AutismKB 2.0

Annotation Detail for ASTN2


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Basic Information Top
Gene Symbol:ASTN2 ( KIAA0634,bA67K19.1 )
Gene Full Name: astrotactin 2
Band: 9q33.1
Quick LinksEntrez ID:23245; OMIM: 612856; Uniprot ID:ASTN2_HUMAN; ENSEMBL ID: ENSG00000148219; HGNC ID: 17021
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst2 / 6231932
fetus8 / 56401214
neonate0 / 310970 
infant1 / 2362042
juvenile1 / 5555617
adult49 / 193912125
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor2 / 3436658
chondrosarcoma2 / 8282324
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor12 / 26384545
glioma8 / 10688374
head and neck tumor1 / 1363027
kidney tumor3 / 6895943
leukemia0 / 958420 
liver tumor2 / 9635920
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal92 / 336030727
ovarian tumor4 / 7668252
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS8 / 12568063
prostate cancer0 / 1026800 
retinoblastoma3 / 4635664
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland2 / 3319760
ascites2 / 4001549
bladder0 / 297570 
blood1 / 1234788
bone2 / 7165527
bone marrow0 / 488010 
brain48 / 110098943
cervix2 / 4817141
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus0 / 202090 
eye13 / 21105461
heart1 / 8962611
intestine1 / 2344724
kidney5 / 21177723
larynx0 / 241450 
liver2 / 2077439
lung3 / 3369748
lymph0 / 442700 
lymph node0 / 916100 
mammary gland1 / 1532716
mouth1 / 6705214
muscle2 / 10771518
nerve0 / 157680 
ovary4 / 10205139
pancreas1 / 2148124
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland2 / 16585120
placenta3 / 28082510
prostate8 / 18934542
salivary gland0 / 201550 
skin0 / 2105740 
spleen2 / 5395237
stomach1 / 9661910
testis21 / 33044263
thymus1 / 8113112
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus6 / 23287825
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 215407_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.95
Adipocyte6.6
AdrenalCortex8.05
Adrenalgland6.05
Amygdala8.75
Appendix7.9
AtrioventricularNode5.85
BDCA4+_DentriticCells6.45
Bonemarrow7.35
BronchialEpithelialCells6.8
CD105+_Endothelial6.8
CD14+_Monocytes7.25
CD19+_BCells(neg._sel.)6.95
CD33+_Myeloid8.15
CD34+8.7
CD4+_Tcells7.25
CD56+_NKCells7.75
CD71+_EarlyErythroid6.65
CD8+_Tcells6.25
CardiacMyocytes10.2
Caudatenucleus6.4
Cerebellum13
CerebellumPeduncles19.5
CiliaryGanglion5.5
CingulateCortex7.3
Colorectaladenocarcinoma6.95
DorsalRootGanglion5.75
FetalThyroid6.65
Fetalbrain6.7
Fetalliver6.05
Fetallung5.3
GlobusPallidus5.35
Heart10
Hypothalamus10.65
Kidney6.05
Leukemia_chronicMyelogenousK-5626.1
Leukemia_promyelocytic-HL-606
Leukemialymphoblastic(MOLT-4)5.35
Liver9.6
Lung7.6
Lymphnode5.75
Lymphoma_burkitts(Daudi)9
Lymphoma_burkitts(Raji)10.3
MedullaOblongata7.15
OccipitalLobe7.45
OlfactoryBulb6
Ovary4.9
Pancreas5.65
PancreaticIslet7.3
ParietalLobe8.3
Pituitary9.9
Placenta6.95
Pons6.8
PrefrontalCortex12.55
Prostate29.75
Salivarygland5.7
SkeletalMuscle9.4
Skin5.8
SmoothMuscle7.7
Spinalcord7.9
SubthalamicNucleus7.45
SuperiorCervicalGanglion11.2
TemporalLobe6.55
Testis14.2
TestisGermCell14.6
TestisIntersitial10.6
TestisLeydigCell9.45
TestisSeminiferousTubule6.15
Thalamus13.1
Thymus5.6
Thyroid8.1
Tongue7.25
Tonsil6.85
Trachea5.7
TrigeminalGanglion7.9
Uterus5.55
UterusCorpus8.1
WholeBlood7.4
Wholebrain10.35
colon6.75
pineal_day98.9
pineal_night44.12
retina9.95
small_intestine6.5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P83738
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.76 ± 0.48
Basal Forebrain6.42 ± 0.54
Basal Part of Pons7 ± 0.36
Cerebellar Cortex6.47 ± 0.45
Cerebellar Nuclei6.77 ± 0.34
Claustrum7.15 ± 0.58
Epithalamus6.57 ± 0.3
Frontal Lobe6.64 ± 0.54
Globus Pallidus6.79 ± 0.41
Hypothalamus6.41 ± 0.56
Insula6.63 ± 0.58
Limbic Lobe6.78 ± 0.55
Mesencephalon6.59 ± 0.58
Myelencephalon6.67 ± 0.53
Occipital Lobe6.83 ± 0.41
Parietal Lobe6.75 ± 0.51
Pontine Tegmentum6.59 ± 0.41
Striatum6.77 ± 0.6
Subthalamus6.98 ± 0.42
Temporal Lobe6.62 ± 0.54
Thalamus6.76 ± 0.33
White Matter6.88 ± 0.27
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Astn2CBCerebellum100
100
Astn2CTXCerebral cortex100
100
Astn2HIPHippocampal region33.77
50.33
Astn2HPFHippocampal formation62.06
81.51
Astn2HYHypothalamus89.86
85.36
Astn2LSXLateral septal complex100
100
Astn2MBMidbrain77.5
76
Astn2MYMedulla83.12
94.4
Astn2OLFOlfactory bulb93.61
93.77
Astn2PPons60.7
61.99
Astn2PALPallidum68.72
66.17
Astn2RHPRetrohippocampal region98.92
100
Astn2sAMYStriatum-like amygdalar nuclei78.81
67.9
Astn2STRStriatum54.46
47.61
Astn2STRdStriatum dorsal region47.57
43.09
Astn2STRvStriatum ventral region38.36
30.42
Astn2THThalamus95.75
96.51
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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