AutismKB 2.0

Annotation Detail for PUM2


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Basic Information Top
Gene Symbol:PUM2 ( FLJ36528,KIAA0235,MGC138251,MGC138253,PUMH2,PUML2 )
Gene Full Name: pumilio homolog 2 (Drosophila)
Band: 2p24.1
Quick LinksEntrez ID:23369; OMIM: 607205; Uniprot ID:PUM2_HUMAN; ENSEMBL ID: ENSG00000055917; HGNC ID: 14958
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst11 / 62319176
fetus29 / 56401251
neonate1 / 3109732
infant0 / 236200 
juvenile2 / 5555635
adult139 / 193912171
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma5 / 17475286
breast (mammary gland) tumor21 / 94178222
cervical tumor2 / 3436658
chondrosarcoma2 / 8282324
colorectal tumor14 / 114246122
esophageal tumor1 / 1729057
gastrointestinal tumor10 / 11936983
germ cell tumor16 / 26384560
glioma1 / 1068839
head and neck tumor15 / 136302110
kidney tumor3 / 6895943
leukemia5 / 9584252
liver tumor7 / 9635972
lung tumor4 / 10312738
lymphoma5 / 7175569
non-neoplasia3 / 9725030
normal248 / 336030773
ovarian tumor8 / 76682104
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer2 / 10268019
retinoblastoma3 / 4635664
skin tumor9 / 12494972
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor10 / 90257110
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland3 / 3319790
ascites1 / 4001524
bladder3 / 29757100
blood7 / 12347856
bone2 / 7165527
bone marrow1 / 4880120
brain61 / 110098955
cervix3 / 4817162
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue22 / 215722101
esophagus1 / 2020949
eye18 / 21105485
heart3 / 8962633
intestine21 / 23447289
kidney20 / 21177794
larynx1 / 2414541
liver13 / 20774362
lung11 / 33697432
lymph2 / 4427045
lymph node26 / 91610283
mammary gland28 / 153271182
mouth10 / 67052149
muscle9 / 10771583
nerve0 / 157680 
ovary9 / 10205188
pancreas6 / 21481227
parathyroid0 / 205390 
pharynx3 / 4132872
pituitary gland0 / 165850 
placenta17 / 28082560
prostate7 / 18934536
salivary gland0 / 201550 
skin16 / 21057475
spleen0 / 539520 
stomach7 / 9661972
testis16 / 33044248
thymus9 / 81131110
thyroid5 / 47473105
tonsil0 / 169990 
trachea13 / 52413248
umbilical cord0 / 136800 
uterus18 / 23287877
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201493_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts449.6
Adipocyte27.45
AdrenalCortex26.3
Adrenalgland19.45
Amygdala130.3
Appendix25.55
AtrioventricularNode19.15
BDCA4+_DentriticCells205.2
Bonemarrow39.3
BronchialEpithelialCells36.85
CD105+_Endothelial100.3
CD14+_Monocytes155.6
CD19+_BCells(neg._sel.)251.75
CD33+_Myeloid221.7
CD34+409.2
CD4+_Tcells469.95
CD56+_NKCells397.2
CD71+_EarlyErythroid156.05
CD8+_Tcells525.85
CardiacMyocytes27.5
Caudatenucleus25.75
Cerebellum51.25
CerebellumPeduncles47.8
CiliaryGanglion13.75
CingulateCortex47.05
Colorectaladenocarcinoma71.1
DorsalRootGanglion16.05
FetalThyroid32.6
Fetalbrain119.45
Fetalliver82.75
Fetallung108.45
GlobusPallidus18.85
Heart21.9
Hypothalamus54.2
Kidney18
Leukemia_chronicMyelogenousK-56248.9
Leukemia_promyelocytic-HL-6079.5
Leukemialymphoblastic(MOLT-4)159.6
Liver25.6
Lung21.8
Lymphnode89.15
Lymphoma_burkitts(Daudi)110.45
Lymphoma_burkitts(Raji)55.25
MedullaOblongata39.4
OccipitalLobe105.3
OlfactoryBulb45.75
Ovary34.75
Pancreas72.95
PancreaticIslet57.95
ParietalLobe25.2
Pituitary96
Placenta182.45
Pons22.2
PrefrontalCortex114.25
Prostate62.15
Salivarygland52.15
SkeletalMuscle29.4
Skin21.4
SmoothMuscle50.7
Spinalcord57.15
SubthalamicNucleus19.65
SuperiorCervicalGanglion62.35
TemporalLobe26.8
Testis18.2
TestisGermCell59.4
TestisIntersitial19.65
TestisLeydigCell34.75
TestisSeminiferousTubule25.25
Thalamus45.25
Thymus75.3
Thyroid201.2
Tongue28.2
Tonsil94.5
Trachea98.9
TrigeminalGanglion38.9
Uterus121.1
UterusCorpus21.1
WholeBlood240.85
Wholebrain35.55
colon85.15
pineal_day390.34
pineal_night349.92
retina121.6
small_intestine61.45
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P71439
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.8 ± 0.12
Basal Forebrain9.68 ± 0.09
Basal Part of Pons9.43 ± 0.14
Cerebellar Cortex9.66 ± 0.23
Cerebellar Nuclei9.45 ± 0.23
Claustrum9.71 ± 0.23
Epithalamus9.68 ± 0.15
Frontal Lobe9.56 ± 0.24
Globus Pallidus9.41 ± 0.1
Hypothalamus9.51 ± 0.18
Insula9.55 ± 0.22
Limbic Lobe9.82 ± 0.22
Mesencephalon9.59 ± 0.17
Myelencephalon9.59 ± 0.22
Occipital Lobe9.84 ± 0.16
Parietal Lobe9.73 ± 0.21
Pontine Tegmentum9.64 ± 0.19
Striatum9.51 ± 0.2
Subthalamus9.38 ± 0.27
Temporal Lobe9.65 ± 0.21
Thalamus9.5 ± 0.18
White Matter9.91 ± 0.25
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Pum2CBCerebellum100
100
Pum2CTXCerebral cortex100
100
Pum2HIPHippocampal region89.53
100
Pum2HPFHippocampal formation95.52
100
Pum2HYHypothalamus58.1
48.29
Pum2LSXLateral septal complex87.87
72.7
Pum2MBMidbrain45.25
39.03
Pum2MYMedulla32.39
31.21
Pum2OLFOlfactory bulb100
100
Pum2PPons26.63
25.73
Pum2PALPallidum49.88
47.31
Pum2RHPRetrohippocampal region100
97.41
Pum2sAMYStriatum-like amygdalar nuclei91.02
76.22
Pum2STRStriatum94.88
78.63
Pum2STRdStriatum dorsal region95.76
77.38
Pum2STRvStriatum ventral region99.31
84.7
Pum2THThalamus62.67
59.52
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00010220 14 801 814 GHVLPLALQMYGCR Peptide Atlas
PUM2_HUMAN_1 13 1 13 MNHDFQALALESR PRIDE
PUM2_HUMAN_77 8 77 84 VNAILSPR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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