Annotation Detail for NEDD4L
Basic Information Top
| Gene Symbol: | NEDD4L ( FLJ33870,KIAA0439,NEDD4-2,RSP5,hNedd4-2 ) |
|---|---|
| Gene Full Name: | neural precursor cell expressed, developmentally down-regulated 4-like |
| Band: | 18q21.31 |
| Quick Links | Entrez ID:23327; OMIM: 606384; Uniprot ID:NED4L_HUMAN; ENSEMBL ID: ENSG00000049759; HGNC ID: 7728 |
| Relate to Another Database: | SFARIGene; denovo-db |
- Unigene ID: Hs.185677
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
 | |||
| embryoid body | 3 / 70761 | 42 |  |
| blastocyst | 5 / 62319 | 80 |  |
| fetus | 102 / 564012 | 180 | |
| neonate | 1 / 31097 | 32 | |
| infant | 0 / 23620 | 0 | |
| juvenile | 5 / 55556 | 89 | |
| adult | 163 / 1939121 | 84 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adrenal tumor | 0 / 12794 | 0 | |
| bladder carcinoma | 4 / 17475 | 228 |  |
| breast (mammary gland) tumor | 5 / 94178 | 53 | |
| cervical tumor | 1 / 34366 | 29 | |
| chondrosarcoma | 6 / 82823 | 72 | |
| colorectal tumor | 11 / 114246 | 96 | |
| esophageal tumor | 1 / 17290 | 57 | |
| gastrointestinal tumor | 3 / 119369 | 25 | |
| germ cell tumor | 14 / 263845 | 53 | |
| glioma | 9 / 106883 | 84 | |
| head and neck tumor | 14 / 136302 | 102 | |
| kidney tumor | 1 / 68959 | 14 | |
| leukemia | 4 / 95842 | 41 | |
| liver tumor | 25 / 96359 | 259 | |
| lung tumor | 6 / 103127 | 58 | |
| lymphoma | 0 / 71755 | 0 | |
| non-neoplasia | 1 / 97250 | 10 |  |
| normal | 335 / 3360307 | 99 | |
| ovarian tumor | 1 / 76682 | 13 | |
| pancreatic tumor | 4 / 104616 | 38 | |
| primitive neuroectodermal tumor of the CNS | 3 / 125680 | 23 | |
| prostate cancer | 17 / 102680 | 165 | |
| retinoblastoma | 1 / 46356 | 21 | |
| skin tumor | 30 / 124949 | 240 | |
| soft tissue/muscle tissue tumor | 6 / 125191 | 47 | |
| uterine tumor | 6 / 90257 | 66 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adipose tissue | 0 / 13106 | 0 | |
| adrenal gland | 4 / 33197 | 120 | |
| ascites | 1 / 40015 | 24 | |
| bladder | 2 / 29757 | 67 | |
| blood | 4 / 123478 | 32 | |
| bone | 3 / 71655 | 41 | |
| bone marrow | 1 / 48801 | 20 | |
| brain | 106 / 1100989 | 96 | |
| cervix | 1 / 48171 | 20 | |
| connective tissue | 10 / 149255 | 66 | |
| ear | 0 / 16212 | 0 | |
| embryonic tissue | 13 / 215722 | 60 | |
| esophagus | 1 / 20209 | 49 | |
| eye | 25 / 211054 | 118 | |
| heart | 9 / 89626 | 100 | |
| intestine | 18 / 234472 | 76 | |
| kidney | 26 / 211777 | 122 | |
| larynx | 3 / 24145 | 124 | |
| liver | 32 / 207743 | 154 | |
| lung | 30 / 336974 | 89 | |
| lymph | 0 / 44270 | 0 | |
| lymph node | 3 / 91610 | 32 | |
| mammary gland | 13 / 153271 | 84 | |
| mouth | 8 / 67052 | 119 | |
| muscle | 7 / 107715 | 64 | |
| nerve | 0 / 15768 | 0 | |
| ovary | 2 / 102051 | 19 | |
| pancreas | 10 / 214812 | 46 | |
| parathyroid | 0 / 20539 | 0 | |
| pharynx | 2 / 41328 | 48 | |
| pituitary gland | 1 / 16585 | 60 | |
| placenta | 17 / 280825 | 60 | |
| prostate | 42 / 189345 | 221 | |
| salivary gland | 3 / 20155 | 148 | |
| skin | 37 / 210574 | 175 | |
| spleen | 1 / 53952 | 18 | |
| stomach | 2 / 96619 | 20 | |
| testis | 9 / 330442 | 27 | |
| thymus | 0 / 81131 | 0 | |
| thyroid | 3 / 47473 | 63 | |
| tonsil | 0 / 16999 | 0 | |
| trachea | 7 / 52413 | 133 | |
| umbilical cord | 1 / 13680 | 73 | |
| uterus | 6 / 232878 | 25 | |
| vascular | 1 / 51780 | 19 | |
- Microarray Platform: GeneAtlas U133A, gcrma
- Affymatrix Probe ID: 212445_s_at
| Cell line | Expression level | Expression bar |
|---|---|---|
| ||
| 721_B_lymphoblasts | 47.6 | |
| Adipocyte | 4.55 | |
| AdrenalCortex | 4.75 | |
| Adrenalgland | 3.95 | |
| Amygdala | 5.25 | |
| Appendix | 4.6 | |
| AtrioventricularNode | 3.5 | |
| BDCA4+_DentriticCells | 4.95 | |
| Bonemarrow | 4.5 | |
| BronchialEpithelialCells | 5 | |
| CD105+_Endothelial | 4.7 | |
| CD14+_Monocytes | 4.8 | |
| CD19+_BCells(neg._sel.) | 4.95 | |
| CD33+_Myeloid | 5.7 | |
| CD34+ | 5.95 | |
| CD4+_Tcells | 4.9 | |
| CD56+_NKCells | 5.3 | |
| CD71+_EarlyErythroid | 11.9 | |
| CD8+_Tcells | 4.3 | |
| CardiacMyocytes | 5.75 | |
| Caudatenucleus | 4.2 | |
| Cerebellum | 3.75 | |
| CerebellumPeduncles | 5.45 | |
| CiliaryGanglion | 3.2 | |
| CingulateCortex | 4.75 | |
| Colorectaladenocarcinoma | 4.65 | |
| DorsalRootGanglion | 3.5 | |
| FetalThyroid | 4.5 | |
| Fetalbrain | 5.55 | |
| Fetalliver | 4.45 | |
| Fetallung | 30.2 | |
| GlobusPallidus | 3.4 | |
| Heart | 5.85 | |
| Hypothalamus | 5.1 | |
| Kidney | 5.2 | |
| Leukemia_chronicMyelogenousK-562 | 4.2 | |
| Leukemia_promyelocytic-HL-60 | 4.4 | |
| Leukemialymphoblastic(MOLT-4) | 3.75 | |
| Liver | 6.1 | |
| Lung | 12.3 | |
| Lymphnode | 3.85 | |
| Lymphoma_burkitts(Daudi) | 5.9 | |
| Lymphoma_burkitts(Raji) | 6.4 | |
| MedullaOblongata | 4.5 | |
| OccipitalLobe | 4.25 | |
| OlfactoryBulb | 3.6 | |
| Ovary | 3.05 | |
| Pancreas | 3.75 | |
| PancreaticIslet | 5.25 | |
| ParietalLobe | 4.95 | |
| Pituitary | 5.45 | |
| Placenta | 5 | |
| Pons | 4.45 | |
| PrefrontalCortex | 5.7 | |
| Prostate | 129.6 | |
| Salivarygland | 3.8 | |
| SkeletalMuscle | 5.3 | |
| Skin | 3.55 | |
| SmoothMuscle | 5.3 | |
| Spinalcord | 4.95 | |
| SubthalamicNucleus | 4.3 | |
| SuperiorCervicalGanglion | 5.15 | |
| TemporalLobe | 4.2 | |
| Testis | 4.05 | |
| TestisGermCell | 3.85 | |
| TestisIntersitial | 3.9 | |
| TestisLeydigCell | 4.55 | |
| TestisSeminiferousTubule | 3.9 | |
| Thalamus | 4.7 | |
| Thymus | 3.6 | |
| Thyroid | 5.8 | |
| Tongue | 4.5 | |
| Tonsil | 4.5 | |
| Trachea | 4 | |
| TrigeminalGanglion | 4.55 | |
| Uterus | 3.8 | |
| UterusCorpus | 4.15 | |
| WholeBlood | 5.05 | |
| Wholebrain | 4.25 | |
| colon | 6.2 | |
| pineal_day | 8.68 | |
| pineal_night | 20.06 | |
| retina | 6.2 | |
| small_intestine | 4.65 | |
- Probe name: A_23_P27279
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 6.5 ± 0.49 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 6.36 ± 0.4 | |
| Basal Part of Pons | 6.48 ± 0.49 | |
| Cerebellar Cortex | 6.55 ± 0.19 | |
| Cerebellar Nuclei | 6.1 ± 0.41 | |
| Claustrum | 6.67 ± 0.45 | |
| Epithalamus | 6.28 ± 0.48 | |
| Frontal Lobe | 6.66 ± 0.4 | |
| Globus Pallidus | 5.13 ± 0.69 | |
| Hypothalamus | 6.27 ± 0.56 | |
| Insula | 6.75 ± 0.23 | |
| Limbic Lobe | 6.8 ± 0.57 | |
| Mesencephalon | 6.44 ± 0.59 | |
| Myelencephalon | 6.51 ± 0.42 | |
| Occipital Lobe | 6.19 ± 0.58 | |
| Parietal Lobe | 6.49 ± 0.42 | |
| Pontine Tegmentum | 6.48 ± 0.52 | |
| Striatum | 6.72 ± 0.32 | |
| Subthalamus | 6.71 ± 0.33 | |
| Temporal Lobe | 6.76 ± 0.4 | |
| Thalamus | 6.31 ± 0.41 | |
| White Matter | 4.59 ± 0.16 | |
Mouse Brain ISH 
| Gene Symbol | Brain Structure ID | Brain Structure Name | Express Desity/Level (Meatured by ISH) | Express Bar |
|---|---|---|---|---|
| Nedd4l | CB | Cerebellum | 45.62 | |
| 53.7 | | |||
| Nedd4l | CTX | Cerebral cortex | 100 | |
| 100 | | |||
| Nedd4l | HIP | Hippocampal region | 100 | |
| 100 | | |||
| Nedd4l | HPF | Hippocampal formation | 100 | |
| 100 | | |||
| Nedd4l | HY | Hypothalamus | 14.1 | |
| 12.15 | | |||
| Nedd4l | LSX | Lateral septal complex | 46.48 | |
| 42.46 | | |||
| Nedd4l | MB | Midbrain | 17.26 | |
| 17.43 | | |||
| Nedd4l | MY | Medulla | 8.3 | |
| 9.43 | | |||
| Nedd4l | OLF | Olfactory bulb | 86.98 | |
| 93.6 | | |||
| Nedd4l | P | Pons | 12.24 | |
| 12.59 | | |||
| Nedd4l | PAL | Pallidum | 26.17 | |
| 28.61 | | |||
| Nedd4l | RHP | Retrohippocampal region | 94.24 | |
| 93.52 | | |||
| Nedd4l | sAMY | Striatum-like amygdalar nuclei | 69.14 | |
| 61.85 | | |||
| Nedd4l | STR | Striatum | 100 | |
| 100 | | |||
| Nedd4l | STRd | Striatum dorsal region | 100 | |
| 100 | | |||
| Nedd4l | STRv | Striatum ventral region | 100 | |
| 100 | | |||
| Nedd4l | TH | Thalamus | 56.53 | |
| 52.65 | |
| Peptide Name | Peptide Lengh | Peptide Start | Peptide End | Peptide Sequence | Source |
|---|---|---|---|---|---|
| NED4L_HUMAN_2 | 19 | 2 | 20 | ATGLGEPVYGLSEDEGESR | PRIDE |
| PAp00028982 | 7 | 959 | 965 | AHTCFNR | Peptide Atlas |