AutismKB 2.0

Annotation Detail for CRTC1


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Basic Information Top
Gene Symbol:CRTC1 ( FLJ14027,KIAA0616,MECT1,TORC1,WAMTP1 )
Gene Full Name: CREB regulated transcription coactivator 1
Band: 19p13.11
Quick LinksEntrez ID:23373; OMIM: 607536; Uniprot ID:CRTC1_HUMAN; ENSEMBL ID: ENSG00000105662; HGNC ID: 16062
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst2 / 6231932
fetus40 / 56401270
neonate2 / 3109764
infant3 / 23620127
juvenile1 / 5555617
adult75 / 193912138
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor4 / 9417842
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor5 / 11424643
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor10 / 26384537
glioma8 / 10688374
head and neck tumor1 / 1363027
kidney tumor1 / 6895914
leukemia5 / 9584252
liver tumor1 / 9635910
lung tumor1 / 1031279
lymphoma1 / 7175513
non-neoplasia0 / 972500 
normal266 / 336030779
ovarian tumor2 / 7668226
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer0 / 1026800 
retinoblastoma1 / 4635621
skin tumor1 / 1249498
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites1 / 4001524
bladder0 / 297570 
blood5 / 12347840
bone1 / 7165513
bone marrow0 / 488010 
brain173 / 1100989157
cervix0 / 481710 
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue14 / 21572264
esophagus0 / 202090 
eye13 / 21105461
heart2 / 8962622
intestine8 / 23447234
kidney3 / 21177714
larynx0 / 241450 
liver2 / 2077439
lung6 / 33697417
lymph1 / 4427022
lymph node5 / 9161054
mammary gland4 / 15327126
mouth0 / 670520 
muscle0 / 1077150 
nerve2 / 15768126
ovary1 / 1020519
pancreas26 / 214812121
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta12 / 28082542
prostate2 / 18934510
salivary gland0 / 201550 
skin1 / 2105744
spleen1 / 5395218
stomach0 / 966190 
testis8 / 33044224
thymus1 / 8113112
thyroid1 / 4747321
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord2 / 13680146
uterus4 / 23287817
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 207159_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.3
Adipocyte5.35
AdrenalCortex5.7
Adrenalgland4.5
Amygdala6.15
Appendix5.35
AtrioventricularNode3.95
BDCA4+_DentriticCells5.6
Bonemarrow5.3
BronchialEpithelialCells5.2
CD105+_Endothelial5.4
CD14+_Monocytes5.75
CD19+_BCells(neg._sel.)6.05
CD33+_Myeloid6.75
CD34+6.85
CD4+_Tcells6
CD56+_NKCells6.5
CD71+_EarlyErythroid5
CD8+_Tcells5.25
CardiacMyocytes7.45
Caudatenucleus4.8
Cerebellum4.4
CerebellumPeduncles6.1
CiliaryGanglion3.65
CingulateCortex5.5
Colorectaladenocarcinoma5.35
DorsalRootGanglion3.95
FetalThyroid5.2
Fetalbrain5.45
Fetalliver4.6
Fetallung5.1
GlobusPallidus3.85
Heart6.7
Hypothalamus6
Kidney4.25
Leukemia_chronicMyelogenousK-5627.35
Leukemia_promyelocytic-HL-605.1
Leukemialymphoblastic(MOLT-4)4.4
Liver7.35
Lung6.05
Lymphnode4.7
Lymphoma_burkitts(Daudi)7
Lymphoma_burkitts(Raji)7.5
MedullaOblongata5
OccipitalLobe4.75
OlfactoryBulb4.2
Ovary3.55
Pancreas4.3
PancreaticIslet5.7
ParietalLobe5.7
Pituitary6.25
Placenta5.5
Pons5.1
PrefrontalCortex7.9
Prostate6.4
Salivarygland4.3
SkeletalMuscle6.3
Skin4.1
SmoothMuscle6.1
Spinalcord9.35
SubthalamicNucleus4.8
SuperiorCervicalGanglion6.1
TemporalLobe4.95
Testis4.65
TestisGermCell4.55
TestisIntersitial4.55
TestisLeydigCell5.3
TestisSeminiferousTubule4.45
Thalamus5.5
Thymus4.1
Thyroid6.55
Tongue5.3
Tonsil5.2
Trachea4.45
TrigeminalGanglion5.4
Uterus4.4
UterusCorpus6.25
WholeBlood5.9
Wholebrain5.3
colon5.4
pineal_day7.2
pineal_night11.24
retina6.575
small_intestine5.05
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P50773
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala16.05 ± 0.49
Basal Forebrain15.82 ± 0.09
Basal Part of Pons16.18 ± 0.18
Cerebellar Cortex15.68 ± 0.24
Cerebellar Nuclei16.03 ± 0.26
Claustrum16.08 ± 0.35
Epithalamus15.65 ± 0.1
Frontal Lobe15.94 ± 0.37
Globus Pallidus16.45 ± 0.26
Hypothalamus15.86 ± 0.44
Insula15.88 ± 0.31
Limbic Lobe16.03 ± 0.38
Mesencephalon15.91 ± 0.34
Myelencephalon15.98 ± 0.4
Occipital Lobe15.91 ± 0.34
Parietal Lobe15.84 ± 0.33
Pontine Tegmentum15.81 ± 0.4
Striatum16.21 ± 0.32
Subthalamus15.85 ± 0.17
Temporal Lobe15.93 ± 0.35
Thalamus15.99 ± 0.34
White Matter16.49 ± 0.06
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Crtc1CBCerebellum68.23
88.26
Crtc1CTXCerebral cortex99.38
82.08
Crtc1HIPHippocampal region99.33
100
Crtc1HPFHippocampal formation88.14
100
Crtc1HYHypothalamus31.2
24.34
Crtc1LSXLateral septal complex50.51
37.25
Crtc1MBMidbrain31.65
26.99
Crtc1MYMedulla34.97
36.29
Crtc1OLFOlfactory bulb83.6
77.77
Crtc1PPons26.04
24.91
Crtc1PALPallidum33.11
27.58
Crtc1RHPRetrohippocampal region72.1
60.84
Crtc1sAMYStriatum-like amygdalar nuclei83.95
65.88
Crtc1STRStriatum84.29
63.63
Crtc1STRdStriatum dorsal region88.46
66.45
Crtc1STRvStriatum ventral region86.93
64.97
Crtc1THThalamus30.13
24.4
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
CRTC1_HUMAN_21 13 21 33 QAEETAAFEEVMK PRIDE
CRTC1_HUMAN_602 29 602 630 IDPLTLDGLHMLNDPDMVLADPATEDTFR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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