AutismKB 2.0

Annotation Detail for FBXO28


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Basic Information Top
Gene Symbol:FBXO28 ( FLJ10766,Fbx28,KIAA0483 )
Gene Full Name: F-box protein 28
Band: 1q42.11
Quick LinksEntrez ID:23219; OMIM: 609100; Uniprot ID:FBX28_HUMAN; ENSEMBL ID: ENSG00000143756; HGNC ID: 29046
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst3 / 6231948
fetus41 / 56401272
neonate2 / 3109764
infant0 / 236200 
juvenile3 / 5555653
adult96 / 193912149
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma2 / 17475114
breast (mammary gland) tumor5 / 9417853
cervical tumor3 / 3436687
chondrosarcoma0 / 828230 
colorectal tumor8 / 11424670
esophageal tumor1 / 1729057
gastrointestinal tumor6 / 11936950
germ cell tumor23 / 26384587
glioma7 / 10688365
head and neck tumor5 / 13630236
kidney tumor1 / 6895914
leukemia5 / 9584252
liver tumor4 / 9635941
lung tumor5 / 10312748
lymphoma0 / 717550 
non-neoplasia7 / 9725071
normal164 / 336030748
ovarian tumor0 / 766820 
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer6 / 10268058
retinoblastoma1 / 4635621
skin tumor5 / 12494940
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites2 / 4001549
bladder5 / 29757168
blood7 / 12347856
bone3 / 7165541
bone marrow1 / 4880120
brain62 / 110098956
cervix3 / 4817162
connective tissue4 / 14925526
ear1 / 1621261
embryonic tissue10 / 21572246
esophagus1 / 2020949
eye8 / 21105437
heart3 / 8962633
intestine11 / 23447246
kidney19 / 21177789
larynx0 / 241450 
liver10 / 20774348
lung13 / 33697438
lymph0 / 442700 
lymph node3 / 9161032
mammary gland9 / 15327158
mouth5 / 6705274
muscle4 / 10771537
nerve1 / 1576863
ovary2 / 10205119
pancreas1 / 2148124
parathyroid4 / 20539194
pharynx0 / 413280 
pituitary gland2 / 16585120
placenta2 / 2808257
prostate10 / 18934552
salivary gland0 / 201550 
skin11 / 21057452
spleen3 / 5395255
stomach7 / 9661972
testis24 / 33044272
thymus12 / 81131147
thyroid3 / 4747363
tonsil0 / 169990 
trachea3 / 5241357
umbilical cord0 / 136800 
uterus13 / 23287855
vascular4 / 5178077
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202271_at
Cell line Expression level Expression bar
721_B_lymphoblasts9.6
Adipocyte7.95
AdrenalCortex8.25
Adrenalgland6.45
Amygdala14.45
Appendix8.15
AtrioventricularNode6.45
BDCA4+_DentriticCells13.45
Bonemarrow7.2
BronchialEpithelialCells35.6
CD105+_Endothelial30.15
CD14+_Monocytes8.75
CD19+_BCells(neg._sel.)18.45
CD33+_Myeloid9.5
CD34+15.35
CD4+_Tcells19.65
CD56+_NKCells10.3
CD71+_EarlyErythroid5.85
CD8+_Tcells10.95
CardiacMyocytes9.35
Caudatenucleus8.15
Cerebellum6.45
CerebellumPeduncles8.45
CiliaryGanglion6.1
CingulateCortex8.4
Colorectaladenocarcinoma7.6
DorsalRootGanglion6.15
FetalThyroid8
Fetalbrain9.1
Fetalliver6.8
Fetallung8.6
GlobusPallidus5.9
Heart9.25
Hypothalamus14.1
Kidney6.5
Leukemia_chronicMyelogenousK-5626.7
Leukemia_promyelocytic-HL-606.6
Leukemialymphoblastic(MOLT-4)6.05
Liver10.05
Lung7.45
Lymphnode6.95
Lymphoma_burkitts(Daudi)9.7
Lymphoma_burkitts(Raji)10.45
MedullaOblongata8.4
OccipitalLobe15.55
OlfactoryBulb6.75
Ovary5.3
Pancreas5.8
PancreaticIslet8.6
ParietalLobe8.2
Pituitary9.85
Placenta8.05
Pons8.1
PrefrontalCortex13.6
Prostate16.6
Salivarygland7.9
SkeletalMuscle8.9
Skin7.8
SmoothMuscle10.3
Spinalcord9.4
SubthalamicNucleus6.95
SuperiorCervicalGanglion10.05
TemporalLobe6.9
Testis6.4
TestisGermCell7.7
TestisIntersitial6.1
TestisLeydigCell7.4
TestisSeminiferousTubule6.5
Thalamus8.1
Thymus5.8
Thyroid14.65
Tongue7.9
Tonsil8.1
Trachea14.4
TrigeminalGanglion10.2
Uterus11.1
UterusCorpus7
WholeBlood14.5
Wholebrain17.7
colon9
pineal_day42.16
pineal_night46.9
retina16.725
small_intestine7.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P137578
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.73 ± 0.5
Basal Forebrain6.84 ± 0.21
Basal Part of Pons7.33 ± 0.34
Cerebellar Cortex7.05 ± 0.28
Cerebellar Nuclei7.09 ± 0.46
Claustrum6.72 ± 0.53
Epithalamus7.07 ± 0.19
Frontal Lobe6.97 ± 0.32
Globus Pallidus6.08 ± 0.26
Hypothalamus6.95 ± 0.43
Insula6.84 ± 0.29
Limbic Lobe6.93 ± 0.43
Mesencephalon6.92 ± 0.39
Myelencephalon6.91 ± 0.42
Occipital Lobe7.35 ± 0.3
Parietal Lobe7.07 ± 0.34
Pontine Tegmentum6.88 ± 0.3
Striatum6.8 ± 0.28
Subthalamus7.21 ± 0.24
Temporal Lobe7.01 ± 0.36
Thalamus6.95 ± 0.29
White Matter6.59 ± 0.31
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Fbxo28CBCerebellum24.58
30.08
Fbxo28CTXCerebral cortex79.36
67.23
Fbxo28HIPHippocampal region46.84
66.77
Fbxo28HPFHippocampal formation52.19
60.57
Fbxo28HYHypothalamus32.13
25.01
Fbxo28LSXLateral septal complex53.84
40.86
Fbxo28MBMidbrain37.74
35.5
Fbxo28MYMedulla50.87
58.99
Fbxo28OLFOlfactory bulb63.86
58.22
Fbxo28PPons39.96
43.49
Fbxo28PALPallidum33.53
33.3
Fbxo28RHPRetrohippocampal region62.68
53.02
Fbxo28sAMYStriatum-like amygdalar nuclei46.03
36.77
Fbxo28STRStriatum42.26
31.13
Fbxo28STRdStriatum dorsal region40.98
30.11
Fbxo28STRvStriatum ventral region39.87
27.4
Fbxo28THThalamus45.66
39.8
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00510295 23 9 31 MAEEGGGGQGDGGSSLASGSTQR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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