AutismKB 2.0

Annotation Detail for EXOC6B


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Basic Information Top
Gene Symbol:EXOC6B ( KIAA0919,SEC15B,SEC15L2 )
Gene Full Name: exocyst complex component 6B
Band: 2p13.2
Quick LinksEntrez ID:23233; OMIM: 607880; Uniprot ID:EXC6B_HUMAN; ENSEMBL ID: ENSG00000144036; HGNC ID: 17085
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst5 / 6231980
fetus22 / 56401239
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult76 / 193912139
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma4 / 8282348
colorectal tumor0 / 1142460 
esophageal tumor1 / 1729057
gastrointestinal tumor3 / 11936925
germ cell tumor11 / 26384541
glioma1 / 1068839
head and neck tumor6 / 13630244
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal136 / 336030740
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer0 / 1026800 
retinoblastoma1 / 4635621
skin tumor2 / 12494916
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites2 / 4001549
bladder1 / 2975733
blood0 / 1234780 
bone2 / 7165527
bone marrow0 / 488010 
brain48 / 110098943
cervix0 / 481710 
connective tissue5 / 14925533
ear0 / 162120 
embryonic tissue8 / 21572237
esophagus1 / 2020949
eye3 / 21105414
heart4 / 8962644
intestine1 / 2344724
kidney2 / 2117779
larynx2 / 2414582
liver0 / 2077430 
lung1 / 3369742
lymph0 / 442700 
lymph node0 / 916100 
mammary gland2 / 15327113
mouth1 / 6705214
muscle6 / 10771555
nerve1 / 1576863
ovary0 / 1020510 
pancreas3 / 21481213
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland1 / 1658560
placenta36 / 280825128
prostate0 / 1893450 
salivary gland1 / 2015549
skin4 / 21057418
spleen2 / 5395237
stomach1 / 9661910
testis16 / 33044248
thymus0 / 811310 
thyroid2 / 4747342
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus6 / 23287825
vascular2 / 5178038
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_886_PI416573500
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.2 ± 0.36
Basal Forebrain7.36 ± 0.12
Basal Part of Pons7.31 ± 0.32
Cerebellar Cortex6.99 ± 0.23
Cerebellar Nuclei7.57 ± 0.26
Claustrum7.31 ± 0.52
Epithalamus6.76 ± 0.61
Frontal Lobe7.21 ± 0.38
Globus Pallidus7.64 ± 0.22
Hypothalamus7.16 ± 0.35
Insula6.99 ± 0.16
Limbic Lobe7.38 ± 0.36
Mesencephalon7.41 ± 0.37
Myelencephalon7.26 ± 0.34
Occipital Lobe7.42 ± 0.33
Parietal Lobe7.28 ± 0.32
Pontine Tegmentum7.32 ± 0.34
Striatum7.65 ± 0.28
Subthalamus7.74 ± 0.22
Temporal Lobe7.16 ± 0.29
Thalamus7.25 ± 0.26
White Matter8.09 ± 0.13
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Sec15l2CBCerebellum24.26
55.23
Sec15l2CTXCerebral cortex34.17
27.31
Sec15l2HIPHippocampal region42.86
70.39
Sec15l2HPFHippocampal formation40.81
54.58
Sec15l2HYHypothalamus12.07
10.05
Sec15l2LSXLateral septal complex10.4
7.76
Sec15l2MBMidbrain18.46
17.97
Sec15l2MYMedulla27.59
33.24
Sec15l2OLFOlfactory bulb20.2
15.82
Sec15l2PPons19.34
21.35
Sec15l2PALPallidum16.34
15.63
Sec15l2RHPRetrohippocampal region38.2
34.29
Sec15l2sAMYStriatum-like amygdalar nuclei9.57
7.59
Sec15l2STRStriatum9.93
7.69
Sec15l2STRdStriatum dorsal region10.09
8.12
Sec15l2STRvStriatum ventral region9.4
6.37
Sec15l2THThalamus14.08
12.73
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00043335 21 572 592 YLEEFITNITNVLPETVHTTK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018