AutismKB 2.0

Annotation Detail for LARS2


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Basic Information Top
Gene Symbol:LARS2 ( KIAA0028,LEURS,MGC26121 )
Gene Full Name: leucyl-tRNA synthetase 2, mitochondrial
Band: 3p21.31
Quick LinksEntrez ID:23395; OMIM: 604544; Uniprot ID:SYLM_HUMAN; ENSEMBL ID: ENSG00000011376; HGNC ID: 17095
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst8 / 62319128
fetus18 / 56401231
neonate4 / 31097128
infant0 / 236200 
juvenile2 / 5555635
adult79 / 193912140
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor4 / 9417842
cervical tumor2 / 3436658
chondrosarcoma1 / 8282312
colorectal tumor8 / 11424670
esophageal tumor0 / 172900 
gastrointestinal tumor4 / 11936933
germ cell tumor22 / 26384583
glioma0 / 1068830 
head and neck tumor6 / 13630244
kidney tumor2 / 6895929
leukemia8 / 9584283
liver tumor17 / 96359176
lung tumor5 / 10312748
lymphoma5 / 7175569
non-neoplasia1 / 9725010
normal150 / 336030744
ovarian tumor3 / 7668239
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer4 / 10268038
retinoblastoma2 / 4635643
skin tumor6 / 12494948
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder1 / 2975733
blood6 / 12347848
bone2 / 7165527
bone marrow2 / 4880140
brain83 / 110098975
cervix3 / 4817162
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue13 / 21572260
esophagus0 / 202090 
eye6 / 21105428
heart2 / 8962622
intestine17 / 23447272
kidney6 / 21177728
larynx0 / 241450 
liver17 / 20774381
lung12 / 33697435
lymph0 / 442700 
lymph node0 / 916100 
mammary gland9 / 15327158
mouth5 / 6705274
muscle1 / 1077159
nerve0 / 157680 
ovary3 / 10205129
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta8 / 28082528
prostate9 / 18934547
salivary gland0 / 201550 
skin9 / 21057442
spleen1 / 5395218
stomach3 / 9661931
testis37 / 330442111
thymus3 / 8113136
thyroid1 / 4747321
tonsil2 / 16999117
trachea15 / 52413286
umbilical cord3 / 13680219
uterus8 / 23287834
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 34764_at
Cell line Expression level Expression bar
721_B_lymphoblasts69.3
Adipocyte12.35
AdrenalCortex14.05
Adrenalgland13.9
Amygdala22.05
Appendix15.35
AtrioventricularNode10.95
BDCA4+_DentriticCells15.65
Bonemarrow14.9
BronchialEpithelialCells30.5
CD105+_Endothelial27.75
CD14+_Monocytes11.6
CD19+_BCells(neg._sel.)12.75
CD33+_Myeloid14.25
CD34+19.05
CD4+_Tcells11.6
CD56+_NKCells14.1
CD71+_EarlyErythroid11.7
CD8+_Tcells10.9
CardiacMyocytes19.2
Caudatenucleus16.3
Cerebellum11.1
CerebellumPeduncles14.7
CiliaryGanglion9.8
CingulateCortex14.35
Colorectaladenocarcinoma19.6
DorsalRootGanglion10
FetalThyroid11.9
Fetalbrain14.1
Fetalliver12.5
Fetallung10.2
GlobusPallidus9.8
Heart25.45
Hypothalamus19.4
Kidney13.25
Leukemia_chronicMyelogenousK-56222.65
Leukemia_promyelocytic-HL-6047.15
Leukemialymphoblastic(MOLT-4)10
Liver25.9
Lung37.35
Lymphnode10.1
Lymphoma_burkitts(Daudi)19.55
Lymphoma_burkitts(Raji)47.8
MedullaOblongata13.25
OccipitalLobe20.75
OlfactoryBulb9.8
Ovary8.05
Pancreas10.15
PancreaticIslet13.35
ParietalLobe18.6
Pituitary14.85
Placenta13.25
Pons18.9
PrefrontalCortex19.9
Prostate26.3
Salivarygland10.95
SkeletalMuscle18.45
Skin10.4
SmoothMuscle18.45
Spinalcord14.9
SubthalamicNucleus11.9
SuperiorCervicalGanglion27.95
TemporalLobe12.55
Testis11.1
TestisGermCell9.4
TestisIntersitial9.8
TestisLeydigCell11.9
TestisSeminiferousTubule9.8
Thalamus17.25
Thymus18.35
Thyroid22.25
Tongue13.1
Tonsil11.75
Trachea9.75
TrigeminalGanglion13.8
Uterus13.45
UterusCorpus11.65
WholeBlood12.7
Wholebrain45.95
colon40.85
pineal_day19.36
pineal_night20.12
retina14.475
small_intestine23.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_9112_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.83 ± 0.94
Basal Forebrain2.1 ± 0.47
Basal Part of Pons2.07 ± 0.31
Cerebellar Cortex2.5 ± 0.62
Cerebellar Nuclei2.59 ± 0.86
Claustrum2.83 ± 0.73
Epithalamus2.59 ± 0.61
Frontal Lobe2.32 ± 0.65
Globus Pallidus2.62 ± 0.57
Hypothalamus2.27 ± 0.89
Insula2.18 ± 0.58
Limbic Lobe2.51 ± 0.65
Mesencephalon2.63 ± 0.76
Myelencephalon2.47 ± 0.68
Occipital Lobe2.69 ± 0.76
Parietal Lobe2.36 ± 0.67
Pontine Tegmentum2.57 ± 0.71
Striatum2.94 ± 0.7
Subthalamus2.46 ± 0.72
Temporal Lobe2.39 ± 0.73
Thalamus2.6 ± 0.63
White Matter2.51 ± 0.36
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Lars2CBCerebellum2.37
2.35
Lars2CTXCerebral cortex2.96
2.43
Lars2HIPHippocampal region3.28
3.61
Lars2HPFHippocampal formation2.9
2.82
Lars2HYHypothalamus1.74
1.68
Lars2LSXLateral septal complex0.17
0.12
Lars2MBMidbrain0.56
0.66
Lars2MYMedulla0.95
1
Lars2OLFOlfactory bulb4.08
3.43
Lars2PPons0.73
0.85
Lars2PALPallidum0.91
0.68
Lars2RHPRetrohippocampal region2.27
1.73
Lars2sAMYStriatum-like amygdalar nuclei0.28
0.15
Lars2STRStriatum0.83
0.54
Lars2STRdStriatum dorsal region0.99
0.65
Lars2STRvStriatum ventral region1.09
0.65
Lars2THThalamus1.88
1.64
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00075458 13 143 155 NLHPQSWTQSNIK Peptide Atlas
SYLM_HUMAN_420 12 420 431 QDAFLALTQKAR PRIDE
SYLM_HUMAN_691 11 691 701 WQQRLWTLTTR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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