AutismKB 2.0

Annotation Detail for SYNM


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Basic Information Top
Gene Symbol:SYNM ( DMN,KIAA0353,SYN )
Gene Full Name: synemin, intermediate filament protein
Band: 15q26.3
Quick LinksEntrez ID:23336; OMIM: 606087; Uniprot ID:SYNEM_HUMAN; ENSEMBL ID: ENSG00000182253; HGNC ID: 24466
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus7 / 56401212
neonate0 / 310970 
infant0 / 236200 
juvenile3 / 5555653
adult91 / 193912146
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor1 / 3436629
chondrosarcoma1 / 8282312
colorectal tumor2 / 11424617
esophageal tumor1 / 1729057
gastrointestinal tumor2 / 11936916
germ cell tumor1 / 2638453
glioma4 / 10688337
head and neck tumor2 / 13630214
kidney tumor2 / 6895929
leukemia1 / 9584210
liver tumor1 / 9635910
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal151 / 336030744
ovarian tumor3 / 7668239
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood2 / 12347816
bone0 / 716550 
bone marrow0 / 488010 
brain46 / 110098941
cervix1 / 4817120
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus3 / 20209148
eye12 / 21105456
heart8 / 8962689
intestine39 / 234472166
kidney8 / 21177737
larynx3 / 24145124
liver2 / 2077439
lung2 / 3369745
lymph0 / 442700 
lymph node0 / 916100 
mammary gland6 / 15327139
mouth2 / 6705229
muscle9 / 10771583
nerve4 / 15768253
ovary4 / 10205139
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland2 / 16585120
placenta2 / 2808257
prostate24 / 189345126
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach6 / 9661962
testis5 / 33044215
thymus1 / 8113112
thyroid0 / 474730 
tonsil0 / 169990 
trachea4 / 5241376
umbilical cord0 / 136800 
uterus17 / 23287872
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 212730_at
Cell line Expression level Expression bar
721_B_lymphoblasts10.2
Adipocyte48.8
AdrenalCortex68.1
Adrenalgland54.8
Amygdala78.6
Appendix509.95
AtrioventricularNode62.8
BDCA4+_DentriticCells6.85
Bonemarrow32.65
BronchialEpithelialCells9.05
CD105+_Endothelial7.2
CD14+_Monocytes7.85
CD19+_BCells(neg._sel.)6.65
CD33+_Myeloid12.95
CD34+8.75
CD4+_Tcells10.5
CD56+_NKCells8
CD71+_EarlyErythroid22.7
CD8+_Tcells10.25
CardiacMyocytes10.05
Caudatenucleus99.9
Cerebellum41.8
CerebellumPeduncles43.9
CiliaryGanglion106.85
CingulateCortex157.75
Colorectaladenocarcinoma18.5
DorsalRootGanglion54.75
FetalThyroid49.6
Fetalbrain61.35
Fetalliver27.2
Fetallung22.25
GlobusPallidus60.75
Heart148
Hypothalamus418.7
Kidney18.55
Leukemia_chronicMyelogenousK-56219.25
Leukemia_promyelocytic-HL-608.5
Leukemialymphoblastic(MOLT-4)16.3
Liver50.7
Lung40.65
Lymphnode35.85
Lymphoma_burkitts(Daudi)16.1
Lymphoma_burkitts(Raji)17.35
MedullaOblongata127.85
OccipitalLobe148.9
OlfactoryBulb228.75
Ovary61.95
Pancreas29.95
PancreaticIslet36.3
ParietalLobe115.35
Pituitary172.8
Placenta42
Pons87.65
PrefrontalCortex370.15
Prostate1046.95
Salivarygland36.9
SkeletalMuscle785.5
Skin55.1
SmoothMuscle15.8
Spinalcord536
SubthalamicNucleus76.7
SuperiorCervicalGanglion88.3
TemporalLobe95.5
Testis33.5
TestisGermCell306.6
TestisIntersitial26.4
TestisLeydigCell104.7
TestisSeminiferousTubule29.7
Thalamus193.2
Thymus15.15
Thyroid77.4
Tongue263.9
Tonsil30.2
Trachea123.6
TrigeminalGanglion109.45
Uterus114.05
UterusCorpus30.75
WholeBlood25.2
Wholebrain122.3
colon1753.75
pineal_day670.94
pineal_night703
retina938.225
small_intestine1537.25
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_7005_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.58 ± 0.25
Basal Forebrain9.17 ± 0.28
Basal Part of Pons8.84 ± 0.21
Cerebellar Cortex8.52 ± 0.28
Cerebellar Nuclei9.62 ± 0.34
Claustrum9.18 ± 0.3
Epithalamus9.93 ± 0.3
Frontal Lobe9.07 ± 0.42
Globus Pallidus10.04 ± 0.22
Hypothalamus9.04 ± 0.68
Insula9.1 ± 0.37
Limbic Lobe8.67 ± 0.43
Mesencephalon9.17 ± 0.4
Myelencephalon9.06 ± 0.43
Occipital Lobe8.93 ± 0.34
Parietal Lobe9.12 ± 0.4
Pontine Tegmentum9.14 ± 0.31
Striatum8.59 ± 0.63
Subthalamus9.18 ± 0.15
Temporal Lobe8.93 ± 0.34
Thalamus9.23 ± 0.29
White Matter10.24 ± 0.5
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00501753 22 886 907 VVKPLDVPAPSLEGDLGSTHWK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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