AutismKB 2.0

Annotation Detail for PHLPP1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:PHLPP1 ( MGC161555,PHLPP,PLEKHE1,SCOP )
Gene Full Name: PH domain and leucine rich repeat protein phosphatase 1
Band: 18q21.33
Quick LinksEntrez ID:23239; OMIM: 609396; Uniprot ID:PHLP1_HUMAN; ENSEMBL ID: ENSG00000081913; HGNC ID: 20610
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst4 / 6231964
fetus32 / 56401256
neonate0 / 310970 
infant2 / 2362084
juvenile1 / 5555617
adult49 / 193912125
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor7 / 26384526
glioma3 / 10688328
head and neck tumor4 / 13630229
kidney tumor0 / 689590 
leukemia6 / 9584262
liver tumor1 / 9635910
lung tumor0 / 1031270 
lymphoma1 / 7175513
non-neoplasia1 / 9725010
normal128 / 336030738
ovarian tumor1 / 7668213
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer4 / 10268038
retinoblastoma5 / 46356107
skin tumor8 / 12494964
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood4 / 12347832
bone3 / 7165541
bone marrow2 / 4880140
brain51 / 110098946
cervix1 / 4817120
connective tissue0 / 1492550 
ear1 / 1621261
embryonic tissue7 / 21572232
esophagus0 / 202090 
eye19 / 21105490
heart0 / 896260 
intestine2 / 2344728
kidney2 / 2117779
larynx0 / 241450 
liver3 / 20774314
lung6 / 33697417
lymph1 / 4427022
lymph node5 / 9161054
mammary gland1 / 1532716
mouth4 / 6705259
muscle3 / 10771527
nerve1 / 1576863
ovary1 / 1020519
pancreas1 / 2148124
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta7 / 28082524
prostate5 / 18934526
salivary gland0 / 201550 
skin9 / 21057442
spleen1 / 5395218
stomach0 / 966190 
testis10 / 33044230
thymus0 / 811310 
thyroid1 / 4747321
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus4 / 23287817
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 212719_at
Cell line Expression level Expression bar
721_B_lymphoblasts95.25
Adipocyte10.85
AdrenalCortex23.9
Adrenalgland15.7
Amygdala133.95
Appendix11.6
AtrioventricularNode11.2
BDCA4+_DentriticCells10.75
Bonemarrow9.25
BronchialEpithelialCells10.4
CD105+_Endothelial12.15
CD14+_Monocytes9.1
CD19+_BCells(neg._sel.)12.2
CD33+_Myeloid11.3
CD34+20.65
CD4+_Tcells8.55
CD56+_NKCells9.3
CD71+_EarlyErythroid7.7
CD8+_Tcells6.75
CardiacMyocytes12.3
Caudatenucleus85.35
Cerebellum31.3
CerebellumPeduncles28.25
CiliaryGanglion8.25
CingulateCortex40.25
Colorectaladenocarcinoma9.15
DorsalRootGanglion10.05
FetalThyroid17.35
Fetalbrain15.05
Fetalliver9.7
Fetallung10.55
GlobusPallidus14.75
Heart15.85
Hypothalamus89.3
Kidney10.35
Leukemia_chronicMyelogenousK-5629.2
Leukemia_promyelocytic-HL-6016.3
Leukemialymphoblastic(MOLT-4)8.9
Liver24.15
Lung12.45
Lymphnode7.5
Lymphoma_burkitts(Daudi)12.55
Lymphoma_burkitts(Raji)29.45
MedullaOblongata59.3
OccipitalLobe69.8
OlfactoryBulb15.25
Ovary7.95
Pancreas9.6
PancreaticIslet12.35
ParietalLobe84.4
Pituitary15.15
Placenta37.3
Pons21.9
PrefrontalCortex313.75
Prostate18.05
Salivarygland11.7
SkeletalMuscle20.5
Skin10.9
SmoothMuscle12.75
Spinalcord43.65
SubthalamicNucleus13.7
SuperiorCervicalGanglion14.4
TemporalLobe13.4
Testis13.55
TestisGermCell12.45
TestisIntersitial16.95
TestisLeydigCell13.85
TestisSeminiferousTubule13.9
Thalamus65.1
Thymus8.4
Thyroid17.9
Tongue14.4
Tonsil9.45
Trachea9.4
TrigeminalGanglion12.85
Uterus11.25
UterusCorpus13.05
WholeBlood15.5
Wholebrain105.2
colon14.4
pineal_day944.02
pineal_night945.56
retina92.1
small_intestine13.2
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_12224_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.19 ± 0.97
Basal Forebrain2.95 ± 0.47
Basal Part of Pons2.48 ± 0.74
Cerebellar Cortex2.61 ± 0.68
Cerebellar Nuclei3.08 ± 0.8
Claustrum3.52 ± 1.07
Epithalamus2.88 ± 0.69
Frontal Lobe2.65 ± 0.77
Globus Pallidus4 ± 0.49
Hypothalamus2.88 ± 0.92
Insula2.78 ± 0.85
Limbic Lobe2.85 ± 0.93
Mesencephalon3.14 ± 0.85
Myelencephalon2.92 ± 0.8
Occipital Lobe3.42 ± 0.71
Parietal Lobe2.88 ± 0.87
Pontine Tegmentum3.02 ± 0.96
Striatum3.44 ± 0.81
Subthalamus3.09 ± 1.18
Temporal Lobe2.79 ± 0.81
Thalamus2.95 ± 0.66
White Matter4.97 ± 0.29
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
PhlppCBCerebellum31.76
37.49
PhlppCTXCerebral cortex35.8
25.83
PhlppHIPHippocampal region34.97
35.74
PhlppHPFHippocampal formation34.94
31.26
PhlppHYHypothalamus29.12
20.54
PhlppLSXLateral septal complex38.01
26.9
PhlppMBMidbrain42.6
32.75
PhlppMYMedulla43.93
34.99
PhlppOLFOlfactory bulb28.84
21.15
PhlppPPons41.17
31.44
PhlppPALPallidum34.33
26.17
PhlppRHPRetrohippocampal region34.07
24.81
PhlppsAMYStriatum-like amygdalar nuclei12.1
7.8
PhlppSTRStriatum25.8
18.37
PhlppSTRdStriatum dorsal region27.37
20.25
PhlppSTRvStriatum ventral region23.33
15.02
PhlppTHThalamus55.26
45.9
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00026212 18 918 935 KLEVLDIGHNQICELPAR Peptide Atlas
PHLP1_HUMAN_1 11 1 11 MEPAAAATVQR PRIDE
PHLP1_HUMAN_27 23 27 49 AAAAAAAAAAAAAALAAAAGGGR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved