AutismKB 2.0

Annotation Detail for LARP4B


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Basic Information Top
Gene Symbol:LARP4B ( DKFZp686M23113,KIAA0217,LARP5 )
Gene Full Name: La ribonucleoprotein domain family, member 4B
Band: 10p15.3
Quick LinksEntrez ID:23185; OMIM: NA; Uniprot ID:LAR4B_HUMAN; ENSEMBL ID: ENSG00000107929; HGNC ID: 28987
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst4 / 6231964
fetus57 / 564012101
neonate0 / 310970 
infant1 / 2362042
juvenile1 / 5555617
adult129 / 193912166
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma1 / 1747557
breast (mammary gland) tumor3 / 9417831
cervical tumor1 / 3436629
chondrosarcoma16 / 82823193
colorectal tumor10 / 11424687
esophageal tumor0 / 172900 
gastrointestinal tumor9 / 11936975
germ cell tumor9 / 26384534
glioma6 / 10688356
head and neck tumor7 / 13630251
kidney tumor3 / 6895943
leukemia14 / 95842146
liver tumor2 / 9635920
lung tumor3 / 10312729
lymphoma1 / 7175513
non-neoplasia0 / 972500 
normal250 / 336030774
ovarian tumor4 / 7668252
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer2 / 10268019
retinoblastoma3 / 4635664
skin tumor4 / 12494932
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor12 / 90257132
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland2 / 3319760
ascites2 / 4001549
bladder1 / 2975733
blood8 / 12347864
bone8 / 71655111
bone marrow1 / 4880120
brain36 / 110098932
cervix2 / 4817141
connective tissue13 / 14925587
ear0 / 162120 
embryonic tissue9 / 21572241
esophagus1 / 2020949
eye19 / 21105490
heart9 / 89626100
intestine17 / 23447272
kidney8 / 21177737
larynx1 / 2414541
liver8 / 20774338
lung42 / 336974124
lymph0 / 442700 
lymph node60 / 91610654
mammary gland5 / 15327132
mouth3 / 6705244
muscle7 / 10771564
nerve0 / 157680 
ovary4 / 10205139
pancreas5 / 21481223
parathyroid3 / 20539146
pharynx3 / 4132872
pituitary gland0 / 165850 
placenta9 / 28082532
prostate8 / 18934542
salivary gland0 / 201550 
skin9 / 21057442
spleen1 / 5395218
stomach7 / 9661972
testis10 / 33044230
thymus3 / 8113136
thyroid3 / 4747363
tonsil0 / 169990 
trachea3 / 5241357
umbilical cord0 / 136800 
uterus19 / 23287881
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 208952_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts118.75
Adipocyte15.9
AdrenalCortex18.8
Adrenalgland20.05
Amygdala13.05
Appendix15.75
AtrioventricularNode11.85
BDCA4+_DentriticCells54.6
Bonemarrow23.7
BronchialEpithelialCells15.75
CD105+_Endothelial16.6
CD14+_Monocytes44.85
CD19+_BCells(neg._sel.)17.65
CD33+_Myeloid41.9
CD34+21.1
CD4+_Tcells26.7
CD56+_NKCells19.3
CD71+_EarlyErythroid14.9
CD8+_Tcells25.55
CardiacMyocytes19.45
Caudatenucleus12.4
Cerebellum18.85
CerebellumPeduncles17.85
CiliaryGanglion15.9
CingulateCortex14.75
Colorectaladenocarcinoma10.95
DorsalRootGanglion13.85
FetalThyroid14.8
Fetalbrain16.2
Fetalliver13.7
Fetallung20.5
GlobusPallidus10.25
Heart17.2
Hypothalamus16.2
Kidney12.65
Leukemia_chronicMyelogenousK-56221.55
Leukemia_promyelocytic-HL-6024.55
Leukemialymphoblastic(MOLT-4)15.6
Liver18.15
Lung22.75
Lymphnode14.2
Lymphoma_burkitts(Daudi)21.9
Lymphoma_burkitts(Raji)22.8
MedullaOblongata13.75
OccipitalLobe13.8
OlfactoryBulb12.85
Ovary10.4
Pancreas12.55
PancreaticIslet16
ParietalLobe16.55
Pituitary23.8
Placenta77.85
Pons14.95
PrefrontalCortex18.65
Prostate25.1
Salivarygland12.6
SkeletalMuscle23.55
Skin28.1
SmoothMuscle20.5
Spinalcord16.85
SubthalamicNucleus14.35
SuperiorCervicalGanglion22.95
TemporalLobe14.55
Testis32.05
TestisGermCell20.65
TestisIntersitial34.1
TestisLeydigCell31.3
TestisSeminiferousTubule28.9
Thalamus15.6
Thymus17.95
Thyroid19
Tongue15.3
Tonsil24.95
Trachea15.55
TrigeminalGanglion15.35
Uterus12.85
UterusCorpus14.05
WholeBlood17.45
Wholebrain13.45
colon14.85
pineal_day19.72
pineal_night18.6
retina19.225
small_intestine13.55
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_2122_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.82 ± 0.54
Basal Forebrain5.35 ± 0.21
Basal Part of Pons5.92 ± 0.29
Cerebellar Cortex5.77 ± 0.32
Cerebellar Nuclei5.57 ± 0.48
Claustrum5.65 ± 0.57
Epithalamus5.51 ± 0.44
Frontal Lobe5.63 ± 0.39
Globus Pallidus5.56 ± 0.35
Hypothalamus5.38 ± 0.38
Insula5.7 ± 0.3
Limbic Lobe5.7 ± 0.4
Mesencephalon5.57 ± 0.53
Myelencephalon5.59 ± 0.44
Occipital Lobe5.55 ± 0.4
Parietal Lobe5.61 ± 0.41
Pontine Tegmentum5.56 ± 0.43
Striatum5.27 ± 0.41
Subthalamus5.47 ± 0.17
Temporal Lobe5.66 ± 0.42
Thalamus5.62 ± 0.43
White Matter6.04 ± 0.34
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Larp5CBCerebellum53.24
80.49
Larp5CTXCerebral cortex100
100
Larp5HIPHippocampal region74.57
100
Larp5HPFHippocampal formation91.32
100
Larp5HYHypothalamus37.38
34.65
Larp5LSXLateral septal complex38.97
31.57
Larp5MBMidbrain52.07
54.49
Larp5MYMedulla62.46
75.68
Larp5OLFOlfactory bulb78.5
83.05
Larp5PPons48.65
59.6
Larp5PALPallidum63.09
67.37
Larp5RHPRetrohippocampal region100
100
Larp5sAMYStriatum-like amygdalar nuclei95.59
84.51
Larp5STRStriatum87.41
73.29
Larp5STRdStriatum dorsal region97.09
81.55
Larp5STRvStriatum ventral region68.02
56.25
Larp5THThalamus73.36
77.84
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
LAR4B_HUMAN_1 17 1 17 MTSDQDAKVVAEPQTQR PRIDE
PAp00002181 16 583 598 EPSVPASCAVSATYER Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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