AutismKB 2.0

Annotation Detail for FAM189A1


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Basic Information Top
Gene Symbol:FAM189A1 ( FLJ61121,KIAA0574,TMEM228 )
Gene Full Name: family with sequence similarity 189, member A1
Band: 15q13.1
Quick LinksEntrez ID:23359; OMIM: NA; Uniprot ID:F1891_HUMAN; ENSEMBL ID: ENSG00000104059; HGNC ID: 29075
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus3 / 5640125
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult8 / 19391214
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor1 / 2638453
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal49 / 336030714
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain27 / 110098924
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye6 / 21105428
heart0 / 896260 
intestine0 / 2344720 
kidney3 / 21177714
larynx0 / 241450 
liver0 / 2077430 
lung0 / 3369740 
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis1 / 3304423
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus1 / 2328784
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 213997_at
Cell line Expression level Expression bar
721_B_lymphoblasts9.85
Adipocyte10.65
AdrenalCortex19.9
Adrenalgland11.15
Amygdala87.15
Appendix13.05
AtrioventricularNode32.8
BDCA4+_DentriticCells9
Bonemarrow15.9
BronchialEpithelialCells10.1
CD105+_Endothelial10.15
CD14+_Monocytes9.85
CD19+_BCells(neg._sel.)10.15
CD33+_Myeloid12.4
CD34+10.65
CD4+_Tcells9.4
CD56+_NKCells11.3
CD71+_EarlyErythroid9.85
CD8+_Tcells7.9
CardiacMyocytes17.85
Caudatenucleus22.1
Cerebellum22.8
CerebellumPeduncles31.15
CiliaryGanglion9.1
CingulateCortex81.25
Colorectaladenocarcinoma10.75
DorsalRootGanglion16.8
FetalThyroid12.35
Fetalbrain74.95
Fetalliver8.95
Fetallung7.7
GlobusPallidus34.2
Heart23.35
Hypothalamus22.2
Kidney19.55
Leukemia_chronicMyelogenousK-56210.9
Leukemia_promyelocytic-HL-6017.35
Leukemialymphoblastic(MOLT-4)8.25
Liver22.45
Lung13.55
Lymphnode9.2
Lymphoma_burkitts(Daudi)14.5
Lymphoma_burkitts(Raji)17.6
MedullaOblongata44.3
OccipitalLobe48.25
OlfactoryBulb8.4
Ovary8.75
Pancreas8.85
PancreaticIslet13.45
ParietalLobe30.35
Pituitary15.5
Placenta10.75
Pons17.8
PrefrontalCortex32.2
Prostate11.65
Salivarygland10.45
SkeletalMuscle16.7
Skin9.6
SmoothMuscle11.9
Spinalcord16.95
SubthalamicNucleus56.5
SuperiorCervicalGanglion17.8
TemporalLobe33.75
Testis17.1
TestisGermCell10.75
TestisIntersitial9.35
TestisLeydigCell12.7
TestisSeminiferousTubule14.45
Thalamus69.25
Thymus7.6
Thyroid13.35
Tongue20.8
Tonsil11.5
Trachea8.65
TrigeminalGanglion32
Uterus8.65
UterusCorpus12.8
WholeBlood11
Wholebrain49.35
colon16.5
pineal_day13.88
pineal_night12.18
retina12.425
small_intestine13.05
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P143000
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.85 ± 0.66
Basal Forebrain7.71 ± 0.36
Basal Part of Pons8.88 ± 0.38
Cerebellar Cortex7.62 ± 0.25
Cerebellar Nuclei7.32 ± 0.8
Claustrum7.49 ± 0.54
Epithalamus6.8 ± 0.86
Frontal Lobe8.38 ± 0.53
Globus Pallidus6.37 ± 1.09
Hypothalamus7.22 ± 0.53
Insula8.66 ± 0.36
Limbic Lobe8.77 ± 0.54
Mesencephalon7.7 ± 0.7
Myelencephalon8.08 ± 0.73
Occipital Lobe8.44 ± 0.89
Parietal Lobe8.14 ± 0.58
Pontine Tegmentum7.69 ± 0.56
Striatum8.69 ± 0.57
Subthalamus6.88 ± 0.11
Temporal Lobe8.13 ± 0.56
Thalamus8.34 ± 0.5
White Matter5.31 ± 0.71
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
5730507A09RikCBCerebellum13.68
15.62
5730507A09RikCTXCerebral cortex78.66
69.36
5730507A09RikHIPHippocampal region59.14
100
5730507A09RikHPFHippocampal formation67.8
93.15
5730507A09RikHYHypothalamus8.23
6.16
5730507A09RikLSXLateral septal complex35.02
26.93
5730507A09RikMBMidbrain7.98
7.84
5730507A09RikMYMedulla20.61
22.39
5730507A09RikOLFOlfactory bulb52.04
53.2
5730507A09RikPPons12.87
13.41
5730507A09RikPALPallidum18.16
16.82
5730507A09RikRHPRetrohippocampal region82.09
84.42
5730507A09RiksAMYStriatum-like amygdalar nuclei26.88
20.91
5730507A09RikSTRStriatum19.51
14.35
5730507A09RikSTRdStriatum dorsal region17.11
12.38
5730507A09RikSTRvStriatum ventral region19.76
14.11
5730507A09RikTHThalamus19.71
17.38
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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