AutismKB 2.0

Annotation Detail for BRD4


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Basic Information Top
Gene Symbol:BRD4 ( CAP,HUNK1,HUNKI,MCAP )
Gene Full Name: bromodomain containing 4
Band: 19p13.12
Quick LinksEntrez ID:23476; OMIM: 608749; Uniprot ID:BRD4_HUMAN; ENSEMBL ID: ENSG00000141867; HGNC ID: 13575
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body9 / 70761127
blastocyst4 / 6231964
fetus46 / 56401281
neonate3 / 3109796
infant3 / 23620127
juvenile3 / 5555653
adult154 / 193912179
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma2 / 17475114
breast (mammary gland) tumor9 / 9417895
cervical tumor1 / 3436629
chondrosarcoma9 / 82823108
colorectal tumor14 / 114246122
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor22 / 26384583
glioma15 / 106883140
head and neck tumor16 / 136302117
kidney tumor6 / 6895987
leukemia7 / 9584273
liver tumor23 / 96359238
lung tumor18 / 103127174
lymphoma8 / 71755111
non-neoplasia10 / 97250102
normal261 / 336030777
ovarian tumor9 / 76682117
pancreatic tumor7 / 10461666
primitive neuroectodermal tumor of the CNS7 / 12568055
prostate cancer6 / 10268058
retinoblastoma5 / 46356107
skin tumor6 / 12494948
soft tissue/muscle tissue tumor11 / 12519187
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites1 / 4001524
bladder3 / 29757100
blood9 / 12347872
bone10 / 71655139
bone marrow1 / 4880120
brain64 / 110098958
cervix1 / 4817120
connective tissue10 / 14925566
ear0 / 162120 
embryonic tissue19 / 21572288
esophagus0 / 202090 
eye20 / 21105494
heart3 / 8962633
intestine25 / 234472106
kidney8 / 21177737
larynx3 / 24145124
liver31 / 207743149
lung34 / 336974100
lymph7 / 44270158
lymph node32 / 91610349
mammary gland16 / 153271104
mouth3 / 6705244
muscle9 / 10771583
nerve1 / 1576863
ovary15 / 102051146
pancreas21 / 21481297
parathyroid0 / 205390 
pharynx2 / 4132848
pituitary gland1 / 1658560
placenta29 / 280825103
prostate12 / 18934563
salivary gland6 / 20155297
skin12 / 21057456
spleen1 / 5395218
stomach0 / 966190 
testis23 / 33044269
thymus3 / 8113136
thyroid5 / 47473105
tonsil2 / 16999117
trachea0 / 524130 
umbilical cord2 / 13680146
uterus18 / 23287877
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202102_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts539.4
Adipocyte167.45
AdrenalCortex172.35
Adrenalgland111.55
Amygdala129.4
Appendix35.6
AtrioventricularNode7.5
BDCA4+_DentriticCells441.8
Bonemarrow203.1
BronchialEpithelialCells147.55
CD105+_Endothelial698.45
CD14+_Monocytes430.45
CD19+_BCells(neg._sel.)765.05
CD33+_Myeloid682.1
CD34+739.2
CD4+_Tcells326.95
CD56+_NKCells587.55
CD71+_EarlyErythroid645.3
CD8+_Tcells314.25
CardiacMyocytes112.95
Caudatenucleus22.05
Cerebellum90.7
CerebellumPeduncles233
CiliaryGanglion17.15
CingulateCortex220.45
Colorectaladenocarcinoma159.75
DorsalRootGanglion17.65
FetalThyroid275.8
Fetalbrain73.3
Fetalliver68.4
Fetallung100.1
GlobusPallidus40.25
Heart197.65
Hypothalamus63.25
Kidney81.05
Leukemia_chronicMyelogenousK-562122.15
Leukemia_promyelocytic-HL-6062.1
Leukemialymphoblastic(MOLT-4)147.25
Liver297.25
Lung762.8
Lymphnode67.4
Lymphoma_burkitts(Daudi)62.8
Lymphoma_burkitts(Raji)383.15
MedullaOblongata140.15
OccipitalLobe130.8
OlfactoryBulb222.3
Ovary82.1
Pancreas179.35
PancreaticIslet146.9
ParietalLobe158.85
Pituitary124.45
Placenta376.75
Pons102.15
PrefrontalCortex483.65
Prostate671.45
Salivarygland22.75
SkeletalMuscle154.2
Skin36.4
SmoothMuscle194.25
Spinalcord21.35
SubthalamicNucleus96.3
SuperiorCervicalGanglion26
TemporalLobe148.8
Testis183.35
TestisGermCell292.8
TestisIntersitial190.4
TestisLeydigCell145.25
TestisSeminiferousTubule289.4
Thalamus20.8
Thymus302.65
Thyroid171.55
Tongue192.95
Tonsil266.2
Trachea93.65
TrigeminalGanglion40.2
Uterus360.3
UterusCorpus130.65
WholeBlood176.5
Wholebrain232.85
colon111.6
pineal_day178
pineal_night190.4
retina138.825
small_intestine144.75
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_16262_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.55 ± 0.46
Basal Forebrain5.09 ± 0.24
Basal Part of Pons4.98 ± 0.55
Cerebellar Cortex4.94 ± 0.35
Cerebellar Nuclei4.7 ± 0.46
Claustrum5.7 ± 0.46
Epithalamus4.56 ± 0.33
Frontal Lobe4.96 ± 0.46
Globus Pallidus5.22 ± 0.42
Hypothalamus4.92 ± 0.45
Insula5.1 ± 0.47
Limbic Lobe5.38 ± 0.44
Mesencephalon5 ± 0.49
Myelencephalon5.06 ± 0.46
Occipital Lobe5.21 ± 0.38
Parietal Lobe5.19 ± 0.48
Pontine Tegmentum5.11 ± 0.4
Striatum5.09 ± 0.45
Subthalamus5.32 ± 0.42
Temporal Lobe5.15 ± 0.44
Thalamus4.88 ± 0.4
White Matter5.36 ± 0.41
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Brd4CBCerebellum0.8
2.41
Brd4CTXCerebral cortex0.97
1.77
Brd4HIPHippocampal region0.42
0.98
Brd4HPFHippocampal formation0.47
0.91
Brd4HYHypothalamus0.33
0.44
Brd4LSXLateral septal complex0.24
0.31
Brd4MBMidbrain1.16
3.04
Brd4MYMedulla0.66
1.95
Brd4OLFOlfactory bulb1.15
1.62
Brd4PPons2.51
4.56
Brd4PALPallidum0.25
0.37
Brd4RHPRetrohippocampal region0.48
0.76
Brd4sAMYStriatum-like amygdalar nuclei0.78
1.18
Brd4STRStriatum0.35
0.6
Brd4STRdStriatum dorsal region0.37
0.6
Brd4STRvStriatum ventral region0.18
0.56
Brd4THThalamus0.34
0.52
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
BRD4_HUMAN_1326 6 1326 1331 ELARKR PRIDE
BRD4_HUMAN_445 9 445 453 KLQDVFEMR PRIDE
BRD4_HUMAN_76 23 76 98 HQFAWPFQQPVDAVKLNLPDYYK PRIDE
PAp00043330 19 377 395 YKPVDVEALGLHDYCDIIK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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