AutismKB 2.0

Annotation Detail for SRGAP2


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Basic Information Top
Gene Symbol:SRGAP2 ( ARHGAP34,FNBP2,KIAA0456,SRGAP3 )
Gene Full Name: SLIT-ROBO Rho GTPase activating protein 2
Band: 1q32.1
Quick LinksEntrez ID:23380; OMIM: 606524; Uniprot ID:FNBP2_HUMAN; ENSEMBL ID: ENSG00000163486; HGNC ID: 19751
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body9 / 70761127
blastocyst2 / 6231932
fetus47 / 56401283
neonate1 / 3109732
infant0 / 236200 
juvenile1 / 5555617
adult72 / 193912137
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor3 / 12794234
bladder carcinoma1 / 1747557
breast (mammary gland) tumor1 / 9417810
cervical tumor1 / 3436629
chondrosarcoma7 / 8282384
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor3 / 11936925
germ cell tumor17 / 26384564
glioma12 / 106883112
head and neck tumor3 / 13630222
kidney tumor2 / 6895929
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor4 / 10312738
lymphoma0 / 717550 
non-neoplasia5 / 9725051
normal196 / 336030758
ovarian tumor9 / 76682117
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer1 / 1026809
retinoblastoma6 / 46356129
skin tumor12 / 12494996
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland4 / 33197120
ascites1 / 4001524
bladder0 / 297570 
blood2 / 12347816
bone4 / 7165555
bone marrow0 / 488010 
brain101 / 110098991
cervix4 / 4817183
connective tissue8 / 14925553
ear1 / 1621261
embryonic tissue15 / 21572269
esophagus0 / 202090 
eye17 / 21105480
heart3 / 8962633
intestine5 / 23447221
kidney4 / 21177718
larynx1 / 2414541
liver2 / 2077439
lung14 / 33697441
lymph0 / 442700 
lymph node13 / 91610141
mammary gland3 / 15327119
mouth1 / 6705214
muscle5 / 10771546
nerve1 / 1576863
ovary10 / 10205197
pancreas2 / 2148129
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta9 / 28082532
prostate2 / 18934510
salivary gland0 / 201550 
skin22 / 210574104
spleen3 / 5395255
stomach1 / 9661910
testis9 / 33044227
thymus4 / 8113149
thyroid1 / 4747321
tonsil1 / 1699958
trachea0 / 524130 
umbilical cord1 / 1368073
uterus8 / 23287834
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 213329_at
Cell line Expression level Expression bar
721_B_lymphoblasts4.8
Adipocyte3.9
AdrenalCortex5.3
Adrenalgland3.3
Amygdala5.95
Appendix3.85
AtrioventricularNode2.95
BDCA4+_DentriticCells14.15
Bonemarrow3.85
BronchialEpithelialCells3.85
CD105+_Endothelial5.3
CD14+_Monocytes4.75
CD19+_BCells(neg._sel.)4.2
CD33+_Myeloid26.45
CD34+7.4
CD4+_Tcells4.25
CD56+_NKCells4.75
CD71+_EarlyErythroid4.65
CD8+_Tcells3.85
CardiacMyocytes5.35
Caudatenucleus3.5
Cerebellum45.1
CerebellumPeduncles58.8
CiliaryGanglion2.7
CingulateCortex4.05
Colorectaladenocarcinoma56.3
DorsalRootGanglion2.95
FetalThyroid3.8
Fetalbrain27.3
Fetalliver3.3
Fetallung3.3
GlobusPallidus2.9
Heart4.9
Hypothalamus5.25
Kidney3.1
Leukemia_chronicMyelogenousK-5624.5
Leukemia_promyelocytic-HL-603.5
Leukemialymphoblastic(MOLT-4)3.15
Liver5.15
Lung4.35
Lymphnode3.4
Lymphoma_burkitts(Daudi)5
Lymphoma_burkitts(Raji)5.4
MedullaOblongata3.65
OccipitalLobe4.25
OlfactoryBulb3.9
Ovary2.6
Pancreas3.15
PancreaticIslet4.2
ParietalLobe4.15
Pituitary4.6
Placenta7.3
Pons3.8
PrefrontalCortex5.15
Prostate4.6
Salivarygland3.1
SkeletalMuscle4.4
Skin3.05
SmoothMuscle4.5
Spinalcord8.15
SubthalamicNucleus3.6
SuperiorCervicalGanglion4.35
TemporalLobe4.5
Testis3.35
TestisGermCell3.3
TestisIntersitial3.3
TestisLeydigCell3.85
TestisSeminiferousTubule3.4
Thalamus4.25
Thymus3.15
Thyroid4.9
Tongue3.75
Tonsil3.8
Trachea3.3
TrigeminalGanglion3.8
Uterus3.3
UterusCorpus3.45
WholeBlood4.3
Wholebrain5.1
colon3.9
pineal_day4.9
pineal_night4.82
retina4.775
small_intestine3.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P50123
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.21 ± 0.38
Basal Forebrain6.73 ± 0.31
Basal Part of Pons7.47 ± 0.18
Cerebellar Cortex7.52 ± 0.26
Cerebellar Nuclei7.35 ± 0.33
Claustrum7.13 ± 0.48
Epithalamus7.2 ± 0.34
Frontal Lobe6.8 ± 0.44
Globus Pallidus7.21 ± 0.54
Hypothalamus6.53 ± 0.56
Insula6.83 ± 0.28
Limbic Lobe7.2 ± 0.42
Mesencephalon6.83 ± 0.35
Myelencephalon6.97 ± 0.39
Occipital Lobe7.15 ± 0.4
Parietal Lobe6.89 ± 0.5
Pontine Tegmentum6.81 ± 0.54
Striatum6.84 ± 0.5
Subthalamus7 ± 0.3
Temporal Lobe6.9 ± 0.36
Thalamus6.75 ± 0.39
White Matter8.1 ± 0.47
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00079206 19 972 990 TNATSPGVNSSTSPQSTDK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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