AutismKB 2.0

Annotation Detail for FKBP15


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Basic Information Top
Gene Symbol:FKBP15 ( FKBP133,KIAA0674 )
Gene Full Name: FK506 binding protein 15, 133kDa
Band: 9q32
Quick LinksEntrez ID:23307; OMIM: NA; Uniprot ID:FKB15_HUMAN; ENSEMBL ID: ENSG00000119321; HGNC ID: 23397
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst1 / 6231916
fetus32 / 56401256
neonate7 / 31097225
infant1 / 2362042
juvenile0 / 555560 
adult102 / 193912152
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma2 / 17475114
breast (mammary gland) tumor10 / 94178106
cervical tumor2 / 3436658
chondrosarcoma8 / 8282396
colorectal tumor6 / 11424652
esophageal tumor0 / 172900 
gastrointestinal tumor5 / 11936941
germ cell tumor8 / 26384530
glioma4 / 10688337
head and neck tumor13 / 13630295
kidney tumor5 / 6895972
leukemia3 / 9584231
liver tumor7 / 9635972
lung tumor7 / 10312767
lymphoma3 / 7175541
non-neoplasia12 / 97250123
normal159 / 336030747
ovarian tumor0 / 766820 
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer0 / 1026800 
retinoblastoma2 / 4635643
skin tumor7 / 12494956
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites3 / 4001574
bladder0 / 297570 
blood10 / 12347880
bone8 / 71655111
bone marrow0 / 488010 
brain49 / 110098944
cervix2 / 4817141
connective tissue13 / 14925587
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus0 / 202090 
eye13 / 21105461
heart3 / 8962633
intestine10 / 23447242
kidney13 / 21177761
larynx2 / 2414582
liver10 / 20774348
lung25 / 33697474
lymph3 / 4427067
lymph node4 / 9161043
mammary gland12 / 15327178
mouth12 / 67052178
muscle3 / 10771527
nerve0 / 157680 
ovary1 / 1020519
pancreas2 / 2148129
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta11 / 28082539
prostate4 / 18934521
salivary gland0 / 201550 
skin10 / 21057447
spleen8 / 53952148
stomach2 / 9661920
testis11 / 33044233
thymus5 / 8113161
thyroid2 / 4747342
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord2 / 13680146
uterus8 / 23287834
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 76897_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.8
Adipocyte5.5
AdrenalCortex7.2
Adrenalgland5
Amygdala5.75
Appendix7.4
AtrioventricularNode6.15
BDCA4+_DentriticCells10.05
Bonemarrow6.15
BronchialEpithelialCells5.5
CD105+_Endothelial5.55
CD14+_Monocytes6.2
CD19+_BCells(neg._sel.)5.9
CD33+_Myeloid8.35
CD34+6.85
CD4+_Tcells5.9
CD56+_NKCells6.45
CD71+_EarlyErythroid5.55
CD8+_Tcells5.25
CardiacMyocytes11.75
Caudatenucleus5.1
Cerebellum4.65
CerebellumPeduncles7.2
CiliaryGanglion4.6
CingulateCortex5.9
Colorectaladenocarcinoma5.7
DorsalRootGanglion4.8
FetalThyroid6.6
Fetalbrain5.5
Fetalliver5
Fetallung4.4
GlobusPallidus4.5
Heart13.15
Hypothalamus5.95
Kidney4.95
Leukemia_chronicMyelogenousK-5625.05
Leukemia_promyelocytic-HL-605.05
Leukemialymphoblastic(MOLT-4)4.4
Liver8.8
Lung6.2
Lymphnode4.7
Lymphoma_burkitts(Daudi)7.65
Lymphoma_burkitts(Raji)8.7
MedullaOblongata5.05
OccipitalLobe5.05
OlfactoryBulb4.35
Ovary4.15
Pancreas4.75
PancreaticIslet6.1
ParietalLobe6.3
Pituitary6.6
Placenta5.6
Pons5.75
PrefrontalCortex6.8
Prostate6.45
Salivarygland4.8
SkeletalMuscle8.35
Skin4.9
SmoothMuscle6.4
Spinalcord6
SubthalamicNucleus6
SuperiorCervicalGanglion9.3
TemporalLobe5.6
Testis4.85
TestisGermCell4.45
TestisIntersitial4.95
TestisLeydigCell6.4
TestisSeminiferousTubule4.8
Thalamus6
Thymus4.3
Thyroid6.95
Tongue7.75
Tonsil5.65
Trachea4.7
TrigeminalGanglion7.4
Uterus4.5
UterusCorpus6.15
WholeBlood6.1
Wholebrain4.5
colon5.75
pineal_day6.9
pineal_night6.84
retina6.95
small_intestine5.5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P224149
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.32 ± 0.43
Basal Forebrain6.79 ± 0.2
Basal Part of Pons6.79 ± 0.29
Cerebellar Cortex7.05 ± 0.28
Cerebellar Nuclei6.87 ± 0.37
Claustrum6.35 ± 0.59
Epithalamus6.93 ± 0.32
Frontal Lobe6.82 ± 0.37
Globus Pallidus6.75 ± 0.13
Hypothalamus6.87 ± 0.26
Insula6.86 ± 0.28
Limbic Lobe6.63 ± 0.37
Mesencephalon6.76 ± 0.34
Myelencephalon6.74 ± 0.38
Occipital Lobe6.73 ± 0.36
Parietal Lobe6.72 ± 0.4
Pontine Tegmentum6.78 ± 0.44
Striatum6.55 ± 0.31
Subthalamus6.82 ± 0.14
Temporal Lobe6.82 ± 0.33
Thalamus6.8 ± 0.41
White Matter7.34 ± 0.33
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
C430014M02RikCBCerebellum100
100
C430014M02RikCTXCerebral cortex100
100
C430014M02RikHIPHippocampal region100
100
C430014M02RikHPFHippocampal formation100
100
C430014M02RikHYHypothalamus100
100
C430014M02RikLSXLateral septal complex100
100
C430014M02RikMBMidbrain100
100
C430014M02RikMYMedulla100
100
C430014M02RikOLFOlfactory bulb100
100
C430014M02RikPPons100
100
C430014M02RikPALPallidum100
100
C430014M02RikRHPRetrohippocampal region100
100
C430014M02RiksAMYStriatum-like amygdalar nuclei100
100
C430014M02RikSTRStriatum100
100
C430014M02RikSTRdStriatum dorsal region100
100
C430014M02RikSTRvStriatum ventral region100
100
C430014M02RikTHThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00001573 14 818 831 DEHLQQYQEVCAQR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018