AutismKB 2.0

Annotation Detail for WWC1


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Basic Information Top
Gene Symbol:WWC1 ( FLJ10865,FLJ23369,HBEBP3,HBEBP36,KIAA0869,KIBRA )
Gene Full Name: WW and C2 domain containing 1
Band: 5q34
Quick LinksEntrez ID:23286; OMIM: 610533; Uniprot ID:KIBRA_HUMAN; ENSEMBL ID: ENSG00000113645; HGNC ID: 29435
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst0 / 623190 
fetus16 / 56401228
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult82 / 193912142
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor3 / 3436687
chondrosarcoma5 / 8282360
colorectal tumor6 / 11424652
esophageal tumor0 / 172900 
gastrointestinal tumor7 / 11936958
germ cell tumor8 / 26384530
glioma6 / 10688356
head and neck tumor3 / 13630222
kidney tumor2 / 6895929
leukemia0 / 958420 
liver tumor7 / 9635972
lung tumor2 / 10312719
lymphoma6 / 7175583
non-neoplasia3 / 9725030
normal98 / 336030729
ovarian tumor10 / 76682130
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer5 / 10268048
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites4 / 4001599
bladder1 / 2975733
blood0 / 1234780 
bone2 / 7165527
bone marrow0 / 488010 
brain26 / 110098923
cervix4 / 4817183
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus0 / 202090 
eye8 / 21105437
heart0 / 896260 
intestine8 / 23447234
kidney18 / 21177784
larynx1 / 2414541
liver8 / 20774338
lung16 / 33697447
lymph6 / 44270135
lymph node0 / 916100 
mammary gland6 / 15327139
mouth1 / 6705214
muscle3 / 10771527
nerve1 / 1576863
ovary10 / 10205197
pancreas4 / 21481218
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta8 / 28082528
prostate12 / 18934563
salivary gland0 / 201550 
skin2 / 2105749
spleen2 / 5395237
stomach2 / 9661920
testis5 / 33044215
thymus1 / 8113112
thyroid3 / 4747363
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord0 / 136800 
uterus4 / 23287817
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 213085_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts25.25
Adipocyte17.2
AdrenalCortex22.95
Adrenalgland25.4
Amygdala38.25
Appendix17.8
AtrioventricularNode13.25
BDCA4+_DentriticCells15.75
Bonemarrow18.3
BronchialEpithelialCells17.05
CD105+_Endothelial16.35
CD14+_Monocytes16.05
CD19+_BCells(neg._sel.)14.15
CD33+_Myeloid14.95
CD34+21.5
CD4+_Tcells18.15
CD56+_NKCells10.55
CD71+_EarlyErythroid15.85
CD8+_Tcells10.3
CardiacMyocytes21.85
Caudatenucleus88.8
Cerebellum18.55
CerebellumPeduncles20.5
CiliaryGanglion12.85
CingulateCortex39
Colorectaladenocarcinoma258.55
DorsalRootGanglion13.8
FetalThyroid42.2
Fetalbrain253.5
Fetalliver14.95
Fetallung18.35
GlobusPallidus23.4
Heart21.45
Hypothalamus88.25
Kidney114.05
Leukemia_chronicMyelogenousK-56215.35
Leukemia_promyelocytic-HL-6015.7
Leukemialymphoblastic(MOLT-4)13.7
Liver22.75
Lung69.45
Lymphnode14.55
Lymphoma_burkitts(Daudi)22.2
Lymphoma_burkitts(Raji)16.2
MedullaOblongata26.2
OccipitalLobe52.05
OlfactoryBulb13.75
Ovary11.95
Pancreas26.5
PancreaticIslet131.65
ParietalLobe20.05
Pituitary19.8
Placenta60.4
Pons41.7
PrefrontalCortex61.2
Prostate79.15
Salivarygland133.45
SkeletalMuscle20.5
Skin18.55
SmoothMuscle19.45
Spinalcord100.05
SubthalamicNucleus33.25
SuperiorCervicalGanglion39.35
TemporalLobe29.2
Testis14.6
TestisGermCell14.1
TestisIntersitial14.85
TestisLeydigCell17.4
TestisSeminiferousTubule14.85
Thalamus88.55
Thymus13.3
Thyroid66.15
Tongue18.15
Tonsil16.8
Trachea38.6
TrigeminalGanglion17.9
Uterus14.05
UterusCorpus12.65
WholeBlood18.7
Wholebrain60.5
colon17.1
pineal_day18.66
pineal_night18.56
retina63.25
small_intestine16.55
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_10861_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.73 ± 0.46
Basal Forebrain6.44 ± 0.3
Basal Part of Pons6.13 ± 0.33
Cerebellar Cortex6.05 ± 0.26
Cerebellar Nuclei6.62 ± 0.42
Claustrum6.69 ± 0.89
Epithalamus6.99 ± 0.45
Frontal Lobe6.45 ± 0.37
Globus Pallidus7.09 ± 0.26
Hypothalamus5.76 ± 0.35
Insula6.49 ± 0.48
Limbic Lobe6.66 ± 0.47
Mesencephalon6.51 ± 0.54
Myelencephalon6.61 ± 0.54
Occipital Lobe6.47 ± 0.38
Parietal Lobe6.43 ± 0.5
Pontine Tegmentum6.6 ± 0.37
Striatum7.34 ± 0.46
Subthalamus6.6 ± 0.27
Temporal Lobe6.49 ± 0.48
Thalamus6.65 ± 0.34
White Matter6.09 ± 0.59
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Wwc1CBCerebellum21.98
28.21
Wwc1CTXCerebral cortex69.05
48.69
Wwc1HIPHippocampal region47.87
69.36
Wwc1HPFHippocampal formation45.61
49.76
Wwc1HYHypothalamus11.84
6.37
Wwc1LSXLateral septal complex26.46
16.95
Wwc1MBMidbrain15.37
10.66
Wwc1MYMedulla24.84
22
Wwc1OLFOlfactory bulb58.55
40.62
Wwc1PPons23.58
16.62
Wwc1PALPallidum16.15
9.03
Wwc1RHPRetrohippocampal region45.29
29.92
Wwc1sAMYStriatum-like amygdalar nuclei33.42
17.79
Wwc1STRStriatum35.5
17.95
Wwc1STRdStriatum dorsal region34.93
17.26
Wwc1STRvStriatum ventral region39.09
18.38
Wwc1THThalamus44.02
28.22
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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