AutismKB 2.0

Annotation Detail for DMXL2


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Basic Information Top
Gene Symbol:DMXL2 ( FLJ26672,KIAA0856,RC3 )
Gene Full Name: Dmx-like 2
Band: 15q21.2
Quick LinksEntrez ID:23312; OMIM: 612186; Uniprot ID:DMXL2_HUMAN; ENSEMBL ID: ENSG00000104093; HGNC ID: 2938
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst1 / 6231916
fetus26 / 56401246
neonate0 / 310970 
infant0 / 236200 
juvenile2 / 5555635
adult70 / 193912136
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma3 / 8282336
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor3 / 11936925
germ cell tumor13 / 26384549
glioma1 / 1068839
head and neck tumor3 / 13630222
kidney tumor3 / 6895943
leukemia9 / 9584293
liver tumor1 / 9635910
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia3 / 9725030
normal157 / 336030746
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer1 / 1026809
retinoblastoma1 / 4635621
skin tumor1 / 1249498
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites2 / 4001549
bladder0 / 297570 
blood10 / 12347880
bone3 / 7165541
bone marrow1 / 4880120
brain77 / 110098969
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue5 / 21572223
esophagus0 / 202090 
eye3 / 21105414
heart5 / 8962655
intestine4 / 23447217
kidney10 / 21177747
larynx0 / 241450 
liver2 / 2077439
lung14 / 33697441
lymph0 / 442700 
lymph node2 / 9161021
mammary gland4 / 15327126
mouth2 / 6705229
muscle6 / 10771555
nerve1 / 1576863
ovary0 / 1020510 
pancreas8 / 21481237
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland2 / 16585120
placenta1 / 2808253
prostate4 / 18934521
salivary gland0 / 201550 
skin2 / 2105749
spleen0 / 539520 
stomach1 / 9661910
testis14 / 33044242
thymus2 / 8113124
thyroid1 / 4747321
tonsil0 / 169990 
trachea3 / 5241357
umbilical cord0 / 136800 
uterus5 / 23287821
vascular7 / 51780135
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 212820_at
Cell line Expression level Expression bar
721_B_lymphoblasts44.85
Adipocyte6.2
AdrenalCortex8.65
Adrenalgland6.45
Amygdala232.65
Appendix9.1
AtrioventricularNode6.45
BDCA4+_DentriticCells82.75
Bonemarrow8.35
BronchialEpithelialCells6.2
CD105+_Endothelial9.05
CD14+_Monocytes276.95
CD19+_BCells(neg._sel.)8.25
CD33+_Myeloid345.6
CD34+11.6
CD4+_Tcells8.35
CD56+_NKCells17.55
CD71+_EarlyErythroid6.15
CD8+_Tcells6.8
CardiacMyocytes10.95
Caudatenucleus24.95
Cerebellum7.2
CerebellumPeduncles10.35
CiliaryGanglion5.9
CingulateCortex29.45
Colorectaladenocarcinoma8
DorsalRootGanglion6.9
FetalThyroid8
Fetalbrain80.5
Fetalliver7.85
Fetallung18.9
GlobusPallidus18.15
Heart11.25
Hypothalamus49.75
Kidney6.05
Leukemia_chronicMyelogenousK-56253.45
Leukemia_promyelocytic-HL-606.1
Leukemialymphoblastic(MOLT-4)11.85
Liver10.05
Lung6.75
Lymphnode14.65
Lymphoma_burkitts(Daudi)7.1
Lymphoma_burkitts(Raji)11.75
MedullaOblongata21.2
OccipitalLobe40.85
OlfactoryBulb6.7
Ovary5.75
Pancreas6.5
PancreaticIslet8.4
ParietalLobe15.3
Pituitary10.6
Placenta5.25
Pons10.15
PrefrontalCortex109.8
Prostate9.65
Salivarygland5.8
SkeletalMuscle9.65
Skin6.35
SmoothMuscle9.65
Spinalcord16.7
SubthalamicNucleus31.65
SuperiorCervicalGanglion10.25
TemporalLobe10.3
Testis6.95
TestisGermCell11.85
TestisIntersitial7.5
TestisLeydigCell9
TestisSeminiferousTubule8.25
Thalamus24.6
Thymus5.05
Thyroid12.85
Tongue8.05
Tonsil8
Trachea6.75
TrigeminalGanglion9.15
Uterus11.8
UterusCorpus7.15
WholeBlood112.5
Wholebrain23.6
colon15
pineal_day135.5
pineal_night144.22
retina11.125
small_intestine8.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_13585_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.62 ± 0.35
Basal Forebrain7.37 ± 0.19
Basal Part of Pons7.8 ± 0.2
Cerebellar Cortex7.77 ± 0.21
Cerebellar Nuclei7.42 ± 0.35
Claustrum7.41 ± 0.27
Epithalamus7.37 ± 0.25
Frontal Lobe7.68 ± 0.33
Globus Pallidus6.62 ± 0.23
Hypothalamus7.53 ± 0.23
Insula7.57 ± 0.34
Limbic Lobe7.82 ± 0.4
Mesencephalon7.54 ± 0.38
Myelencephalon7.53 ± 0.38
Occipital Lobe7.64 ± 0.35
Parietal Lobe7.66 ± 0.35
Pontine Tegmentum7.58 ± 0.37
Striatum7.22 ± 0.37
Subthalamus7.53 ± 0.24
Temporal Lobe7.78 ± 0.26
Thalamus7.4 ± 0.25
White Matter6.45 ± 0.31
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Dmxl2CBCerebellum34.03
37.8
Dmxl2CTXCerebral cortex100
100
Dmxl2HIPHippocampal region81.9
100
Dmxl2HPFHippocampal formation89.2
100
Dmxl2HYHypothalamus46.43
42.88
Dmxl2LSXLateral septal complex38.93
29.68
Dmxl2MBMidbrain53.18
56.59
Dmxl2MYMedulla55.3
74.29
Dmxl2OLFOlfactory bulb94.99
91.8
Dmxl2PPons45.61
59.52
Dmxl2PALPallidum43.04
43.68
Dmxl2RHPRetrohippocampal region100
98.54
Dmxl2sAMYStriatum-like amygdalar nuclei70.59
57.59
Dmxl2STRStriatum53.01
42.53
Dmxl2STRdStriatum dorsal region49.55
39.99
Dmxl2STRvStriatum ventral region63.11
49.22
Dmxl2THThalamus67
66.26
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00069400 17 55 71 HGNIQVSCVECSNQQGR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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