncSTRvStriatum ventral region11.52
7.71
FlncTHThalamus7.43
5.99
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
FLNC_HUMAN_1010 18 1010 1027 PIPCKLEPGGGAEAQAVR PRIDE
FLNC_HUMAN_1073 15 1073 1087 GGLVGTPAPFSIDTK PRIDE
FLNC_HUMAN_1088 18 1088 1105 GAGTGGLGLTVEGPCEAK PRIDE
FLNC_HUMAN_1241 13 1241 1253 VHVQPAVDTSGVK PRIDE
FLNC_HUMAN_1267 11 1267 1277 EVTTEFTVDAR PRIDE
FLNC_HUMAN_1278 13 1278 1290 SLTATGGNHVTAR PRIDE
FLNC_HUMAN_1341 11 1341 1351 VGVTEGCDPTR PRIDE
FLNC_HUMAN_1354 13 1354 1366 AFGPGLEGGLVNK PRIDE
FLNC_HUMAN_1376 18 1376 1393 GAGTGGLGLAIEGPSEAK PRIDE
FLNC_HUMAN_1460 14 1460 1473 VPQTFTVDCSQAGR PRIDE
FLNC_HUMAN_1474 20 1474 1493 APLQVAVLGPTGVAEPVEVR PRIDE
FLNC_HUMAN_1543 24 1543 1566 ASGPGLNASGIPASLPVEFTIDAR PRIDE
FLNC_HUMAN_1615 12 1615 1626 YGGDEIPYSPFR PRIDE
FLNC_HUMAN_1638 19 1638 1656 CLVTVSIGGHGLGACLGPR PRIDE
FLNC_HUMAN_164 19 164 182 LLGWIQNKVPQLPITNFNR PRIDE
FLNC_HUMAN_164 8 164 171 LLGWIQNK PRIDE
FLNC_HUMAN_1657 14 1657 1670 IQIGQETVITVDAK PRIDE
FLNC_HUMAN_1719 32 1719 1750 FGGEHIPNSPFHVLACDPLPHEEEPSEVPQLR PRIDE
FLNC_HUMAN_172 11 172 182 VPQLPITNFNR PRIDE
FLNC_HUMAN_1808 17 1808 1824 TARPNITDNKDGTITVR PRIDE
FLNC_HUMAN_1832 8 1832 1839 GLHQMGIK PRIDE
FLNC_HUMAN_1931 14 1931 1944 FDDKHIPGSPFTAK PRIDE
FLNC_HUMAN_1946 8 1946 1953 ITGDDSMR PRIDE
FLNC_HUMAN_1953 15 1953 1967 TSQLNVGTSTDVSLK PRIDE
FLNC_HUMAN_1968 14 1968 1981 ITESDLSQLTASIR PRIDE
FLNC_HUMAN_1999 9 1999 2007 HIGISFTPK PRIDE
FLNC_HUMAN_2030 13 2030 2042 ILVGPSEIGDASK PRIDE
FLNC_HUMAN_2049 18 2049 2066 GLSEGHTFQVAEFIVDTR PRIDE
FLNC_HUMAN_2097 16 2097 2112 VTYCPTEPGTYIINIK PRIDE
FLNC_HUMAN_2113 14 2113 2126 FADKHVPGSPFTVK PRIDE
FLNC_HUMAN_2159 14 2159 2172 IPGNWFQMVSAQER PRIDE
FLNC_HUMAN_2160 14 2160 2173 IPGNWFQMVSAQER PRIDE
FLNC_HUMAN_2240 21 2240 2260 QQEGEASSQDMTAQVTSPSGK PRIDE
FLNC_HUMAN_2277 14 2277 2290 FVPQEMGPHTVAVK PRIDE
FLNC_HUMAN_2278 14 2278 2291 FVPQEMGPHTVAVK PRIDE
FLNC_HUMAN_2291 25 2291 2315 YRGQHVPGSPFQFTVGPLGEGGAHK PRIDE
FLNC_HUMAN_2326 14 2326 2339 GVAGVPAEFSIWTR PRIDE
FLNC_HUMAN_2340 25 2340 2364 EAGAGGLSIAVEGPSKAEIAFEDRK PRIDE
FLNC_HUMAN_2386 23 2386 2408 FNDEHIPDSPFVVPVASLSDDAR PRIDE
FLNC_HUMAN_2386 24 2386 2409 FNDEHIPDSPFVVPVASLSDDARR PRIDE
FLNC_HUMAN_2443 24 2443 2466 VHTPSGAVEECYVSELDSDKHTIR PRIDE
FLNC_HUMAN_2481 12 2481 2492 FNGAHIPGSPFK PRIDE
FLNC_HUMAN_2576 13 2576 2588 YGGPQHIVGSPFK PRIDE
FLNC_HUMAN_2596 20 2596 2615 LSGGHSLHETSTVLVETVTK PRIDE
FLNC_HUMAN_26 10 26 35 DLAEDAPWKK PRIDE
FLNC_HUMAN_2641 12 2641 2652 GPGLSQAFVGQK PRIDE
FLNC_HUMAN_2663 14 2663 2676 AGTNMMMVGVHGPK PRIDE
FLNC_HUMAN_2676 9 2676 2684 TPCEEVYVK PRIDE
FLNC_HUMAN_2690 9 2690 2698 VYNVTYTVK PRIDE
FLNC_HUMAN_2709 12 2709 2720 WGDESVPGSPFK PRIDE
FLNC_HUMAN_334 9 334 342 TYAVSYVPK PRIDE
FLNC_HUMAN_349 12 349 360 VTVLFAGQNIER PRIDE
FLNC_HUMAN_35 9 35 43 KIQQNTFTR PRIDE
FLNC_HUMAN_437 24 437 460 CTYRPAMEGPHTVHVAFAGAPITR PRIDE
FLNC_HUMAN_502 12 502 513 GAGSGELKVTVK PRIDE
FLNC_HUMAN_544 14 544 557 YVVTITWGGYAIPR PRIDE
FLNC_HUMAN_558 15 558 572 SPFEVQVSPEAGVQK PRIDE
FLNC_HUMAN_575 13 575 587 AWGPGLETGQVGK PRIDE
FLNC_HUMAN_671 24 671 694 AFGPGLEPTGCIVDKPAEFTIDAR PRIDE
FLNC_HUMAN_69 11 69 79 LIALLEVLSQK PRIDE
FLNC_HUMAN_69 12 69 80 LIALLEVLSQKR PRIDE
FLNC_HUMAN_703 14 703 716 LYAQDADGCPIDIK PRIDE
FLNC_HUMAN_737 14 737 750 HTIIISWGGVNVPK PRIDE
FLNC_HUMAN_841 20 841 860 YTIMVLFANQEIPASPFHIK PRIDE
FLNC_HUMAN_879 16 879 894 TGVEVGKPTHFTVLTK PRIDE
FLNC_HUMAN_901 10 901 910 LDVQFAGTAK PRIDE
FLNC_HUMAN_911 20 911 930 GEVVRDFEIIDNHDYSYTVK PRIDE
FLNC_HUMAN_953 15 953 967 SPFVVNVAPPLDLSK PRIDE
FLNC_HUMAN_96 13 96 108 LENVSVALEFLER PRIDE
FLNC_HUMAN_96 17 96 112 LENVSVALEFLEREHIK PRIDE
FLNC_HUMAN_977 14 977 990 VAVGQEQAFSVNTR PRIDE
PAp00003756 14 616 629 IECDDKGDGSCDVR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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