AutismKB 2.0

Annotation Detail for ATG4B


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Basic Information Top
Gene Symbol:ATG4B ( APG4B,AUTL1,MGC1353 )
Gene Full Name: ATG4 autophagy related 4 homolog B (S. cerevisiae)
Band: 2q37.3
Quick LinksEntrez ID:23192; OMIM: 611338; Uniprot ID:ATG4B_HUMAN; ENSEMBL ID: ENSG00000168397; HGNC ID: 20790
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body8 / 70761113
blastocyst7 / 62319112
fetus74 / 564012131
neonate2 / 3109764
infant0 / 236200 
juvenile7 / 55556125
adult188 / 193912196
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma1 / 1747557
breast (mammary gland) tumor6 / 9417863
cervical tumor6 / 34366174
chondrosarcoma14 / 82823169
colorectal tumor9 / 11424678
esophageal tumor3 / 17290173
gastrointestinal tumor7 / 11936958
germ cell tumor56 / 263845212
glioma16 / 106883149
head and neck tumor12 / 13630288
kidney tumor10 / 68959145
leukemia16 / 95842166
liver tumor5 / 9635951
lung tumor9 / 10312787
lymphoma10 / 71755139
non-neoplasia6 / 9725061
normal342 / 3360307101
ovarian tumor18 / 76682234
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS37 / 125680294
prostate cancer5 / 10268048
retinoblastoma4 / 4635686
skin tumor16 / 124949128
soft tissue/muscle tissue tumor16 / 125191127
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland4 / 33197120
ascites3 / 4001574
bladder2 / 2975767
blood22 / 123478178
bone6 / 7165583
bone marrow3 / 4880161
brain189 / 1100989171
cervix10 / 48171207
connective tissue11 / 14925573
ear0 / 162120 
embryonic tissue30 / 215722139
esophagus3 / 20209148
eye14 / 21105466
heart6 / 8962666
intestine28 / 234472119
kidney19 / 21177789
larynx0 / 241450 
liver19 / 20774391
lung33 / 33697497
lymph8 / 44270180
lymph node6 / 9161065
mammary gland10 / 15327165
mouth9 / 67052134
muscle14 / 107715129
nerve2 / 15768126
ovary20 / 102051195
pancreas8 / 21481237
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta37 / 280825131
prostate14 / 18934573
salivary gland6 / 20155297
skin25 / 210574118
spleen1 / 5395218
stomach4 / 9661941
testis59 / 330442178
thymus9 / 81131110
thyroid1 / 4747321
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus9 / 23287838
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204903_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts143.6
Adipocyte20.6
AdrenalCortex24.9
Adrenalgland21.5
Amygdala78.15
Appendix16.4
AtrioventricularNode16.3
BDCA4+_DentriticCells262.05
Bonemarrow35.55
BronchialEpithelialCells60.7
CD105+_Endothelial226.7
CD14+_Monocytes118.3
CD19+_BCells(neg._sel.)78.65
CD33+_Myeloid224.65
CD34+166.5
CD4+_Tcells158.05
CD56+_NKCells273.2
CD71+_EarlyErythroid191.95
CD8+_Tcells132.5
CardiacMyocytes30.25
Caudatenucleus20.15
Cerebellum23.8
CerebellumPeduncles25.4
CiliaryGanglion13.35
CingulateCortex17.85
Colorectaladenocarcinoma74.6
DorsalRootGanglion14.9
FetalThyroid19.3
Fetalbrain31.6
Fetalliver18.8
Fetallung31.55
GlobusPallidus14.7
Heart79.15
Hypothalamus35.45
Kidney18.5
Leukemia_chronicMyelogenousK-56265
Leukemia_promyelocytic-HL-6046.65
Leukemialymphoblastic(MOLT-4)64.05
Liver48.85
Lung84.75
Lymphnode32.2
Lymphoma_burkitts(Daudi)48.8
Lymphoma_burkitts(Raji)305.55
MedullaOblongata18.7
OccipitalLobe18.25
OlfactoryBulb21.5
Ovary15.65
Pancreas41.3
PancreaticIslet36.35
ParietalLobe23.8
Pituitary34.3
Placenta29.05
Pons18.6
PrefrontalCortex62
Prostate141.85
Salivarygland8.95
SkeletalMuscle22.45
Skin12.5
SmoothMuscle29.05
Spinalcord38
SubthalamicNucleus19.55
SuperiorCervicalGanglion30.6
TemporalLobe14.55
Testis109.65
TestisGermCell45.9
TestisIntersitial35.4
TestisLeydigCell23.45
TestisSeminiferousTubule50.65
Thalamus20.45
Thymus70.55
Thyroid123.6
Tongue19.3
Tonsil19.25
Trachea22.05
TrigeminalGanglion17.05
Uterus39.65
UterusCorpus18.55
WholeBlood38.85
Wholebrain53.3
colon66.1
pineal_day31.08
pineal_night29.26
retina77.25
small_intestine43.9
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P9903
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6 ± 0.52
Basal Forebrain6.44 ± 0.19
Basal Part of Pons6.63 ± 0.29
Cerebellar Cortex6.46 ± 0.39
Cerebellar Nuclei6.32 ± 0.25
Claustrum5.98 ± 0.66
Epithalamus6.43 ± 0.37
Frontal Lobe6.51 ± 0.37
Globus Pallidus6.02 ± 0.27
Hypothalamus6.52 ± 0.35
Insula6.45 ± 0.27
Limbic Lobe6.18 ± 0.43
Mesencephalon6.21 ± 0.45
Myelencephalon6.26 ± 0.47
Occipital Lobe5.92 ± 0.41
Parietal Lobe6.28 ± 0.37
Pontine Tegmentum6.24 ± 0.42
Striatum5.78 ± 0.36
Subthalamus6.35 ± 0.3
Temporal Lobe6.44 ± 0.36
Thalamus6.3 ± 0.37
White Matter6.59 ± 0.36
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Atg4bCBCerebellum25.2
69.04
Atg4bCTXCerebral cortex77.77
70.16
Atg4bHIPHippocampal region83.67
100
Atg4bHPFHippocampal formation83.72
100
Atg4bHYHypothalamus36.83
33.01
Atg4bLSXLateral septal complex25.17
19.14
Atg4bMBMidbrain48.92
52.3
Atg4bMYMedulla35.31
54.91
Atg4bOLFOlfactory bulb45.09
45.87
Atg4bPPons40.64
55.23
Atg4bPALPallidum26.92
28.05
Atg4bRHPRetrohippocampal region84.99
81.8
Atg4bsAMYStriatum-like amygdalar nuclei36.42
31.22
Atg4bSTRStriatum24.61
19.82
Atg4bSTRdStriatum dorsal region22.23
18.04
Atg4bSTRvStriatum ventral region27.05
20.39
Atg4bTHThalamus75.66
76.18
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
ATG4B_HUMAN_1 12 1 12 MDAATLTYDTLR PRIDE
PAp00011760 17 301 317 TSVPCAGATAFPADSDR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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