AutismKB 2.0

Annotation Detail for PSD4


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Basic Information Top
Gene Symbol:PSD4 ( EFA6B,FLJ36237,FLJ37279,TIC )
Gene Full Name: pleckstrin and Sec7 domain containing 4
Band: 2q14.1
Quick LinksEntrez ID:23550; OMIM: NA; Uniprot ID:PSD4_HUMAN; ENSEMBL ID: ENSG00000125637; HGNC ID: 19096
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus17 / 56401230
neonate0 / 310970 
infant0 / 236200 
juvenile2 / 5555635
adult78 / 193912140
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor4 / 9417842
cervical tumor0 / 343660 
chondrosarcoma2 / 8282324
colorectal tumor3 / 11424626
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor8 / 26384530
glioma0 / 1068830 
head and neck tumor5 / 13630236
kidney tumor0 / 689590 
leukemia8 / 9584283
liver tumor2 / 9635920
lung tumor4 / 10312738
lymphoma21 / 71755292
non-neoplasia2 / 9725020
normal102 / 336030730
ovarian tumor2 / 7668226
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor2 / 12494916
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites1 / 4001524
bladder0 / 297570 
blood9 / 12347872
bone3 / 7165541
bone marrow6 / 48801122
brain13 / 110098911
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus0 / 202090 
eye8 / 21105437
heart3 / 8962633
intestine9 / 23447238
kidney3 / 21177714
larynx0 / 241450 
liver6 / 20774328
lung15 / 33697444
lymph17 / 44270384
lymph node13 / 91610141
mammary gland7 / 15327145
mouth0 / 670520 
muscle1 / 1077159
nerve2 / 15768126
ovary3 / 10205129
pancreas12 / 21481255
parathyroid2 / 2053997
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta7 / 28082524
prostate1 / 1893455
salivary gland1 / 2015549
skin2 / 2105749
spleen1 / 5395218
stomach1 / 9661910
testis12 / 33044236
thymus28 / 81131345
thyroid6 / 47473126
tonsil2 / 16999117
trachea0 / 524130 
umbilical cord0 / 136800 
uterus5 / 23287821
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203317_at
Cell line Expression level Expression bar
721_B_lymphoblasts234.6
Adipocyte34.05
AdrenalCortex40.45
Adrenalgland32.95
Amygdala39.75
Appendix36.75
AtrioventricularNode29.5
BDCA4+_DentriticCells249.7
Bonemarrow47.2
BronchialEpithelialCells37.35
CD105+_Endothelial48.9
CD14+_Monocytes168.25
CD19+_BCells(neg._sel.)149.65
CD33+_Myeloid171.3
CD34+88.4
CD4+_Tcells232.5
CD56+_NKCells363.95
CD71+_EarlyErythroid36.2
CD8+_Tcells301.5
CardiacMyocytes44.3
Caudatenucleus35.3
Cerebellum31.7
CerebellumPeduncles44.35
CiliaryGanglion27
CingulateCortex40.05
Colorectaladenocarcinoma45.95
DorsalRootGanglion29.55
FetalThyroid49.5
Fetalbrain39.6
Fetalliver34.7
Fetallung33.1
GlobusPallidus28.2
Heart49
Hypothalamus42.2
Kidney31.35
Leukemia_chronicMyelogenousK-56241.1
Leukemia_promyelocytic-HL-6036.45
Leukemialymphoblastic(MOLT-4)60.2
Liver53.3
Lung44.3
Lymphnode86.5
Lymphoma_burkitts(Daudi)56.8
Lymphoma_burkitts(Raji)68.65
MedullaOblongata32.35
OccipitalLobe34.55
OlfactoryBulb31.2
Ovary25.95
Pancreas32.65
PancreaticIslet42.15
ParietalLobe41.25
Pituitary45.2
Placenta49.8
Pons37.25
PrefrontalCortex48.6
Prostate89.7
Salivarygland31.25
SkeletalMuscle43.55
Skin29.5
SmoothMuscle39.25
Spinalcord42
SubthalamicNucleus31.9
SuperiorCervicalGanglion43.15
TemporalLobe35.8
Testis34.35
TestisGermCell32.5
TestisIntersitial32.25
TestisLeydigCell38.9
TestisSeminiferousTubule39.7
Thalamus39.45
Thymus115.9
Thyroid80
Tongue38.1
Tonsil43.85
Trachea33.2
TrigeminalGanglion38.45
Uterus32.65
UterusCorpus34.4
WholeBlood253.85
Wholebrain32.85
colon40.05
pineal_day49.2
pineal_night54.7
retina47.5
small_intestine38.25
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_1809_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.58 ± 0.99
Basal Forebrain1.92 ± 0.42
Basal Part of Pons1.91 ± 0.39
Cerebellar Cortex1.8 ± 0.81
Cerebellar Nuclei2.39 ± 0.68
Claustrum2.69 ± 0.87
Epithalamus1.53 ± 0.73
Frontal Lobe1.91 ± 0.85
Globus Pallidus2.59 ± 0.9
Hypothalamus2.06 ± 0.93
Insula1.71 ± 0.6
Limbic Lobe2.16 ± 0.74
Mesencephalon2.23 ± 0.81
Myelencephalon2.18 ± 0.74
Occipital Lobe2.1 ± 0.74
Parietal Lobe2.32 ± 0.93
Pontine Tegmentum2.03 ± 0.85
Striatum2.21 ± 0.68
Subthalamus1.85 ± 0.73
Temporal Lobe1.97 ± 0.73
Thalamus2.02 ± 0.71
White Matter2.69 ± 0.67
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Psd4CBCerebellum0.86
1.42
Psd4CTXCerebral cortex1
1.17
Psd4HIPHippocampal region0.62
0.75
Psd4HPFHippocampal formation0.58
0.57
Psd4HYHypothalamus0.05
0.2
Psd4LSXLateral septal complex0
0
Psd4MBMidbrain1.11
1.37
Psd4MYMedulla0.4
0.55
Psd4OLFOlfactory bulb0.61
0.48
Psd4PPons0.32
0.56
Psd4PALPallidum0.08
0.07
Psd4RHPRetrohippocampal region0.54
0.35
Psd4sAMYStriatum-like amygdalar nuclei0.08
0.06
Psd4STRStriatum0.27
0.44
Psd4STRdStriatum dorsal region0.42
0.72
Psd4STRvStriatum ventral region0.04
0.02
Psd4THThalamus0.29
0.33
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00040171 26 35 60 ETCSHEDPPEPFEEQTWATDPPEPTR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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