AutismKB 2.0

Annotation Detail for PSME4


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Basic Information Top
Gene Symbol:PSME4 ( FLJ21864,KIAA0077,MGC138374,MGC142228,PA200 )
Gene Full Name: proteasome (prosome, macropain) activator subunit 4
Band: 2p16.2
Quick LinksEntrez ID:23198; OMIM: 607705; Uniprot ID:PSME4_HUMAN; ENSEMBL ID: ENSG00000068878; HGNC ID: 20635
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body6 / 7076184
blastocyst3 / 6231948
fetus58 / 564012102
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult144 / 193912174
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma4 / 17475228
breast (mammary gland) tumor6 / 9417863
cervical tumor2 / 3436658
chondrosarcoma10 / 82823120
colorectal tumor17 / 114246148
esophageal tumor1 / 1729057
gastrointestinal tumor9 / 11936975
germ cell tumor17 / 26384564
glioma5 / 10688346
head and neck tumor27 / 136302198
kidney tumor4 / 6895958
leukemia4 / 9584241
liver tumor5 / 9635951
lung tumor1 / 1031279
lymphoma2 / 7175527
non-neoplasia5 / 9725051
normal196 / 336030758
ovarian tumor4 / 7668252
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer5 / 10268048
retinoblastoma2 / 4635643
skin tumor5 / 12494940
soft tissue/muscle tissue tumor8 / 12519163
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites3 / 4001574
bladder5 / 29757168
blood3 / 12347824
bone12 / 71655167
bone marrow1 / 4880120
brain33 / 110098929
cervix2 / 4817141
connective tissue10 / 14925566
ear0 / 162120 
embryonic tissue15 / 21572269
esophagus1 / 2020949
eye13 / 21105461
heart4 / 8962644
intestine26 / 234472110
kidney8 / 21177737
larynx3 / 24145124
liver13 / 20774362
lung6 / 33697417
lymph2 / 4427045
lymph node5 / 9161054
mammary gland11 / 15327171
mouth23 / 67052343
muscle10 / 10771592
nerve1 / 1576863
ovary4 / 10205139
pancreas5 / 21481223
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta8 / 28082528
prostate12 / 18934563
salivary gland0 / 201550 
skin8 / 21057437
spleen0 / 539520 
stomach11 / 96619113
testis38 / 330442114
thymus6 / 8113173
thyroid4 / 4747384
tonsil1 / 1699958
trachea6 / 52413114
umbilical cord0 / 136800 
uterus16 / 23287868
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 212220_at
Cell line Expression level Expression bar
721_B_lymphoblasts24.05
Adipocyte5.7
AdrenalCortex6.35
Adrenalgland5.1
Amygdala5.85
Appendix16.1
AtrioventricularNode5.55
BDCA4+_DentriticCells22.6
Bonemarrow5.95
BronchialEpithelialCells5.85
CD105+_Endothelial13.55
CD14+_Monocytes6.35
CD19+_BCells(neg._sel.)14.9
CD33+_Myeloid7.75
CD34+10.35
CD4+_Tcells10.6
CD56+_NKCells39.85
CD71+_EarlyErythroid32.75
CD8+_Tcells8.5
CardiacMyocytes8.2
Caudatenucleus5.2
Cerebellum4.7
CerebellumPeduncles6.75
CiliaryGanglion4.85
CingulateCortex6.25
Colorectaladenocarcinoma5.9
DorsalRootGanglion5.4
FetalThyroid5.7
Fetalbrain5.8
Fetalliver5.2
Fetallung4.55
GlobusPallidus4.5
Heart8
Hypothalamus6.25
Kidney4.95
Leukemia_chronicMyelogenousK-5625.25
Leukemia_promyelocytic-HL-605.2
Leukemialymphoblastic(MOLT-4)4.55
Liver7.8
Lung6.3
Lymphnode4.95
Lymphoma_burkitts(Daudi)7.5
Lymphoma_burkitts(Raji)8.5
MedullaOblongata5.35
OccipitalLobe5.3
OlfactoryBulb4.7
Ovary4.05
Pancreas4.75
PancreaticIslet6.35
ParietalLobe6.4
Pituitary6.8
Placenta5.8
Pons5.65
PrefrontalCortex7.15
Prostate6.9
Salivarygland4.8
SkeletalMuscle8.45
Skin5.1
SmoothMuscle6.8
Spinalcord6.15
SubthalamicNucleus5.45
SuperiorCervicalGanglion7.75
TemporalLobe5.4
Testis5
TestisGermCell11.9
TestisIntersitial12.7
TestisLeydigCell6.9
TestisSeminiferousTubule5.1
Thalamus5.95
Thymus4.55
Thyroid7.1
Tongue6.1
Tonsil5.8
Trachea4.8
TrigeminalGanglion7.3
Uterus4.8
UterusCorpus5.7
WholeBlood6.3
Wholebrain4.85
colon5.95
pineal_day7.5
pineal_night7.36
retina6.95
small_intestine5.7
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_1184_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.61 ± 0.3
Basal Forebrain7.13 ± 0.31
Basal Part of Pons6.75 ± 0.26
Cerebellar Cortex6.68 ± 0.18
Cerebellar Nuclei7.18 ± 0.44
Claustrum6.77 ± 0.34
Epithalamus7.51 ± 0.23
Frontal Lobe6.88 ± 0.33
Globus Pallidus7.25 ± 0.23
Hypothalamus6.84 ± 0.36
Insula6.62 ± 0.27
Limbic Lobe6.76 ± 0.34
Mesencephalon6.96 ± 0.3
Myelencephalon6.95 ± 0.34
Occipital Lobe7.3 ± 0.42
Parietal Lobe6.93 ± 0.32
Pontine Tegmentum7 ± 0.45
Striatum7.42 ± 0.29
Subthalamus6.67 ± 0.57
Temporal Lobe6.76 ± 0.32
Thalamus7.04 ± 0.24
White Matter8.28 ± 0.07
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Psme4CBCerebellum19.11
19.63
Psme4CTXCerebral cortex74.7
54.58
Psme4HIPHippocampal region38.73
48.2
Psme4HPFHippocampal formation39.96
40.9
Psme4HYHypothalamus12.9
8.98
Psme4LSXLateral septal complex49.52
31.67
Psme4MBMidbrain22.52
19.22
Psme4MYMedulla30.85
32.38
Psme4OLFOlfactory bulb71.05
63.04
Psme4PPons30.11
30.01
Psme4PALPallidum18.98
14.76
Psme4RHPRetrohippocampal region42.39
31.99
Psme4sAMYStriatum-like amygdalar nuclei20.09
14.12
Psme4STRStriatum26
17.08
Psme4STRdStriatum dorsal region22.32
14.78
Psme4STRvStriatum ventral region30.71
19.2
Psme4THThalamus36.68
28.84
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00065293 16 1743 1758 DPGSVGDTIPSAELVK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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