AutismKB 2.0

Annotation Detail for DICER1


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Basic Information Top
Gene Symbol:DICER1 ( DCR1,Dicer,HERNA,KIAA0928 )
Gene Full Name: dicer 1, ribonuclease type III
Band: 14q32.13
Quick LinksEntrez ID:23405; OMIM: 606241; Uniprot ID:DICER_HUMAN; ENSEMBL ID: ENSG00000100697; HGNC ID: 17098
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body7 / 7076198
blastocyst8 / 62319128
fetus43 / 56401276
neonate2 / 3109764
infant0 / 236200 
juvenile2 / 5555635
adult119 / 193912161
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor9 / 9417895
cervical tumor0 / 343660 
chondrosarcoma7 / 8282384
colorectal tumor2 / 11424617
esophageal tumor1 / 1729057
gastrointestinal tumor4 / 11936933
germ cell tumor16 / 26384560
glioma2 / 10688318
head and neck tumor5 / 13630236
kidney tumor3 / 6895943
leukemia4 / 9584241
liver tumor3 / 9635931
lung tumor0 / 1031270 
lymphoma4 / 7175555
non-neoplasia7 / 9725071
normal245 / 336030772
ovarian tumor2 / 7668226
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer8 / 10268077
retinoblastoma1 / 4635621
skin tumor4 / 12494932
soft tissue/muscle tissue tumor6 / 12519147
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder3 / 29757100
blood4 / 12347832
bone7 / 7165597
bone marrow1 / 4880120
brain63 / 110098957
cervix0 / 481710 
connective tissue8 / 14925553
ear0 / 162120 
embryonic tissue27 / 215722125
esophagus1 / 2020949
eye20 / 21105494
heart5 / 8962655
intestine3 / 23447212
kidney9 / 21177742
larynx0 / 241450 
liver4 / 20774319
lung20 / 33697459
lymph0 / 442700 
lymph node17 / 91610185
mammary gland17 / 153271110
mouth3 / 6705244
muscle11 / 107715102
nerve1 / 1576863
ovary3 / 10205129
pancreas16 / 21481274
parathyroid1 / 2053948
pharynx2 / 4132848
pituitary gland2 / 16585120
placenta13 / 28082546
prostate11 / 18934558
salivary gland0 / 201550 
skin14 / 21057466
spleen0 / 539520 
stomach4 / 9661941
testis13 / 33044239
thymus6 / 8113173
thyroid0 / 474730 
tonsil0 / 169990 
trachea4 / 5241376
umbilical cord2 / 13680146
uterus11 / 23287847
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 206061_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts68.55
Adipocyte10
AdrenalCortex10.4
Adrenalgland8.5
Amygdala11.65
Appendix10.3
AtrioventricularNode8.1
BDCA4+_DentriticCells13.8
Bonemarrow10.25
BronchialEpithelialCells9.95
CD105+_Endothelial10.7
CD14+_Monocytes15.95
CD19+_BCells(neg._sel.)12.7
CD33+_Myeloid41.15
CD34+21.85
CD4+_Tcells15.2
CD56+_NKCells15.55
CD71+_EarlyErythroid7.95
CD8+_Tcells13.05
CardiacMyocytes12.75
Caudatenucleus9
Cerebellum8.3
CerebellumPeduncles11.7
CiliaryGanglion7.35
CingulateCortex9.9
Colorectaladenocarcinoma10.1
DorsalRootGanglion8
FetalThyroid10.05
Fetalbrain12.35
Fetalliver9.6
Fetallung8.85
GlobusPallidus7.4
Heart12.75
Hypothalamus11.15
Kidney8.25
Leukemia_chronicMyelogenousK-5628.15
Leukemia_promyelocytic-HL-608.15
Leukemialymphoblastic(MOLT-4)8.35
Liver13.25
Lung10.2
Lymphnode8.75
Lymphoma_burkitts(Daudi)12.85
Lymphoma_burkitts(Raji)14
MedullaOblongata9.85
OccipitalLobe10.5
OlfactoryBulb10.4
Ovary6.7
Pancreas7.45
PancreaticIslet10.1
ParietalLobe13.5
Pituitary32.35
Placenta10.85
Pons9.65
PrefrontalCortex18.4
Prostate16
Salivarygland7.65
SkeletalMuscle11.5
Skin7.65
SmoothMuscle9.45
Spinalcord10.7
SubthalamicNucleus9.4
SuperiorCervicalGanglion11.95
TemporalLobe9.25
Testis8.25
TestisGermCell8
TestisIntersitial8.4
TestisLeydigCell9.95
TestisSeminiferousTubule8.65
Thalamus10.35
Thymus10.4
Thyroid15.15
Tongue10.2
Tonsil9.9
Trachea9.55
TrigeminalGanglion10.15
Uterus25.15
UterusCorpus9
WholeBlood18.9
Wholebrain7.65
colon10.25
pineal_day17.8
pineal_night13.74
retina10.8
small_intestine9.75
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P22163
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.25 ± 0.2
Basal Forebrain9.68 ± 0.31
Basal Part of Pons9.28 ± 0.29
Cerebellar Cortex9.32 ± 0.13
Cerebellar Nuclei9.64 ± 0.31
Claustrum9.55 ± 0.25
Epithalamus9.66 ± 0.28
Frontal Lobe9.22 ± 0.33
Globus Pallidus10.02 ± 0.19
Hypothalamus9.21 ± 0.17
Insula9.07 ± 0.23
Limbic Lobe9.24 ± 0.3
Mesencephalon9.43 ± 0.36
Myelencephalon9.37 ± 0.33
Occipital Lobe9.57 ± 0.25
Parietal Lobe9.35 ± 0.31
Pontine Tegmentum9.36 ± 0.34
Striatum9.57 ± 0.3
Subthalamus9.46 ± 0.12
Temporal Lobe9.27 ± 0.24
Thalamus9.43 ± 0.29
White Matter10.91 ± 0.33
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Dicer1CBCerebellum1.11
1
Dicer1CTXCerebral cortex4.99
1.62
Dicer1HIPHippocampal region7.33
3.9
Dicer1HPFHippocampal formation6.47
2.67
Dicer1HYHypothalamus1.11
0.38
Dicer1LSXLateral septal complex1.56
0.42
Dicer1MBMidbrain1.23
0.46
Dicer1MYMedulla1.87
0.91
Dicer1OLFOlfactory bulb4.57
1.21
Dicer1PPons3.98
1.58
Dicer1PALPallidum0.75
0.33
Dicer1RHPRetrohippocampal region5.24
1.22
Dicer1sAMYStriatum-like amygdalar nuclei2.71
1.36
Dicer1STRStriatum0.82
0.38
Dicer1STRdStriatum dorsal region0.37
0.19
Dicer1STRvStriatum ventral region0.93
0.48
Dicer1THThalamus1.48
0.51
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
DICER_HUMAN_1830 12 1830 1841 PLIEKFSANVPR PRIDE
PAp00096146 17 355 371 IHALCEEHFSPASLDLK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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