AutismKB 2.0

Annotation Detail for TMEM131


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Basic Information Top
Gene Symbol:TMEM131 ( CC28,KIAA0257,PRO1048,RW1,YR-23 )
Gene Full Name: transmembrane protein 131
Band: 2q11.2
Quick LinksEntrez ID:23505; OMIM: NA; Uniprot ID:TM131_HUMAN; ENSEMBL ID: ENSG00000075568; HGNC ID: 30366
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst3 / 6231948
fetus37 / 56401265
neonate1 / 3109732
infant0 / 236200 
juvenile0 / 555560 
adult109 / 193912156
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma11 / 82823132
colorectal tumor6 / 11424652
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor17 / 26384564
glioma7 / 10688365
head and neck tumor4 / 13630229
kidney tumor4 / 6895958
leukemia9 / 9584293
liver tumor0 / 963590 
lung tumor3 / 10312729
lymphoma2 / 7175527
non-neoplasia5 / 9725051
normal178 / 336030752
ovarian tumor6 / 7668278
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer12 / 102680116
retinoblastoma1 / 4635621
skin tumor5 / 12494940
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites1 / 4001524
bladder1 / 2975733
blood5 / 12347840
bone7 / 7165597
bone marrow0 / 488010 
brain49 / 110098944
cervix0 / 481710 
connective tissue7 / 14925546
ear4 / 16212246
embryonic tissue13 / 21572260
esophagus0 / 202090 
eye1 / 2110544
heart0 / 896260 
intestine11 / 23447246
kidney11 / 21177751
larynx1 / 2414541
liver3 / 20774314
lung13 / 33697438
lymph0 / 442700 
lymph node24 / 91610261
mammary gland1 / 1532716
mouth3 / 6705244
muscle4 / 10771537
nerve1 / 1576863
ovary6 / 10205158
pancreas9 / 21481241
parathyroid1 / 2053948
pharynx4 / 4132896
pituitary gland0 / 165850 
placenta13 / 28082546
prostate17 / 18934589
salivary gland0 / 201550 
skin13 / 21057461
spleen2 / 5395237
stomach1 / 9661910
testis29 / 33044287
thymus5 / 8113161
thyroid1 / 4747321
tonsil0 / 169990 
trachea6 / 52413114
umbilical cord0 / 136800 
uterus13 / 23287855
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 212507_at
Cell line Expression level Expression bar
721_B_lymphoblasts155.25
Adipocyte34.1
AdrenalCortex28.8
Adrenalgland33.7
Amygdala175.7
Appendix30.2
AtrioventricularNode21.4
BDCA4+_DentriticCells305.7
Bonemarrow37.05
BronchialEpithelialCells59.5
CD105+_Endothelial129.9
CD14+_Monocytes124.15
CD19+_BCells(neg._sel.)175.95
CD33+_Myeloid247.2
CD34+176.8
CD4+_Tcells173
CD56+_NKCells158.65
CD71+_EarlyErythroid26.65
CD8+_Tcells172.5
CardiacMyocytes42.2
Caudatenucleus30.9
Cerebellum26.9
CerebellumPeduncles23.15
CiliaryGanglion20.9
CingulateCortex23.8
Colorectaladenocarcinoma106.95
DorsalRootGanglion19.3
FetalThyroid25.3
Fetalbrain87.65
Fetalliver30.3
Fetallung30.2
GlobusPallidus15.45
Heart36.35
Hypothalamus45.4
Kidney19
Leukemia_chronicMyelogenousK-56222.9
Leukemia_promyelocytic-HL-6027.25
Leukemialymphoblastic(MOLT-4)37.8
Liver37.8
Lung79.45
Lymphnode105.1
Lymphoma_burkitts(Daudi)100.7
Lymphoma_burkitts(Raji)117.5
MedullaOblongata25.3
OccipitalLobe37.75
OlfactoryBulb18.2
Ovary13.65
Pancreas25.85
PancreaticIslet33.7
ParietalLobe27.9
Pituitary54.1
Placenta123.35
Pons21.25
PrefrontalCortex62.3
Prostate208.3
Salivarygland28.45
SkeletalMuscle26.45
Skin25.7
SmoothMuscle52.95
Spinalcord44.4
SubthalamicNucleus26.25
SuperiorCervicalGanglion28.75
TemporalLobe16.65
Testis33.75
TestisGermCell37.5
TestisIntersitial38.35
TestisLeydigCell31.15
TestisSeminiferousTubule24.95
Thalamus37.9
Thymus78.85
Thyroid101.65
Tongue26.35
Tonsil84.75
Trachea56.55
TrigeminalGanglion29.65
Uterus203.6
UterusCorpus18.4
WholeBlood133.9
Wholebrain57
colon288.65
pineal_day112.76
pineal_night134.9
retina59.3
small_intestine149.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P368558
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.75 ± 0.4
Basal Forebrain6.56 ± 0.24
Basal Part of Pons6.83 ± 0.18
Cerebellar Cortex6.74 ± 0.23
Cerebellar Nuclei6.44 ± 0.41
Claustrum6.86 ± 0.32
Epithalamus6.41 ± 0.22
Frontal Lobe6.83 ± 0.24
Globus Pallidus6.17 ± 0.23
Hypothalamus6.64 ± 0.22
Insula6.86 ± 0.27
Limbic Lobe6.75 ± 0.28
Mesencephalon6.68 ± 0.33
Myelencephalon6.73 ± 0.32
Occipital Lobe6.58 ± 0.31
Parietal Lobe6.73 ± 0.26
Pontine Tegmentum6.68 ± 0.31
Striatum6.74 ± 0.35
Subthalamus6.63 ± 0.29
Temporal Lobe6.79 ± 0.3
Thalamus6.99 ± 0.27
White Matter6.72 ± 0.17
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tmem131CBCerebellum44.28
54.56
Tmem131CTXCerebral cortex100
79.56
Tmem131HIPHippocampal region67.59
91.62
Tmem131HPFHippocampal formation82.05
84.94
Tmem131HYHypothalamus45.66
26.35
Tmem131LSXLateral septal complex69.63
36.02
Tmem131MBMidbrain45.77
28.37
Tmem131MYMedulla60.48
54.49
Tmem131OLFOlfactory bulb91.12
83.2
Tmem131PPons46.8
34.32
Tmem131PALPallidum49.66
30.95
Tmem131RHPRetrohippocampal region90.63
70.53
Tmem131sAMYStriatum-like amygdalar nuclei69.66
36.46
Tmem131STRStriatum69.96
36.13
Tmem131STRdStriatum dorsal region69.99
35.67
Tmem131STRvStriatum ventral region75.05
39.72
Tmem131THThalamus98.39
93.73
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00524337 25 1415 1439 DSLADDDSSSTTTETSNPDTEPLLK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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