AutismKB 2.0

Annotation Detail for SIN3B


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Basic Information Top
Gene Symbol:SIN3B ( KIAA0700 )
Gene Full Name: SIN3 homolog B, transcription regulator (yeast)
Band: 19p13.12
Quick LinksEntrez ID:23309; OMIM: 607777; Uniprot ID:SIN3B_HUMAN; ENSEMBL ID: ENSG00000127511; HGNC ID: 19354
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body9 / 70761127
blastocyst9 / 62319144
fetus38 / 56401267
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult103 / 193912153
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor2 / 9417821
cervical tumor2 / 3436658
chondrosarcoma5 / 8282360
colorectal tumor0 / 1142460 
esophageal tumor1 / 1729057
gastrointestinal tumor3 / 11936925
germ cell tumor5 / 26384518
glioma5 / 10688346
head and neck tumor2 / 13630214
kidney tumor4 / 6895958
leukemia3 / 9584231
liver tumor4 / 9635941
lung tumor1 / 1031279
lymphoma4 / 7175555
non-neoplasia2 / 9725020
normal199 / 336030759
ovarian tumor1 / 7668213
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer2 / 10268019
retinoblastoma1 / 4635621
skin tumor8 / 12494964
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites2 / 4001549
bladder1 / 2975733
blood5 / 12347840
bone1 / 7165513
bone marrow0 / 488010 
brain56 / 110098950
cervix4 / 4817183
connective tissue6 / 14925540
ear0 / 162120 
embryonic tissue21 / 21572297
esophagus1 / 2020949
eye9 / 21105442
heart6 / 8962666
intestine2 / 2344728
kidney5 / 21177723
larynx0 / 241450 
liver7 / 20774333
lung11 / 33697432
lymph1 / 4427022
lymph node11 / 91610120
mammary gland6 / 15327139
mouth2 / 6705229
muscle2 / 10771518
nerve2 / 15768126
ovary2 / 10205119
pancreas4 / 21481218
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta30 / 280825106
prostate4 / 18934521
salivary gland0 / 201550 
skin11 / 21057452
spleen2 / 5395237
stomach0 / 966190 
testis24 / 33044272
thymus3 / 8113136
thyroid0 / 474730 
tonsil1 / 1699958
trachea1 / 5241319
umbilical cord0 / 136800 
uterus13 / 23287855
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209352_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts9.35
Adipocyte7.85
AdrenalCortex10.55
Adrenalgland11.9
Amygdala115.5
Appendix7.35
AtrioventricularNode5.75
BDCA4+_DentriticCells10
Bonemarrow7.85
BronchialEpithelialCells6.95
CD105+_Endothelial7.3
CD14+_Monocytes22.2
CD19+_BCells(neg._sel.)19.95
CD33+_Myeloid33.6
CD34+10.5
CD4+_Tcells18.85
CD56+_NKCells9.15
CD71+_EarlyErythroid6.7
CD8+_Tcells34.15
CardiacMyocytes9.25
Caudatenucleus10.1
Cerebellum13.95
CerebellumPeduncles9.2
CiliaryGanglion5.2
CingulateCortex11.65
Colorectaladenocarcinoma7.65
DorsalRootGanglion5.95
FetalThyroid11.15
Fetalbrain26.9
Fetalliver6.7
Fetallung14.6
GlobusPallidus10.25
Heart10
Hypothalamus11.85
Kidney6.2
Leukemia_chronicMyelogenousK-5627.7
Leukemia_promyelocytic-HL-606.8
Leukemialymphoblastic(MOLT-4)6.6
Liver9.85
Lung37.7
Lymphnode9.95
Lymphoma_burkitts(Daudi)11.6
Lymphoma_burkitts(Raji)126.2
MedullaOblongata14.6
OccipitalLobe15.05
OlfactoryBulb8.7
Ovary5.25
Pancreas5.9
PancreaticIslet8.35
ParietalLobe10.15
Pituitary9.55
Placenta77.8
Pons7.6
PrefrontalCortex144.3
Prostate17.8
Salivarygland6
SkeletalMuscle8.6
Skin5.8
SmoothMuscle9.4
Spinalcord10.2
SubthalamicNucleus9.4
SuperiorCervicalGanglion9.15
TemporalLobe9.4
Testis22.05
TestisGermCell36.45
TestisIntersitial13.05
TestisLeydigCell10.65
TestisSeminiferousTubule12.85
Thalamus9.4
Thymus6.6
Thyroid43.65
Tongue7.3
Tonsil7.4
Trachea6
TrigeminalGanglion7.6
Uterus33.55
UterusCorpus7.15
WholeBlood8.7
Wholebrain42.3
colon7.2
pineal_day9.76
pineal_night10.28
retina9.8
small_intestine6.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_939_PI416573500
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.27 ± 0.9
Basal Forebrain2.61 ± 0.47
Basal Part of Pons2.64 ± 0.56
Cerebellar Cortex2.98 ± 0.65
Cerebellar Nuclei3.03 ± 0.57
Claustrum3.2 ± 0.66
Epithalamus2.6 ± 0.86
Frontal Lobe2.92 ± 0.75
Globus Pallidus2.69 ± 0.59
Hypothalamus2.88 ± 0.57
Insula3.23 ± 0.42
Limbic Lobe3 ± 0.64
Mesencephalon3.09 ± 0.76
Myelencephalon2.97 ± 0.65
Occipital Lobe2.79 ± 0.6
Parietal Lobe2.94 ± 0.7
Pontine Tegmentum2.95 ± 0.59
Striatum2.36 ± 0.63
Subthalamus2.96 ± 0.76
Temporal Lobe3.06 ± 0.73
Thalamus2.75 ± 0.66
White Matter2.69 ± 0.61
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Sin3bCBCerebellum43.33
72.43
Sin3bCTXCerebral cortex100
100
Sin3bHIPHippocampal region100
100
Sin3bHPFHippocampal formation100
100
Sin3bHYHypothalamus100
99.02
Sin3bLSXLateral septal complex100
100
Sin3bMBMidbrain100
100
Sin3bMYMedulla86.29
100
Sin3bOLFOlfactory bulb99.02
100
Sin3bPPons82.55
95.24
Sin3bPALPallidum87.87
92.91
Sin3bRHPRetrohippocampal region100
100
Sin3bsAMYStriatum-like amygdalar nuclei100
100
Sin3bSTRStriatum100
95.81
Sin3bSTRdStriatum dorsal region100
95.01
Sin3bSTRvStriatum ventral region100
83.22
Sin3bTHThalamus100
96.87
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00097039 15 1136 1150 TLCETVHVHGLPVTR Peptide Atlas
SIN3B_HUMAN_566 8 566 573 AVPVVLKR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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