AutismKB 2.0

Annotation Detail for CUX2


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Basic Information Top
Gene Symbol:CUX2 ( CDP2,CUTL2 )
Gene Full Name: cut-like homeobox 2
Band: 12q24.11-q24.12
Quick LinksEntrez ID:23316; OMIM: 610648; Uniprot ID:CUX2_HUMAN; ENSEMBL ID: ENSG00000111249; HGNC ID: 19347
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst2 / 6231932
fetus7 / 56401212
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult19 / 19391219
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor2 / 2638457
glioma1 / 1068839
head and neck tumor3 / 13630222
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma1 / 7175513
non-neoplasia1 / 9725010
normal33 / 33603079
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer2 / 10268019
retinoblastoma3 / 4635664
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain8 / 11009897
cervix0 / 481710 
connective tissue0 / 1492550 
ear1 / 1621261
embryonic tissue2 / 2157229
esophagus0 / 202090 
eye7 / 21105433
heart0 / 896260 
intestine0 / 2344720 
kidney0 / 2117770 
larynx0 / 241450 
liver1 / 2077434
lung0 / 3369740 
lymph1 / 4427022
lymph node0 / 916100 
mammary gland1 / 1532716
mouth2 / 6705229
muscle1 / 1077159
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate5 / 18934526
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis8 / 33044224
thymus0 / 811310 
thyroid1 / 4747321
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 213920_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.65
Adipocyte6.35
AdrenalCortex8.6
Adrenalgland5.85
Amygdala7
Appendix7.3
AtrioventricularNode6.6
BDCA4+_DentriticCells365.25
Bonemarrow6.7
BronchialEpithelialCells6.45
CD105+_Endothelial6.55
CD14+_Monocytes7
CD19+_BCells(neg._sel.)6.75
CD33+_Myeloid7.85
CD34+7.95
CD4+_Tcells6.5
CD56+_NKCells7.15
CD71+_EarlyErythroid6.3
CD8+_Tcells5.75
CardiacMyocytes8.95
Caudatenucleus5.95
Cerebellum5.5
CerebellumPeduncles8.1
CiliaryGanglion6.25
CingulateCortex21.5
Colorectaladenocarcinoma6.55
DorsalRootGanglion5.8
FetalThyroid6.6
Fetalbrain137.2
Fetalliver5.75
Fetallung4.9
GlobusPallidus9.55
Heart8.8
Hypothalamus7.6
Kidney5.75
Leukemia_chronicMyelogenousK-5625.9
Leukemia_promyelocytic-HL-605.85
Leukemialymphoblastic(MOLT-4)5.1
Liver22
Lung7.1
Lymphnode5.5
Lymphoma_burkitts(Daudi)8.85
Lymphoma_burkitts(Raji)9.8
MedullaOblongata8.5
OccipitalLobe14.5
OlfactoryBulb5.05
Ovary4.75
Pancreas5.4
PancreaticIslet7.05
ParietalLobe12
Pituitary8
Placenta6.4
Pons6.7
PrefrontalCortex10.35
Prostate10.7
Salivarygland5.45
SkeletalMuscle9.9
Skin6.15
SmoothMuscle7.35
Spinalcord7.05
SubthalamicNucleus19.4
SuperiorCervicalGanglion10.6
TemporalLobe9.65
Testis5.65
TestisGermCell5.1
TestisIntersitial5.6
TestisLeydigCell7.1
TestisSeminiferousTubule5.6
Thalamus19.7
Thymus4.85
Thyroid8.4
Tongue7.4
Tonsil6.55
Trachea5.45
TrigeminalGanglion7.6
Uterus5.05
UterusCorpus6.45
WholeBlood7
Wholebrain34.1
colon6.5
pineal_day33.04
pineal_night34.3
retina7.875
small_intestine6.2
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P281908
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.45 ± 0.95
Basal Forebrain4.3 ± 0.7
Basal Part of Pons3.82 ± 0.59
Cerebellar Cortex4.28 ± 0.6
Cerebellar Nuclei4.34 ± 0.62
Claustrum5.64 ± 0.63
Epithalamus4.17 ± 0.65
Frontal Lobe4.76 ± 0.74
Globus Pallidus3.77 ± 0.83
Hypothalamus4.31 ± 0.5
Insula5.14 ± 0.63
Limbic Lobe4.41 ± 0.71
Mesencephalon4.82 ± 0.83
Myelencephalon4.77 ± 0.88
Occipital Lobe5.68 ± 0.93
Parietal Lobe5.06 ± 0.75
Pontine Tegmentum5.2 ± 0.74
Striatum3.38 ± 1.36
Subthalamus4.25 ± 1.39
Temporal Lobe5.13 ± 0.53
Thalamus5.65 ± 0.65
White Matter3.17 ± 0.51
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Cutl2CBCerebellum63.92
85.61
Cutl2CTXCerebral cortex100
100
Cutl2HIPHippocampal region33.62
46.02
Cutl2HPFHippocampal formation57
77.99
Cutl2HYHypothalamus57.58
51.22
Cutl2LSXLateral septal complex38.99
32.03
Cutl2MBMidbrain73.93
73.78
Cutl2MYMedulla72.8
87.79
Cutl2OLFOlfactory bulb87.1
99.6
Cutl2PPons68.14
76.07
Cutl2PALPallidum52.76
54.75
Cutl2RHPRetrohippocampal region90.93
100
Cutl2sAMYStriatum-like amygdalar nuclei70.03
64.6
Cutl2STRStriatum48.28
46.04
Cutl2STRdStriatum dorsal region31.82
27.04
Cutl2STRvStriatum ventral region85.69
88.27
Cutl2THThalamus100
100
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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