AutismKB 2.0

Annotation Detail for FBXW11


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Basic Information Top
Gene Symbol:FBXW11 ( BTRC2,BTRCP2,FBW1B,FBXW1B,Fbw11,Hos,KIAA0696 )
Gene Full Name: F-box and WD repeat domain containing 11
Band: 5q35.1
Quick LinksEntrez ID:23291; OMIM: 605651; Uniprot ID:FBW1B_HUMAN; ENSEMBL ID: ENSG00000072803; HGNC ID: 13607
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst3 / 6231948
fetus27 / 56401247
neonate3 / 3109796
infant0 / 236200 
juvenile0 / 555560 
adult78 / 193912140
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma1 / 1747557
breast (mammary gland) tumor1 / 9417810
cervical tumor2 / 3436658
chondrosarcoma3 / 8282336
colorectal tumor3 / 11424626
esophageal tumor0 / 172900 
gastrointestinal tumor6 / 11936950
germ cell tumor9 / 26384534
glioma8 / 10688374
head and neck tumor2 / 13630214
kidney tumor2 / 6895929
leukemia1 / 9584210
liver tumor2 / 9635920
lung tumor0 / 1031270 
lymphoma4 / 7175555
non-neoplasia8 / 9725082
normal170 / 336030750
ovarian tumor3 / 7668239
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer2 / 10268019
retinoblastoma3 / 4635664
skin tumor8 / 12494964
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites1 / 4001524
bladder2 / 2975767
blood0 / 1234780 
bone5 / 7165569
bone marrow0 / 488010 
brain87 / 110098979
cervix6 / 48171124
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue19 / 21572288
esophagus0 / 202090 
eye8 / 21105437
heart3 / 8962633
intestine6 / 23447225
kidney7 / 21177733
larynx0 / 241450 
liver5 / 20774324
lung8 / 33697423
lymph3 / 4427067
lymph node6 / 9161065
mammary gland1 / 1532716
mouth0 / 670520 
muscle0 / 1077150 
nerve2 / 15768126
ovary4 / 10205139
pancreas15 / 21481269
parathyroid2 / 2053997
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta13 / 28082546
prostate8 / 18934542
salivary gland0 / 201550 
skin15 / 21057471
spleen4 / 5395274
stomach6 / 9661962
testis22 / 33044266
thymus2 / 8113124
thyroid2 / 4747342
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord2 / 13680146
uterus16 / 23287868
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209455_at
Cell line Expression level Expression bar
721_B_lymphoblasts192.35
Adipocyte21.85
AdrenalCortex26.95
Adrenalgland27
Amygdala190.6
Appendix24.7
AtrioventricularNode19.55
BDCA4+_DentriticCells108.2
Bonemarrow22.4
BronchialEpithelialCells50
CD105+_Endothelial37.2
CD14+_Monocytes36.35
CD19+_BCells(neg._sel.)148.4
CD33+_Myeloid46.55
CD34+60.5
CD4+_Tcells44.35
CD56+_NKCells116.95
CD71+_EarlyErythroid26.15
CD8+_Tcells38.65
CardiacMyocytes32.5
Caudatenucleus53.25
Cerebellum55.15
CerebellumPeduncles61.15
CiliaryGanglion18.25
CingulateCortex55.5
Colorectaladenocarcinoma62.9
DorsalRootGanglion22.45
FetalThyroid20.8
Fetalbrain72.75
Fetalliver18.65
Fetallung26.7
GlobusPallidus47.35
Heart26.85
Hypothalamus166.7
Kidney20.1
Leukemia_chronicMyelogenousK-56218.9
Leukemia_promyelocytic-HL-6040.6
Leukemialymphoblastic(MOLT-4)16.7
Liver31.05
Lung49.05
Lymphnode22.15
Lymphoma_burkitts(Daudi)35.5
Lymphoma_burkitts(Raji)54
MedullaOblongata94.7
OccipitalLobe84.6
OlfactoryBulb26.3
Ovary16.6
Pancreas20.3
PancreaticIslet50.6
ParietalLobe62.9
Pituitary40.55
Placenta28
Pons45.25
PrefrontalCortex102.45
Prostate42.35
Salivarygland23.55
SkeletalMuscle27.25
Skin28.65
SmoothMuscle33.9
Spinalcord161
SubthalamicNucleus43.7
SuperiorCervicalGanglion36.05
TemporalLobe36.35
Testis21.8
TestisGermCell27.1
TestisIntersitial15.45
TestisLeydigCell24.05
TestisSeminiferousTubule19.4
Thalamus93.85
Thymus17.9
Thyroid30.65
Tongue25.75
Tonsil24.2
Trachea20.05
TrigeminalGanglion42.5
Uterus50.5
UterusCorpus23.7
WholeBlood35.8
Wholebrain240.2
colon27.1
pineal_day123.32
pineal_night117.92
retina132.55
small_intestine54
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P257539
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.39 ± 0.4
Basal Forebrain7.49 ± 0.08
Basal Part of Pons7.49 ± 0.17
Cerebellar Cortex7.28 ± 0.18
Cerebellar Nuclei7.51 ± 0.09
Claustrum7.3 ± 0.27
Epithalamus7.26 ± 0.16
Frontal Lobe7.43 ± 0.19
Globus Pallidus7.75 ± 0.25
Hypothalamus7.42 ± 0.17
Insula7.47 ± 0.51
Limbic Lobe7.48 ± 0.26
Mesencephalon7.44 ± 0.25
Myelencephalon7.39 ± 0.23
Occipital Lobe7.25 ± 0.27
Parietal Lobe7.43 ± 0.23
Pontine Tegmentum7.38 ± 0.27
Striatum7.41 ± 0.27
Subthalamus7.63 ± 0.25
Temporal Lobe7.42 ± 0.22
Thalamus7.35 ± 0.27
White Matter7.99 ± 0.23
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Fbxw11CBCerebellum2.5
9.34
Fbxw11CTXCerebral cortex44.89
42.37
Fbxw11HIPHippocampal region80.35
100
Fbxw11HPFHippocampal formation57.06
86.04
Fbxw11HYHypothalamus18.73
16.88
Fbxw11LSXLateral septal complex27.82
23.78
Fbxw11MBMidbrain7.05
9.22
Fbxw11MYMedulla2.61
4.87
Fbxw11OLFOlfactory bulb22.87
27.81
Fbxw11PPons4.79
9
Fbxw11PALPallidum13.53
13.15
Fbxw11RHPRetrohippocampal region13.95
13.92
Fbxw11sAMYStriatum-like amygdalar nuclei16.49
14.52
Fbxw11STRStriatum9.91
8.53
Fbxw11STRdStriatum dorsal region6.75
5.97
Fbxw11STRvStriatum ventral region11.33
8.93
Fbxw11THThalamus40.81
39.06
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
FBW1B_HUMAN_11 10 11 20 TIELMCSVPR PRIDE
FBW1B_HUMAN_143 10 143 152 SLCAAELVCK PRIDE
FBW1B_HUMAN_157 9 157 165 VISEGMLWK PRIDE
FBW1B_HUMAN_194 13 194 206 NRPTDGPPNSFYR PRIDE
FBW1B_HUMAN_292 12 292 303 VIVTGSSDSTVR PRIDE
FBW1B_HUMAN_341 16 341 356 SIAVWDMASATDITLR PRIDE
FBW1B_HUMAN_47 15 47 61 CLQISNGTSSVIVSR PRIDE
FBW1B_HUMAN_478 9 478 486 APASTLCLR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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