AutismKB 2.0

Annotation Detail for COBL


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Basic Information Top
Gene Symbol:COBL ( DKFZp686G13227,KIAA0633,MGC131893 )
Gene Full Name: cordon-bleu homolog (mouse)
Band: 7p12.1
Quick LinksEntrez ID:23242; OMIM: 610317; Uniprot ID:COBL_HUMAN; ENSEMBL ID: ENSG00000106078; HGNC ID: 22199
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst1 / 6231916
fetus14 / 56401224
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult69 / 193912135
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor8 / 34366232
chondrosarcoma0 / 828230 
colorectal tumor4 / 11424635
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor4 / 26384515
glioma5 / 10688346
head and neck tumor1 / 1363027
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor1 / 9635910
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia6 / 9725061
normal106 / 336030731
ovarian tumor0 / 766820 
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer6 / 10268058
retinoblastoma1 / 4635621
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder1 / 2975733
blood0 / 1234780 
bone1 / 7165513
bone marrow0 / 488010 
brain54 / 110098949
cervix12 / 48171249
connective tissue0 / 1492550 
ear1 / 1621261
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye6 / 21105428
heart2 / 8962622
intestine4 / 23447217
kidney1 / 2117774
larynx0 / 241450 
liver4 / 20774319
lung6 / 33697417
lymph0 / 442700 
lymph node1 / 9161010
mammary gland5 / 15327132
mouth4 / 6705259
muscle3 / 10771527
nerve0 / 157680 
ovary1 / 1020519
pancreas12 / 21481255
parathyroid3 / 20539146
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta4 / 28082514
prostate7 / 18934536
salivary gland1 / 2015549
skin1 / 2105744
spleen0 / 539520 
stomach0 / 966190 
testis2 / 3304426
thymus0 / 811310 
thyroid1 / 4747321
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus7 / 23287830
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 213050_at
Cell line Expression level Expression bar
721_B_lymphoblasts4.2
Adipocyte3.4
AdrenalCortex3.5
Adrenalgland2.9
Amygdala163.85
Appendix3.45
AtrioventricularNode2.6
BDCA4+_DentriticCells3.9
Bonemarrow3.4
BronchialEpithelialCells3.45
CD105+_Endothelial3.35
CD14+_Monocytes3.55
CD19+_BCells(neg._sel.)3.6
CD33+_Myeloid4.3
CD34+4.3
CD4+_Tcells3.65
CD56+_NKCells3.95
CD71+_EarlyErythroid3.15
CD8+_Tcells3.25
CardiacMyocytes4.25
Caudatenucleus72.65
Cerebellum12.5
CerebellumPeduncles18.65
CiliaryGanglion2.4
CingulateCortex87.95
Colorectaladenocarcinoma18.8
DorsalRootGanglion2.6
FetalThyroid3.4
Fetalbrain6.7
Fetalliver3
Fetallung3.05
GlobusPallidus6.05
Heart4.35
Hypothalamus138.2
Kidney5.2
Leukemia_chronicMyelogenousK-5623.15
Leukemia_promyelocytic-HL-603.05
Leukemialymphoblastic(MOLT-4)2.75
Liver7.05
Lung13.95
Lymphnode3
Lymphoma_burkitts(Daudi)4.4
Lymphoma_burkitts(Raji)4.8
MedullaOblongata92.95
OccipitalLobe68.1
OlfactoryBulb7.4
Ovary2.25
Pancreas4.4
PancreaticIslet4.35
ParietalLobe43.2
Pituitary4
Placenta3.65
Pons5.35
PrefrontalCortex302
Prostate16.45
Salivarygland3.9
SkeletalMuscle3.85
Skin3.5
SmoothMuscle3.8
Spinalcord48.7
SubthalamicNucleus38.05
SuperiorCervicalGanglion3.85
TemporalLobe9.95
Testis3
TestisGermCell2.9
TestisIntersitial2.9
TestisLeydigCell3.45
TestisSeminiferousTubule3
Thalamus75.05
Thymus2.65
Thyroid11.25
Tongue3.35
Tonsil3.35
Trachea6.6
TrigeminalGanglion3.45
Uterus2.85
UterusCorpus3.05
WholeBlood3.65
Wholebrain209.1
colon3.5
pineal_day4.84
pineal_night7.22
retina12.25
small_intestine3.45
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P86173
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.37 ± 0.51
Basal Forebrain7.12 ± 0.37
Basal Part of Pons6.97 ± 0.31
Cerebellar Cortex6.45 ± 0.25
Cerebellar Nuclei7.02 ± 0.37
Claustrum7.68 ± 0.24
Epithalamus7.26 ± 0.24
Frontal Lobe6.83 ± 0.48
Globus Pallidus7.48 ± 0.21
Hypothalamus6.15 ± 0.45
Insula6.8 ± 0.27
Limbic Lobe6.89 ± 0.55
Mesencephalon6.96 ± 0.48
Myelencephalon6.99 ± 0.52
Occipital Lobe7.02 ± 0.37
Parietal Lobe7 ± 0.48
Pontine Tegmentum6.89 ± 0.56
Striatum7.12 ± 0.43
Subthalamus6.82 ± 0.25
Temporal Lobe6.95 ± 0.4
Thalamus6.96 ± 0.35
White Matter8.45 ± 0.49
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
CoblCBCerebellum11.19
14.08
CoblCTXCerebral cortex94.76
90.45
CoblHIPHippocampal region7.91
7.17
CoblHPFHippocampal formation26.43
24.87
CoblHYHypothalamus8.3
6.11
CoblLSXLateral septal complex2.39
2.36
CoblMBMidbrain12.24
10.83
CoblMYMedulla17.18
18.74
CoblOLFOlfactory bulb34.3
32.58
CoblPPons11.83
11.98
CoblPALPallidum7.99
10.32
CoblRHPRetrohippocampal region59.09
51.01
CoblsAMYStriatum-like amygdalar nuclei19.86
15.48
CoblSTRStriatum30.97
23.68
CoblSTRdStriatum dorsal region38.27
29.75
CoblSTRvStriatum ventral region22.35
15.62
CoblTHThalamus11.77
10.06
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
COBL_HUMAN_1106 18 1106 1123 DTSLHSALMEAIHSAGGK PRIDE
COBL_HUMAN_1129 12 1129 1140 TAEHTGEGRPAK PRIDE
COBL_HUMAN_157 7 157 163 LVVNYLR PRIDE
COBL_HUMAN_212 8 212 219 SLNELGIK PRIDE
COBL_HUMAN_561 15 561 575 NNNAGSFDSEGVASR PRIDE
COBL_HUMAN_6 10 6 15 ASAAKPPTGR PRIDE
COBL_HUMAN_666 9 666 674 VNSQPVNEK PRIDE
COBL_HUMAN_680 12 680 691 NAALAPTSWHQR PRIDE
COBL_HUMAN_703 7 703 709 HGLTTYK PRIDE
COBL_HUMAN_749 18 749 766 IISLSSSVPEAESQPIGK PRIDE
COBL_HUMAN_77 32 77 108 SVLNGSHAMMDLLVELCLQNHLNPSHHALEIR PRIDE
COBL_HUMAN_846 16 846 861 VPAAHTTEVTFLKPQR PRIDE
COBL_HUMAN_863 12 863 874 TSSQYVASAIAK PRIDE
COBL_HUMAN_915 12 915 926 TSSPHSETQGWK PRIDE
COBL_HUMAN_985 14 985 998 DRVSVGQSCGFSGK PRIDE
PAp00009759 14 719 732 CYDRDVSLSTGAIK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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