AutismKB 2.0

Annotation Detail for SIK3


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Basic Information Top
Gene Symbol:SIK3 ( FLJ12240,KIAA0999,QSK )
Gene Full Name: SIK family kinase 3
Band: 11q23.3
Quick LinksEntrez ID:23387; OMIM: NA; Uniprot ID:SIK3_HUMAN; ENSEMBL ID: ENSG00000160584; HGNC ID: 29165
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst2 / 6231932
fetus37 / 56401265
neonate0 / 310970 
infant2 / 2362084
juvenile1 / 5555617
adult126 / 193912164
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma5 / 8282360
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor3 / 11936925
germ cell tumor1 / 2638453
glioma6 / 10688356
head and neck tumor13 / 13630295
kidney tumor5 / 6895972
leukemia1 / 9584210
liver tumor0 / 963590 
lung tumor23 / 103127223
lymphoma1 / 7175513
non-neoplasia0 / 972500 
normal159 / 336030747
ovarian tumor0 / 766820 
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer0 / 1026800 
retinoblastoma1 / 4635621
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor6 / 12519147
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood2 / 12347816
bone3 / 7165541
bone marrow0 / 488010 
brain39 / 110098935
cervix0 / 481710 
connective tissue4 / 14925526
ear0 / 162120 
embryonic tissue5 / 21572223
esophagus0 / 202090 
eye13 / 21105461
heart1 / 8962611
intestine6 / 23447225
kidney14 / 21177766
larynx9 / 24145372
liver1 / 2077434
lung40 / 336974118
lymph0 / 442700 
lymph node2 / 9161021
mammary gland5 / 15327132
mouth3 / 6705244
muscle3 / 10771527
nerve2 / 15768126
ovary0 / 1020510 
pancreas15 / 21481269
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta10 / 28082535
prostate4 / 18934521
salivary gland0 / 201550 
skin2 / 2105749
spleen1 / 5395218
stomach1 / 9661910
testis22 / 33044266
thymus0 / 811310 
thyroid1 / 4747321
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus11 / 23287847
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204157_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts19.5
Adipocyte7.95
AdrenalCortex9.4
Adrenalgland8.4
Amygdala13.4
Appendix10.6
AtrioventricularNode7.3
BDCA4+_DentriticCells23.9
Bonemarrow9.7
BronchialEpithelialCells7.85
CD105+_Endothelial9.1
CD14+_Monocytes28.5
CD19+_BCells(neg._sel.)22.75
CD33+_Myeloid74.45
CD34+13.4
CD4+_Tcells15.15
CD56+_NKCells22.1
CD71+_EarlyErythroid25.65
CD8+_Tcells14.45
CardiacMyocytes11.45
Caudatenucleus8.6
Cerebellum18
CerebellumPeduncles9.9
CiliaryGanglion6.7
CingulateCortex10.4
Colorectaladenocarcinoma8.7
DorsalRootGanglion7.55
FetalThyroid8.15
Fetalbrain7.5
Fetalliver7.85
Fetallung7.35
GlobusPallidus6.6
Heart12
Hypothalamus10.9
Kidney7.45
Leukemia_chronicMyelogenousK-5627.55
Leukemia_promyelocytic-HL-608.15
Leukemialymphoblastic(MOLT-4)6.25
Liver13.8
Lung9.4
Lymphnode6.6
Lymphoma_burkitts(Daudi)11.15
Lymphoma_burkitts(Raji)12.55
MedullaOblongata9.85
OccipitalLobe8.1
OlfactoryBulb6.3
Ovary5.95
Pancreas6.8
PancreaticIslet9.45
ParietalLobe9.55
Pituitary9.65
Placenta31.9
Pons8.6
PrefrontalCortex11.25
Prostate9.15
Salivarygland7.15
SkeletalMuscle13.85
Skin7.5
SmoothMuscle9.15
Spinalcord8.8
SubthalamicNucleus7.8
SuperiorCervicalGanglion10.9
TemporalLobe7.95
Testis272.65
TestisGermCell168.6
TestisIntersitial209.15
TestisLeydigCell105.5
TestisSeminiferousTubule71.65
Thalamus9.05
Thymus9.15
Thyroid11.05
Tongue8.8
Tonsil8.5
Trachea6.8
TrigeminalGanglion10.2
Uterus6.25
UterusCorpus16.95
WholeBlood23.5
Wholebrain10.95
colon8.15
pineal_day13.12
pineal_night10.86
retina10.775
small_intestine8.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P347067
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.15 ± 0.34
Basal Forebrain8.38 ± 0.23
Basal Part of Pons8.52 ± 0.35
Cerebellar Cortex7.93 ± 0.17
Cerebellar Nuclei8.55 ± 0.16
Claustrum7.95 ± 0.32
Epithalamus7.9 ± 0.3
Frontal Lobe8.11 ± 0.3
Globus Pallidus8.52 ± 0.2
Hypothalamus7.98 ± 0.36
Insula8.03 ± 0.2
Limbic Lobe8.2 ± 0.36
Mesencephalon8.3 ± 0.3
Myelencephalon8.26 ± 0.37
Occipital Lobe8.76 ± 0.45
Parietal Lobe8.29 ± 0.25
Pontine Tegmentum8.31 ± 0.47
Striatum9.29 ± 0.47
Subthalamus8.01 ± 0.36
Temporal Lobe8.13 ± 0.25
Thalamus8.57 ± 0.27
White Matter9.34 ± 0.23
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
BC033915CBCerebellum17.38
21.38
BC033915CTXCerebral cortex39.88
29.94
BC033915HIPHippocampal region22.92
26.1
BC033915HPFHippocampal formation31.47
30.22
BC033915HYHypothalamus28.85
22.27
BC033915LSXLateral septal complex38.83
25.88
BC033915MBMidbrain36.97
31.94
BC033915MYMedulla45.18
46.06
BC033915OLFOlfactory bulb42.72
33.07
BC033915PPons41.38
39.32
BC033915PALPallidum29.91
24.43
BC033915RHPRetrohippocampal region47.35
38.17
BC033915sAMYStriatum-like amygdalar nuclei33.27
22.47
BC033915STRStriatum47.67
31.37
BC033915STRdStriatum dorsal region49
32.46
BC033915STRvStriatum ventral region55.37
34.44
BC033915THThalamus59.24
48.38
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp01420416 8 584 591 MGNNSSIK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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