AutismKB 2.0

Annotation Detail for FN1


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Basic Information Top
Gene Symbol:FN1 ( CIG,DKFZp686F10164,DKFZp686H0342,DKFZp686I1370,DKFZp686O13149,ED-B,FINC,FN,FNZ,GFND,GFND2,LETS,MSF )
Gene Full Name: fibronectin 1
Band: 2q35
Quick LinksEntrez ID:2335; OMIM: 135600; Uniprot ID:FINC_HUMAN; ENSEMBL ID: ENSG00000115414; HGNC ID: 3778
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body427 / 707616034
blastocyst68 / 623191091
fetus285 / 564012505
neonate45 / 310971447
infant8 / 23620338
juvenile29 / 55556521
adult3477 / 19391211793
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor3 / 12794234
bladder carcinoma39 / 174752231
breast (mammary gland) tumor42 / 94178445
cervical tumor2 / 3436658
chondrosarcoma345 / 828234165
colorectal tumor70 / 114246612
esophageal tumor7 / 17290404
gastrointestinal tumor86 / 119369720
germ cell tumor50 / 263845189
glioma26 / 106883243
head and neck tumor192 / 1363021408
kidney tumor46 / 68959667
leukemia13 / 95842135
liver tumor106 / 963591100
lung tumor78 / 103127756
lymphoma13 / 71755181
non-neoplasia713 / 972507331
normal4607 / 33603071371
ovarian tumor43 / 76682560
pancreatic tumor95 / 104616908
primitive neuroectodermal tumor of the CNS9 / 12568071
prostate cancer3 / 10268029
retinoblastoma0 / 463560 
skin tumor17 / 124949136
soft tissue/muscle tissue tumor39 / 125191311
uterine tumor41 / 90257454
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue7 / 13106534
adrenal gland3 / 3319790
ascites0 / 400150 
bladder29 / 29757974
blood12 / 12347897
bone467 / 716556517
bone marrow246 / 488015040
brain406 / 1100989368
cervix2 / 4817141
connective tissue1081 / 1492557242
ear19 / 162121171
embryonic tissue556 / 2157222577
esophagus10 / 20209494
eye85 / 211054402
heart67 / 89626747
intestine168 / 234472716
kidney186 / 211777878
larynx54 / 241452236
liver201 / 207743967
lung471 / 3369741397
lymph1 / 4427022
lymph node4 / 9161043
mammary gland123 / 153271802
mouth80 / 670521193
muscle283 / 1077152627
nerve13 / 15768824
ovary23 / 102051225
pancreas117 / 214812544
parathyroid0 / 205390 
pharynx7 / 41328169
pituitary gland2 / 16585120
placenta1285 / 2808254575
prostate24 / 189345126
salivary gland3 / 20155148
skin273 / 2105741296
spleen2 / 5395237
stomach69 / 96619714
testis33 / 33044299
thymus53 / 81131653
thyroid59 / 474731242
tonsil1 / 1699958
trachea31 / 52413591
umbilical cord31 / 136802266
uterus95 / 232878407
vascular120 / 517802317
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 212464_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.45
Adipocyte9899.1
AdrenalCortex38.35
Adrenalgland116.8
Amygdala192.35
Appendix615.4
AtrioventricularNode330.1
BDCA4+_DentriticCells6.5
Bonemarrow7.6
BronchialEpithelialCells3174.6
CD105+_Endothelial36.4
CD14+_Monocytes8.2
CD19+_BCells(neg._sel.)6.4
CD33+_Myeloid9.75
CD34+5.8
CD4+_Tcells6.35
CD56+_NKCells5.05
CD71+_EarlyErythroid12.6
CD8+_Tcells4.05
CardiacMyocytes12044.35
Caudatenucleus76.75
Cerebellum55.15
CerebellumPeduncles42.55
CiliaryGanglion375.85
CingulateCortex35.15
Colorectaladenocarcinoma131.3
DorsalRootGanglion460.65
FetalThyroid348.05
Fetalbrain335.95
Fetalliver2242
Fetallung3248.55
GlobusPallidus17.35
Heart211.95
Hypothalamus197.4
Kidney83.65
Leukemia_chronicMyelogenousK-56210.65
Leukemia_promyelocytic-HL-607.45
Leukemialymphoblastic(MOLT-4)6.65
Liver5108.35
Lung3772.05
Lymphnode153.95
Lymphoma_burkitts(Daudi)7.85
Lymphoma_burkitts(Raji)12.95
MedullaOblongata35.2
OccipitalLobe153.05
OlfactoryBulb2778.8
Ovary165.35
Pancreas949.15
PancreaticIslet68.45
ParietalLobe43.1
Pituitary343.65
Placenta8714
Pons34.25
PrefrontalCortex211.1
Prostate698.35
Salivarygland44.5
SkeletalMuscle16.1
Skin51.25
SmoothMuscle12713.4
Spinalcord447.4
SubthalamicNucleus39.75
SuperiorCervicalGanglion408.5
TemporalLobe33.3
Testis92.3
TestisGermCell292.55
TestisIntersitial104.4
TestisLeydigCell198.15
TestisSeminiferousTubule56.8
Thalamus61.35
Thymus1131.55
Thyroid280.15
Tongue429.45
Tonsil54.6
Trachea852
TrigeminalGanglion445.4
Uterus1409
UterusCorpus353.55
WholeBlood9.9
Wholebrain72.6
colon1870
pineal_day42.56
pineal_night92.6
retina271.325
small_intestine689.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_14240_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.84 ± 0.49
Basal Forebrain5.72 ± 0.35
Basal Part of Pons5.34 ± 0.4
Cerebellar Cortex5.22 ± 0.32
Cerebellar Nuclei6.44 ± 0.46
Claustrum6.15 ± 0.54
Epithalamus5.49 ± 0.49
Frontal Lobe5.68 ± 0.57
Globus Pallidus7.18 ± 0.46
Hypothalamus5.37 ± 0.58
Insula5.51 ± 0.48
Limbic Lobe5.86 ± 0.73
Mesencephalon5.95 ± 0.5
Myelencephalon5.91 ± 0.59
Occipital Lobe5.82 ± 0.55
Parietal Lobe5.71 ± 0.63
Pontine Tegmentum5.96 ± 0.64
Striatum6.7 ± 0.65
Subthalamus5.87 ± 0.49
Temporal Lobe5.61 ± 0.51
Thalamus5.89 ± 0.49
White Matter6.79 ± 0.36
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Fn1CBCerebellum20.19
30.96
Fn1CTXCerebral cortex18.85
18.97
Fn1HIPHippocampal region18.51
23.22
Fn1HPFHippocampal formation28.76
38.94
Fn1HYHypothalamus13.77
14.8
Fn1LSXLateral septal complex15.86
17.96
Fn1MBMidbrain13.9
19.52
Fn1MYMedulla18.34
24.78
Fn1OLFOlfactory bulb39.79
38.66
Fn1PPons17.48
22.71
Fn1PALPallidum13.15
15.44
Fn1RHPRetrohippocampal region47.07
62.68
Fn1sAMYStriatum-like amygdalar nuclei13.86
15.57
Fn1STRStriatum14.07
14.85
Fn1STRdStriatum dorsal region13.24
14.21
Fn1STRvStriatum ventral region17.05
15.38
Fn1THThalamus14.49
18.6
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
FINC_HUMAN_1040 14 1040 1053 QYNVGPSVSKYPLR PRIDE
FINC_HUMAN_1054 16 1054 1069 NLQPASEYTVSLVAIK PRIDE
FINC_HUMAN_1116 41 1116 1156 LGVRPSQGGEAPREVTSDSGSIVVSGLTPGVEYVYTIQVLR PRIDE
FINC_HUMAN_1117 13 1117 1129 LGVRPSQGGEAPR PRIDE
FINC_HUMAN_1197 10 1197 1206 STTPDITGYR PRIDE
FINC_HUMAN_1275 10 1275 1284 FTNIGPDTMR PRIDE
FINC_HUMAN_1284 17 1284 1300 VTWAPPPSIDLTNFLVR PRIDE
FINC_HUMAN_1524 15 1524 1538 GDSPASSKPISINYR PRIDE
FINC_HUMAN_1561 12 1561 1572 WLPSSSPVTGYR PRIDE
FINC_HUMAN_1636 13 1636 1648 GLAFTDVDVDSIK PRIDE
FINC_HUMAN_1767 21 1767 1787 EINLAPDSSSVVVSGLMVATK PRIDE
FINC_HUMAN_1847 13 1847 1859 DAVPANGQTPIQR PRIDE
FINC_HUMAN_1866 14 1866 1879 SYTITGLQPGTDYK PRIDE
FINC_HUMAN_1880 11 1880 1890 IYLYTLNDNAR PRIDE
FINC_HUMAN_1891 19 1891 1909 SSPVVIDASTAIDAPSNLR PRIDE
FINC_HUMAN_1910 17 1910 1926 FLATTPNSLLVSWQPPR PRIDE
FINC_HUMAN_1988 31 1988 2018 KKTDELPQLVTLPHPNLHGPEILDVPSTVQK PRIDE
FINC_HUMAN_2149 15 2149 2163 VPGTSTSATLTGLTR PRIDE
FINC_HUMAN_2230 14 2230 2243 LLCQCLGFGSGHFR PRIDE
FINC_HUMAN_2334 22 2334 2355 RPGGEPSPEGTTGQSYNQYSQR PRIDE
FINC_HUMAN_369 10 369 378 TFYSCTTEGR PRIDE
FINC_HUMAN_487 9 487 495 QHDMGHMMR PRIDE
FINC_HUMAN_669 25 669 693 GLKPGVVYEGQLISIQQYGHQEVTR PRIDE
FINC_HUMAN_830 12 830 841 WSRPQAPITGYR PRIDE
FINC_HUMAN_911 11 911 921 DLQFVEVTDVK PRIDE
FINC_HUMAN_922 31 922 952 VTIMWTPPESAVTGYRVDVIPVNLPGEHGQR PRIDE
FINC_HUMAN_938 20 938 957 VDVIPVNLPGEHGQRLPISR PRIDE
FINC_HUMAN_939 15 939 953 VDVIPVNLPGEHGQR PRIDE
FINC_HUMAN_958 18 958 975 NTFAEVTGLSPGVTYYFK PRIDE
PAp00000001 16 464 479 AAHEEICTTNEGVMYR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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