AutismKB 2.0

Annotation Detail for PRAME


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Basic Information Top
Gene Symbol:PRAME ( CT130,MAPE,OIP4 )
Gene Full Name: preferentially expressed antigen in melanoma
Band: 22q11.22
Quick LinksEntrez ID:23532; OMIM: 606021; Uniprot ID:PRAME_HUMAN; ENSEMBL ID: ENSG00000185686; HGNC ID: 9336
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus3 / 5640125
neonate0 / 310970 
infant0 / 236200 
juvenile35 / 55556629
adult82 / 193912142
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor4 / 9417842
cervical tumor2 / 3436658
chondrosarcoma1 / 8282312
colorectal tumor1 / 1142468
esophageal tumor4 / 17290231
gastrointestinal tumor8 / 11936967
germ cell tumor10 / 26384537
glioma0 / 1068830 
head and neck tumor11 / 13630280
kidney tumor6 / 6895987
leukemia41 / 95842427
liver tumor3 / 9635931
lung tumor5 / 10312748
lymphoma1 / 7175513
non-neoplasia0 / 972500 
normal86 / 336030725
ovarian tumor5 / 7668265
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS55 / 125680437
prostate cancer15 / 102680146
retinoblastoma23 / 46356496
skin tumor115 / 124949920
soft tissue/muscle tissue tumor6 / 12519147
uterine tumor33 / 90257365
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites1 / 4001524
bladder0 / 297570 
blood12 / 12347897
bone0 / 716550 
bone marrow29 / 48801594
brain60 / 110098954
cervix14 / 48171290
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus4 / 20209197
eye24 / 211054113
heart0 / 896260 
intestine7 / 23447229
kidney7 / 21177733
larynx5 / 24145207
liver3 / 20774314
lung5 / 33697414
lymph1 / 4427022
lymph node0 / 916100 
mammary gland4 / 15327126
mouth6 / 6705289
muscle0 / 1077150 
nerve0 / 157680 
ovary9 / 10205188
pancreas2 / 2148129
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta5 / 28082517
prostate15 / 18934579
salivary gland2 / 2015599
skin115 / 210574546
spleen0 / 539520 
stomach2 / 9661920
testis79 / 330442239
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus42 / 232878180
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204086_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.05
Adipocyte4.8
AdrenalCortex5.25
Adrenalgland4.25
Amygdala5.05
Appendix4.9
AtrioventricularNode3.9
BDCA4+_DentriticCells5.4
Bonemarrow5.4
BronchialEpithelialCells5
CD105+_Endothelial5
CD14+_Monocytes5.3
CD19+_BCells(neg._sel.)5.25
CD33+_Myeloid6.35
CD34+6.3
CD4+_Tcells5.35
CD56+_NKCells5.9
CD71+_EarlyErythroid4.65
CD8+_Tcells4.75
CardiacMyocytes6.55
Caudatenucleus4.4
Cerebellum4
CerebellumPeduncles5.65
CiliaryGanglion3.9
CingulateCortex5.15
Colorectaladenocarcinoma4.85
DorsalRootGanglion4.5
FetalThyroid4.8
Fetalbrain4.9
Fetalliver4.25
Fetallung3.9
GlobusPallidus4
Heart6.85
Hypothalamus5.3
Kidney4.1
Leukemia_chronicMyelogenousK-5621616.4
Leukemia_promyelocytic-HL-604.35
Leukemialymphoblastic(MOLT-4)4
Liver6.5
Lung5.35
Lymphnode4.25
Lymphoma_burkitts(Daudi)6.25
Lymphoma_burkitts(Raji)6.85
MedullaOblongata4.55
OccipitalLobe4.45
OlfactoryBulb3.9
Ovary3.35
Pancreas3.95
PancreaticIslet5.25
ParietalLobe5.5
Pituitary5.75
Placenta4.95
Pons4.75
PrefrontalCortex6.25
Prostate5.85
Salivarygland4.05
SkeletalMuscle5.85
Skin3.95
SmoothMuscle5.55
Spinalcord5.3
SubthalamicNucleus5.1
SuperiorCervicalGanglion5.7
TemporalLobe4.6
Testis60.25
TestisGermCell134.05
TestisIntersitial118.15
TestisLeydigCell21.95
TestisSeminiferousTubule56.5
Thalamus5.05
Thymus3.8
Thyroid6.05
Tongue4.9
Tonsil4.8
Trachea4.15
TrigeminalGanglion4.95
Uterus4
UterusCorpus4.45
WholeBlood5.35
Wholebrain4.15
colon4.9
pineal_day6.16
pineal_night5.92
retina5.95
small_intestine4.75
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P216361
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.44 ± 1.06
Basal Forebrain1.91 ± 0.23
Basal Part of Pons1.82 ± 0.58
Cerebellar Cortex1.84 ± 0.75
Cerebellar Nuclei2.35 ± 0.79
Claustrum2.89 ± 0.86
Epithalamus1.57 ± 0.7
Frontal Lobe1.84 ± 0.69
Globus Pallidus2.51 ± 0.31
Hypothalamus2.02 ± 0.73
Insula1.76 ± 0.48
Limbic Lobe2.04 ± 0.7
Mesencephalon2.09 ± 0.65
Myelencephalon2.1 ± 0.8
Occipital Lobe2.25 ± 1.07
Parietal Lobe1.93 ± 0.59
Pontine Tegmentum1.99 ± 0.61
Striatum2.14 ± 0.51
Subthalamus2.35 ± 0.17
Temporal Lobe1.99 ± 0.76
Thalamus1.99 ± 0.66
White Matter2.43 ± 0.19
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00064090 17 141 157 ASLYSFPEPEAAQPMTK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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