AutismKB 2.0

Annotation Detail for CBX6


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Basic Information Top
Gene Symbol:CBX6 ( - )
Gene Full Name: chromobox homolog 6
Band: 22q13.1
Quick LinksEntrez ID:23466; OMIM: NA; Uniprot ID:CBX6_HUMAN; ENSEMBL ID: ENSG00000183741; HGNC ID: 1556
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body7 / 7076198
blastocyst1 / 6231916
fetus6 / 56401210
neonate0 / 310970 
infant1 / 2362042
juvenile10 / 55556179
adult54 / 193912127
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor0 / 343660 
chondrosarcoma4 / 8282348
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor6 / 26384522
glioma7 / 10688365
head and neck tumor7 / 13630251
kidney tumor4 / 6895958
leukemia3 / 9584231
liver tumor0 / 963590 
lung tumor5 / 10312748
lymphoma13 / 71755181
non-neoplasia0 / 972500 
normal99 / 336030729
ovarian tumor1 / 7668213
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS13 / 125680103
prostate cancer4 / 10268038
retinoblastoma5 / 46356107
skin tumor24 / 124949192
soft tissue/muscle tissue tumor13 / 125191103
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood2 / 12347816
bone4 / 7165555
bone marrow1 / 4880120
brain33 / 110098929
cervix1 / 4817120
connective tissue1 / 1492556
ear1 / 1621261
embryonic tissue9 / 21572241
esophagus0 / 202090 
eye22 / 211054104
heart0 / 896260 
intestine3 / 23447212
kidney5 / 21177723
larynx1 / 2414541
liver0 / 2077430 
lung8 / 33697423
lymph6 / 44270135
lymph node10 / 91610109
mammary gland3 / 15327119
mouth0 / 670520 
muscle3 / 10771527
nerve4 / 15768253
ovary3 / 10205129
pancreas8 / 21481237
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta4 / 28082514
prostate5 / 18934526
salivary gland5 / 20155248
skin27 / 210574128
spleen5 / 5395292
stomach0 / 966190 
testis0 / 3304420 
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus17 / 23287872
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202048_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts157.85
Adipocyte77
AdrenalCortex77.45
Adrenalgland79.45
Amygdala99.05
Appendix76.9
AtrioventricularNode56.1
BDCA4+_DentriticCells271.9
Bonemarrow75.15
BronchialEpithelialCells58.25
CD105+_Endothelial78.9
CD14+_Monocytes80.85
CD19+_BCells(neg._sel.)81.95
CD33+_Myeloid115.9
CD34+100.7
CD4+_Tcells86.6
CD56+_NKCells139.1
CD71+_EarlyErythroid71.85
CD8+_Tcells77.2
CardiacMyocytes95.85
Caudatenucleus236.7
Cerebellum364.45
CerebellumPeduncles250.75
CiliaryGanglion48
CingulateCortex346.6
Colorectaladenocarcinoma78.5
DorsalRootGanglion56.55
FetalThyroid81.85
Fetalbrain97.6
Fetalliver66.05
Fetallung65.45
GlobusPallidus202.45
Heart96.35
Hypothalamus121.25
Kidney62.45
Leukemia_chronicMyelogenousK-56270.15
Leukemia_promyelocytic-HL-6088.95
Leukemialymphoblastic(MOLT-4)56.25
Liver99.8
Lung86.55
Lymphnode49.75
Lymphoma_burkitts(Daudi)99.4
Lymphoma_burkitts(Raji)106.35
MedullaOblongata317.5
OccipitalLobe296.6
OlfactoryBulb61.25
Ovary50.5
Pancreas61.65
PancreaticIslet157.45
ParietalLobe186.1
Pituitary147.8
Placenta66.1
Pons272.2
PrefrontalCortex575.75
Prostate92.2
Salivarygland61.05
SkeletalMuscle88.25
Skin57.1
SmoothMuscle93.85
Spinalcord84.45
SubthalamicNucleus310.05
SuperiorCervicalGanglion83.85
TemporalLobe636.8
Testis62.4
TestisGermCell47.7
TestisIntersitial64.85
TestisLeydigCell41.1
TestisSeminiferousTubule57.45
Thalamus134.45
Thymus62.9
Thyroid98.25
Tongue73.55
Tonsil75.25
Trachea64.95
TrigeminalGanglion56.9
Uterus64.55
UterusCorpus73.55
WholeBlood72.85
Wholebrain346.4
colon77.85
pineal_day97.54
pineal_night95.38
retina127.725
small_intestine70.45
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_1945_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.65 ± 0.66
Basal Forebrain6.59 ± 0.33
Basal Part of Pons6.3 ± 0.49
Cerebellar Cortex6.21 ± 0.47
Cerebellar Nuclei6.04 ± 0.4
Claustrum7.34 ± 0.72
Epithalamus5.78 ± 0.67
Frontal Lobe6.52 ± 0.7
Globus Pallidus6.17 ± 0.49
Hypothalamus6.01 ± 0.48
Insula6.61 ± 0.48
Limbic Lobe7.24 ± 0.68
Mesencephalon6.6 ± 0.69
Myelencephalon6.74 ± 0.68
Occipital Lobe7.22 ± 0.73
Parietal Lobe6.78 ± 0.62
Pontine Tegmentum6.7 ± 0.53
Striatum7.05 ± 0.56
Subthalamus6.28 ± 0.32
Temporal Lobe6.73 ± 0.58
Thalamus6.56 ± 0.48
White Matter6.01 ± 0.57
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Cbx6CBCerebellum55.79
80.4
Cbx6CTXCerebral cortex100
100
Cbx6HIPHippocampal region70.91
100
Cbx6HPFHippocampal formation71.72
92.43
Cbx6HYHypothalamus8.22
6.65
Cbx6LSXLateral septal complex20.55
16.1
Cbx6MBMidbrain22.62
23.45
Cbx6MYMedulla31.87
38.49
Cbx6OLFOlfactory bulb63.84
67.48
Cbx6PPons21.15
25.19
Cbx6PALPallidum13.36
12.6
Cbx6RHPRetrohippocampal region74.73
68.06
Cbx6sAMYStriatum-like amygdalar nuclei30.38
25.28
Cbx6STRStriatum54.9
44.94
Cbx6STRdStriatum dorsal region68.42
56.71
Cbx6STRvStriatum ventral region37.92
30.77
Cbx6THThalamus38.61
43.97
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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