AutismKB 2.0

Annotation Detail for FPGS


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Basic Information Top
Gene Symbol:FPGS ( - )
Gene Full Name: folylpolyglutamate synthase
Band: 9q34.11
Quick LinksEntrez ID:2356; OMIM: 136510; Uniprot ID:FOLC_HUMAN; ENSEMBL ID: ENSG00000136877; HGNC ID: 3824
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst4 / 6231964
fetus21 / 56401237
neonate3 / 3109796
infant0 / 236200 
juvenile10 / 55556179
adult106 / 193912154
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor8 / 34366232
chondrosarcoma5 / 8282360
colorectal tumor5 / 11424643
esophageal tumor0 / 172900 
gastrointestinal tumor10 / 11936983
germ cell tumor44 / 263845166
glioma7 / 10688365
head and neck tumor3 / 13630222
kidney tumor9 / 68959130
leukemia13 / 95842135
liver tumor9 / 9635993
lung tumor15 / 103127145
lymphoma60 / 71755836
non-neoplasia8 / 9725082
normal160 / 336030747
ovarian tumor4 / 7668252
pancreatic tumor7 / 10461666
primitive neuroectodermal tumor of the CNS29 / 125680230
prostate cancer16 / 102680155
retinoblastoma0 / 463560 
skin tumor28 / 124949224
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor12 / 90257132
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites5 / 40015124
bladder3 / 29757100
blood12 / 12347897
bone6 / 7165583
bone marrow3 / 4880161
brain40 / 110098936
cervix19 / 48171394
connective tissue13 / 14925587
ear0 / 162120 
embryonic tissue14 / 21572264
esophagus0 / 202090 
eye3 / 21105414
heart5 / 8962655
intestine11 / 23447246
kidney17 / 21177780
larynx0 / 241450 
liver18 / 20774386
lung27 / 33697480
lymph39 / 44270880
lymph node14 / 91610152
mammary gland2 / 15327113
mouth1 / 6705214
muscle0 / 1077150 
nerve0 / 157680 
ovary13 / 102051127
pancreas8 / 21481237
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta17 / 28082560
prostate23 / 189345121
salivary gland0 / 201550 
skin32 / 210574151
spleen0 / 539520 
stomach6 / 9661962
testis20 / 33044260
thymus14 / 81131172
thyroid2 / 4747342
tonsil0 / 169990 
trachea3 / 5241357
umbilical cord0 / 136800 
uterus18 / 23287877
vascular9 / 51780173
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202945_at
Cell line Expression level Expression bar
721_B_lymphoblasts49.7
Adipocyte5.95
AdrenalCortex5.4
Adrenalgland4.85
Amygdala5.7
Appendix5.3
AtrioventricularNode3.9
BDCA4+_DentriticCells36.2
Bonemarrow5.2
BronchialEpithelialCells9.55
CD105+_Endothelial9.15
CD14+_Monocytes5.85
CD19+_BCells(neg._sel.)16.85
CD33+_Myeloid5.95
CD34+31.75
CD4+_Tcells11.35
CD56+_NKCells16.95
CD71+_EarlyErythroid4.95
CD8+_Tcells9.15
CardiacMyocytes6.6
Caudatenucleus4.8
Cerebellum4.3
CerebellumPeduncles5.95
CiliaryGanglion3.65
CingulateCortex5.35
Colorectaladenocarcinoma6.2
DorsalRootGanglion4
FetalThyroid5.05
Fetalbrain5.35
Fetalliver4.7
Fetallung4.5
GlobusPallidus4.85
Heart11.7
Hypothalamus5.85
Kidney4.25
Leukemia_chronicMyelogenousK-5624.8
Leukemia_promyelocytic-HL-604.7
Leukemialymphoblastic(MOLT-4)6.15
Liver14.3
Lung5.95
Lymphnode4.65
Lymphoma_burkitts(Daudi)6.75
Lymphoma_burkitts(Raji)8.25
MedullaOblongata4.6
OccipitalLobe4.8
OlfactoryBulb4.25
Ovary26.75
Pancreas7.5
PancreaticIslet5.7
ParietalLobe5.5
Pituitary6.2
Placenta5.6
Pons5.05
PrefrontalCortex6.75
Prostate6.55
Salivarygland4.45
SkeletalMuscle5.9
Skin3.95
SmoothMuscle6.1
Spinalcord5.7
SubthalamicNucleus4.8
SuperiorCervicalGanglion5.9
TemporalLobe4.8
Testis5
TestisGermCell4.2
TestisIntersitial4.45
TestisLeydigCell5.2
TestisSeminiferousTubule4.55
Thalamus5.35
Thymus4.3
Thyroid8.85
Tongue5.1
Tonsil5.2
Trachea4.45
TrigeminalGanglion5.15
Uterus4.4
UterusCorpus4.7
WholeBlood5.9
Wholebrain4.6
colon5.4
pineal_day6.68
pineal_night6.54
retina6.675
small_intestine5.2
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_13225_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.28 ± 0.56
Basal Forebrain4.65 ± 0.28
Basal Part of Pons4.56 ± 0.54
Cerebellar Cortex5.05 ± 0.38
Cerebellar Nuclei4.42 ± 0.56
Claustrum4.15 ± 0.63
Epithalamus5 ± 0.63
Frontal Lobe4.49 ± 0.52
Globus Pallidus4.95 ± 0.52
Hypothalamus4.43 ± 0.42
Insula4.28 ± 0.55
Limbic Lobe4.47 ± 0.58
Mesencephalon4.52 ± 0.57
Myelencephalon4.59 ± 0.52
Occipital Lobe4.68 ± 0.53
Parietal Lobe4.43 ± 0.46
Pontine Tegmentum4.39 ± 0.52
Striatum4.56 ± 0.65
Subthalamus4.66 ± 0.23
Temporal Lobe4.47 ± 0.44
Thalamus4.71 ± 0.52
White Matter5.62 ± 0.3
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
FpgsCBCerebellum6.74
6.8
FpgsCTXCerebral cortex4.9
3.96
FpgsHIPHippocampal region9.74
9.28
FpgsHPFHippocampal formation7.5
6.54
FpgsHYHypothalamus5.67
4.11
FpgsLSXLateral septal complex7.46
5.26
FpgsMBMidbrain3.49
3.09
FpgsMYMedulla7.64
7.2
FpgsOLFOlfactory bulb12.81
11.29
FpgsPPons5.89
5.37
FpgsPALPallidum7
5.39
FpgsRHPRetrohippocampal region2.54
1.76
FpgssAMYStriatum-like amygdalar nuclei0.43
0.25
FpgsSTRStriatum3.66
2.43
FpgsSTRdStriatum dorsal region0.62
0.57
FpgsSTRvStriatum ventral region8.42
4.68
FpgsTHThalamus6.77
5.09
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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