AutismKB 2.0

Annotation Detail for SEC61G


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Basic Information Top
Gene Symbol:SEC61G ( SSS1 )
Gene Full Name: Sec61 gamma subunit
Band: 7p11.2
Quick LinksEntrez ID:23480; OMIM: 609215; Uniprot ID:SC61G_HUMAN; ENSEMBL ID: ENSG00000132432; HGNC ID: 18277
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body6 / 7076184
blastocyst15 / 62319240
fetus40 / 56401270
neonate2 / 3109764
infant1 / 2362042
juvenile0 / 555560 
adult86 / 193912144
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor10 / 94178106
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor6 / 11936950
germ cell tumor7 / 26384526
glioma7 / 10688365
head and neck tumor8 / 13630258
kidney tumor5 / 6895972
leukemia2 / 9584220
liver tumor3 / 9635931
lung tumor10 / 10312796
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal197 / 336030758
ovarian tumor1 / 7668213
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer8 / 10268077
retinoblastoma1 / 4635621
skin tumor3 / 12494924
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland6 / 33197180
ascites2 / 4001549
bladder0 / 297570 
blood3 / 12347824
bone2 / 7165527
bone marrow8 / 48801163
brain28 / 110098925
cervix0 / 481710 
connective tissue1 / 1492556
ear1 / 1621261
embryonic tissue30 / 215722139
esophagus0 / 202090 
eye5 / 21105423
heart9 / 89626100
intestine11 / 23447246
kidney10 / 21177747
larynx3 / 24145124
liver19 / 20774391
lung23 / 33697468
lymph0 / 442700 
lymph node1 / 9161010
mammary gland10 / 15327165
mouth3 / 6705244
muscle11 / 107715102
nerve0 / 157680 
ovary1 / 1020519
pancreas5 / 21481223
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland2 / 16585120
placenta6 / 28082521
prostate13 / 18934568
salivary gland2 / 2015599
skin5 / 21057423
spleen1 / 5395218
stomach8 / 9661982
testis16 / 33044248
thymus4 / 8113149
thyroid0 / 474730 
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord2 / 13680146
uterus11 / 23287847
vascular4 / 5178077
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203484_at
Cell line Expression level Expression bar
721_B_lymphoblasts1167.35
Adipocyte281.35
AdrenalCortex132.05
Adrenalgland118.65
Amygdala132.45
Appendix92.9
AtrioventricularNode51.15
BDCA4+_DentriticCells1339.05
Bonemarrow176.8
BronchialEpithelialCells1472.7
CD105+_Endothelial656.3
CD14+_Monocytes520.4
CD19+_BCells(neg._sel.)501.05
CD33+_Myeloid587.7
CD34+649.6
CD4+_Tcells331.95
CD56+_NKCells620.5
CD71+_EarlyErythroid211.95
CD8+_Tcells266.7
CardiacMyocytes1351.6
Caudatenucleus64.55
Cerebellum92.9
CerebellumPeduncles158.25
CiliaryGanglion36.05
CingulateCortex70.3
Colorectaladenocarcinoma419.95
DorsalRootGanglion67.6
FetalThyroid220.1
Fetalbrain254.15
Fetalliver168
Fetallung356.75
GlobusPallidus53.7
Heart337.55
Hypothalamus259.1
Kidney64.6
Leukemia_chronicMyelogenousK-562480.75
Leukemia_promyelocytic-HL-60319.15
Leukemialymphoblastic(MOLT-4)346.95
Liver145.85
Lung172.05
Lymphnode181.75
Lymphoma_burkitts(Daudi)874.3
Lymphoma_burkitts(Raji)350.9
MedullaOblongata66
OccipitalLobe85.85
OlfactoryBulb95.4
Ovary217.7
Pancreas264.1
PancreaticIslet504.55
ParietalLobe78.3
Pituitary548.3
Placenta211.2
Pons72.25
PrefrontalCortex136.95
Prostate291.35
Salivarygland217.45
SkeletalMuscle35.5
Skin85.1
SmoothMuscle2085.75
Spinalcord131.8
SubthalamicNucleus79.3
SuperiorCervicalGanglion37
TemporalLobe97.65
Testis283.2
TestisGermCell275.55
TestisIntersitial231.15
TestisLeydigCell164.35
TestisSeminiferousTubule160.9
Thalamus133.05
Thymus267.25
Thyroid325.4
Tongue74.25
Tonsil237.85
Trachea214.45
TrigeminalGanglion80.45
Uterus172.45
UterusCorpus171.25
WholeBlood289.1
Wholebrain227.95
colon257.35
pineal_day311.1
pineal_night349.8
retina316.3
small_intestine279.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_7128_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.66 ± 0.26
Basal Forebrain8.48 ± 0.16
Basal Part of Pons8.69 ± 0.19
Cerebellar Cortex8.73 ± 0.29
Cerebellar Nuclei8.61 ± 0.36
Claustrum8.32 ± 0.47
Epithalamus8.5 ± 0.29
Frontal Lobe8.8 ± 0.27
Globus Pallidus8.74 ± 0.23
Hypothalamus9.18 ± 0.22
Insula8.85 ± 0.35
Limbic Lobe8.57 ± 0.42
Mesencephalon8.67 ± 0.36
Myelencephalon8.59 ± 0.39
Occipital Lobe8.2 ± 0.38
Parietal Lobe8.67 ± 0.35
Pontine Tegmentum8.67 ± 0.39
Striatum8.31 ± 0.3
Subthalamus8.68 ± 0.21
Temporal Lobe8.79 ± 0.29
Thalamus8.44 ± 0.33
White Matter8.73 ± 0.35
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Sec61gCBCerebellum8.29
7.84
Sec61gCTXCerebral cortex7.86
3.71
Sec61gHIPHippocampal region6.35
4.63
Sec61gHPFHippocampal formation6.54
3.48
Sec61gHYHypothalamus4.39
1.9
Sec61gLSXLateral septal complex2.65
1.29
Sec61gMBMidbrain2.78
1.8
Sec61gMYMedulla14.18
8.08
Sec61gOLFOlfactory bulb6.82
3.04
Sec61gPPons6.96
3.32
Sec61gPALPallidum6.7
2.97
Sec61gRHPRetrohippocampal region6.85
2.01
Sec61gsAMYStriatum-like amygdalar nuclei1.95
0.5
Sec61gSTRStriatum1.65
0.89
Sec61gSTRdStriatum dorsal region1.17
0.84
Sec61gSTRvStriatum ventral region2.68
1.09
Sec61gTHThalamus9.03
5.06
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
SC61G_HUMAN_1 12 1 12 MDQVMQFVEPSR PRIDE
SC61G_HUMAN_13 8 13 20 QFVKDSIR PRIDE
SC61G_HUMAN_2 11 2 12 DQVMQFVEPSR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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