AutismKB 2.0

Annotation Detail for PDS5A


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Basic Information Top
Gene Symbol:PDS5A ( DKFZp686B19246,FLJ41012,KIAA0648,MGC131948,MGC161503,SCC-112 )
Gene Full Name: PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)
Band: 4p14
Quick LinksEntrez ID:23244; OMIM: 613200; Uniprot ID:PDS5A_HUMAN; ENSEMBL ID: ENSG00000121892; HGNC ID: 29088
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst6 / 6231996
fetus58 / 564012102
neonate0 / 310970 
infant2 / 2362084
juvenile6 / 55556107
adult157 / 193912180
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor7 / 9417874
cervical tumor3 / 3436687
chondrosarcoma16 / 82823193
colorectal tumor12 / 114246105
esophageal tumor0 / 172900 
gastrointestinal tumor12 / 119369100
germ cell tumor24 / 26384590
glioma4 / 10688337
head and neck tumor14 / 136302102
kidney tumor7 / 68959101
leukemia10 / 95842104
liver tumor6 / 9635962
lung tumor3 / 10312729
lymphoma5 / 7175569
non-neoplasia2 / 9725020
normal236 / 336030770
ovarian tumor4 / 7668252
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer16 / 102680155
retinoblastoma13 / 46356280
skin tumor8 / 12494964
soft tissue/muscle tissue tumor16 / 125191127
uterine tumor12 / 90257132
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites3 / 4001574
bladder2 / 2975767
blood7 / 12347856
bone13 / 71655181
bone marrow9 / 48801184
brain54 / 110098949
cervix3 / 4817162
connective tissue13 / 14925587
ear3 / 16212185
embryonic tissue20 / 21572292
esophagus0 / 202090 
eye21 / 21105499
heart6 / 8962666
intestine26 / 234472110
kidney18 / 21177784
larynx1 / 2414541
liver15 / 20774372
lung13 / 33697438
lymph3 / 4427067
lymph node16 / 91610174
mammary gland11 / 15327171
mouth9 / 67052134
muscle8 / 10771574
nerve1 / 1576863
ovary5 / 10205148
pancreas12 / 21481255
parathyroid1 / 2053948
pharynx2 / 4132848
pituitary gland2 / 16585120
placenta26 / 28082592
prostate19 / 189345100
salivary gland2 / 2015599
skin17 / 21057480
spleen1 / 5395218
stomach7 / 9661972
testis27 / 33044281
thymus6 / 8113173
thyroid3 / 4747363
tonsil2 / 16999117
trachea4 / 5241376
umbilical cord0 / 136800 
uterus31 / 232878133
vascular5 / 5178096
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 212138_at
Cell line Expression level Expression bar
721_B_lymphoblasts137.25
Adipocyte8.15
AdrenalCortex9.5
Adrenalgland7
Amygdala8.4
Appendix9.85
AtrioventricularNode6.8
BDCA4+_DentriticCells84.55
Bonemarrow8.4
BronchialEpithelialCells18.15
CD105+_Endothelial168.1
CD14+_Monocytes17.15
CD19+_BCells(neg._sel.)47.4
CD33+_Myeloid86.85
CD34+173.8
CD4+_Tcells80.45
CD56+_NKCells104.2
CD71+_EarlyErythroid52.75
CD8+_Tcells41.6
CardiacMyocytes11.35
Caudatenucleus7.2
Cerebellum6.65
CerebellumPeduncles9.4
CiliaryGanglion6.1
CingulateCortex8.45
Colorectaladenocarcinoma10.45
DorsalRootGanglion6.6
FetalThyroid8.15
Fetalbrain9.8
Fetalliver7.6
Fetallung8.55
GlobusPallidus6.15
Heart11
Hypothalamus8.7
Kidney6.7
Leukemia_chronicMyelogenousK-56213.2
Leukemia_promyelocytic-HL-6023.15
Leukemialymphoblastic(MOLT-4)42.5
Liver10.95
Lung8.65
Lymphnode9.45
Lymphoma_burkitts(Daudi)34.7
Lymphoma_burkitts(Raji)14.6
MedullaOblongata7.4
OccipitalLobe7.35
OlfactoryBulb6.85
Ovary6.15
Pancreas6.65
PancreaticIslet8.95
ParietalLobe8.7
Pituitary9.65
Placenta8.05
Pons7.9
PrefrontalCortex10
Prostate10
Salivarygland8.7
SkeletalMuscle10.3
Skin7.3
SmoothMuscle10.4
Spinalcord8.55
SubthalamicNucleus7.55
SuperiorCervicalGanglion10.05
TemporalLobe7.75
Testis6.75
TestisGermCell6.55
TestisIntersitial6.75
TestisLeydigCell8.2
TestisSeminiferousTubule6.9
Thalamus8.45
Thymus6.5
Thyroid15.45
Tongue8.65
Tonsil13.35
Trachea8.35
TrigeminalGanglion9.05
Uterus14.65
UterusCorpus7.6
WholeBlood18.8
Wholebrain6.4
colon27.9
pineal_day14.1
pineal_night13.52
retina9.925
small_intestine12.55
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P144294
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.86 ± 0.41
Basal Forebrain7.08 ± 0.25
Basal Part of Pons7.26 ± 0.13
Cerebellar Cortex7.38 ± 0.18
Cerebellar Nuclei7.49 ± 0.17
Claustrum7.07 ± 0.59
Epithalamus7.48 ± 0.35
Frontal Lobe7.23 ± 0.28
Globus Pallidus7.48 ± 0.3
Hypothalamus7.2 ± 0.34
Insula7.23 ± 0.32
Limbic Lobe7.06 ± 0.33
Mesencephalon7.16 ± 0.4
Myelencephalon7.16 ± 0.32
Occipital Lobe7.33 ± 0.32
Parietal Lobe7.26 ± 0.35
Pontine Tegmentum7.27 ± 0.32
Striatum7.06 ± 0.35
Subthalamus7.51 ± 0.17
Temporal Lobe7.18 ± 0.27
Thalamus7.3 ± 0.24
White Matter7.99 ± 0.2
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
9030416H16RikCBCerebellum4.58
4.92
9030416H16RikCTXCerebral cortex5.55
3.79
9030416H16RikHIPHippocampal region11.41
10.8
9030416H16RikHPFHippocampal formation7.2
6.36
9030416H16RikHYHypothalamus0.27
0.21
9030416H16RikLSXLateral septal complex0.39
0.25
9030416H16RikMBMidbrain0.84
1.03
9030416H16RikMYMedulla1.35
1.35
9030416H16RikOLFOlfactory bulb2.68
2.08
9030416H16RikPPons1.45
1.61
9030416H16RikPALPallidum0.58
0.41
9030416H16RikRHPRetrohippocampal region0.68
0.6
9030416H16RiksAMYStriatum-like amygdalar nuclei0.06
0.04
9030416H16RikSTRStriatum0.58
0.35
9030416H16RikSTRdStriatum dorsal region0.65
0.38
9030416H16RikSTRvStriatum ventral region0.64
0.39
9030416H16RikTHThalamus4.5
3.23
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00002326 21 346 366 FASHCLMNHPDLAKDLTEYLK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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