AutismKB 2.0

Annotation Detail for MAPK8IP2


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Basic Information Top
Gene Symbol:MAPK8IP2 ( IB2,JIP2,PRKM8IPL )
Gene Full Name: mitogen-activated protein kinase 8 interacting protein 2
Band: 22q13.33
Quick LinksEntrez ID:23542; OMIM: 607755; Uniprot ID:JIP2_HUMAN; ENSEMBL ID: ENSG00000008735; HGNC ID: 6883
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus4 / 5640127
neonate0 / 310970 
infant1 / 2362042
juvenile0 / 555560 
adult50 / 193912125
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor1 / 1729057
gastrointestinal tumor1 / 1193698
germ cell tumor3 / 26384511
glioma5 / 10688346
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal63 / 336030718
ovarian tumor1 / 7668213
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS4 / 12568031
prostate cancer1 / 1026809
retinoblastoma1 / 4635621
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites1 / 4001524
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain57 / 110098951
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus1 / 2020949
eye7 / 21105433
heart0 / 896260 
intestine0 / 2344720 
kidney0 / 2117770 
larynx0 / 241450 
liver0 / 2077430 
lung3 / 3369748
lymph0 / 442700 
lymph node0 / 916100 
mammary gland2 / 15327113
mouth0 / 670520 
muscle1 / 1077159
nerve1 / 1576863
ovary1 / 1020519
pancreas8 / 21481237
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta4 / 28082514
prostate1 / 1893455
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis3 / 3304429
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 208603_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.3
Adipocyte4.3
AdrenalCortex4.7
Adrenalgland3.7
Amygdala39.75
Appendix4.4
AtrioventricularNode3.35
BDCA4+_DentriticCells4.6
Bonemarrow4.4
BronchialEpithelialCells4.25
CD105+_Endothelial4.35
CD14+_Monocytes4.6
CD19+_BCells(neg._sel.)4.6
CD33+_Myeloid5.55
CD34+5.45
CD4+_Tcells4.65
CD56+_NKCells5
CD71+_EarlyErythroid4.15
CD8+_Tcells4.1
CardiacMyocytes5.85
Caudatenucleus4.7
Cerebellum12.5
CerebellumPeduncles8.35
CiliaryGanglion3
CingulateCortex6.75
Colorectaladenocarcinoma4.4
DorsalRootGanglion3.35
FetalThyroid4.2
Fetalbrain6.9
Fetalliver3.9
Fetallung3.55
GlobusPallidus5.9
Heart5.75
Hypothalamus5.4
Kidney3.95
Leukemia_chronicMyelogenousK-5623.95
Leukemia_promyelocytic-HL-603.85
Leukemialymphoblastic(MOLT-4)3.5
Liver5.7
Lung4.85
Lymphnode3.8
Lymphoma_burkitts(Daudi)5.55
Lymphoma_burkitts(Raji)6.1
MedullaOblongata4.4
OccipitalLobe6.5
OlfactoryBulb3.45
Ovary2.9
Pancreas3.55
PancreaticIslet4.7
ParietalLobe5.85
Pituitary5.55
Placenta4.45
Pons6.85
PrefrontalCortex32.8
Prostate5.15
Salivarygland3.5
SkeletalMuscle5.1
Skin3.35
SmoothMuscle4.9
Spinalcord4.65
SubthalamicNucleus9.45
SuperiorCervicalGanglion4.85
TemporalLobe7.55
Testis4.25
TestisGermCell3.7
TestisIntersitial3.65
TestisLeydigCell4.3
TestisSeminiferousTubule3.75
Thalamus4.45
Thymus3.5
Thyroid5.5
Tongue4.2
Tonsil4.25
Trachea3.65
TrigeminalGanglion4.2
Uterus3.5
UterusCorpus3.85
WholeBlood4.65
Wholebrain23.6
colon4.35
pineal_day5.5
pineal_night5.38
retina5.25
small_intestine4.2
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_1265_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.81 ± 0.44
Basal Forebrain7.31 ± 0.27
Basal Part of Pons8.07 ± 0.23
Cerebellar Cortex7.71 ± 0.25
Cerebellar Nuclei7.43 ± 0.28
Claustrum8.04 ± 0.54
Epithalamus6.82 ± 0.28
Frontal Lobe7.5 ± 0.34
Globus Pallidus6.68 ± 0.17
Hypothalamus7.23 ± 0.27
Insula7.46 ± 0.26
Limbic Lobe7.68 ± 0.36
Mesencephalon7.3 ± 0.32
Myelencephalon7.46 ± 0.42
Occipital Lobe7.38 ± 0.25
Parietal Lobe7.45 ± 0.34
Pontine Tegmentum7.31 ± 0.32
Striatum6.91 ± 0.31
Subthalamus7.05 ± 0.23
Temporal Lobe7.59 ± 0.3
Thalamus7.43 ± 0.29
White Matter6.73 ± 0.27
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Mapk8ip2CBCerebellum48.21
80.51
Mapk8ip2CTXCerebral cortex100
100
Mapk8ip2HIPHippocampal region100
100
Mapk8ip2HPFHippocampal formation100
100
Mapk8ip2HYHypothalamus84.79
100
Mapk8ip2LSXLateral septal complex45.34
52.29
Mapk8ip2MBMidbrain69.07
93.12
Mapk8ip2MYMedulla50.25
98.34
Mapk8ip2OLFOlfactory bulb77.39
100
Mapk8ip2PPons67.22
100
Mapk8ip2PALPallidum79.64
100
Mapk8ip2RHPRetrohippocampal region100
100
Mapk8ip2sAMYStriatum-like amygdalar nuclei100
100
Mapk8ip2STRStriatum93.73
97.78
Mapk8ip2STRdStriatum dorsal region98.66
97.78
Mapk8ip2STRvStriatum ventral region92.65
95.64
Mapk8ip2THThalamus100
100
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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