AutismKB 2.0

Annotation Detail for DDX58


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Basic Information Top
Gene Symbol:DDX58 ( DKFZp434J1111,DKFZp686N19181,FLJ13599,RIG-I )
Gene Full Name: DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
Band: 9p21.1
Quick LinksEntrez ID:23586; OMIM: 609631; Uniprot ID:DDX58_HUMAN; ENSEMBL ID: ENSG00000107201; HGNC ID: 19102
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus10 / 56401217
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult80 / 193912141
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor20 / 94178212
cervical tumor2 / 3436658
chondrosarcoma1 / 8282312
colorectal tumor3 / 11424626
esophageal tumor5 / 17290289
gastrointestinal tumor5 / 11936941
germ cell tumor7 / 26384526
glioma1 / 1068839
head and neck tumor6 / 13630244
kidney tumor2 / 6895929
leukemia5 / 9584252
liver tumor1 / 9635910
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal84 / 336030724
ovarian tumor1 / 7668213
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor2 / 12494916
soft tissue/muscle tissue tumor9 / 12519171
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites1 / 4001524
bladder3 / 29757100
blood6 / 12347848
bone1 / 7165513
bone marrow2 / 4880140
brain10 / 11009899
cervix2 / 4817141
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus5 / 20209247
eye0 / 2110540 
heart3 / 8962633
intestine9 / 23447238
kidney7 / 21177733
larynx0 / 241450 
liver2 / 2077439
lung3 / 3369748
lymph0 / 442700 
lymph node2 / 9161021
mammary gland24 / 153271156
mouth8 / 67052119
muscle8 / 10771574
nerve1 / 1576863
ovary2 / 10205119
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta9 / 28082532
prostate5 / 18934526
salivary gland0 / 201550 
skin4 / 21057418
spleen2 / 5395237
stomach4 / 9661941
testis11 / 33044233
thymus4 / 8113149
thyroid0 / 474730 
tonsil0 / 169990 
trachea5 / 5241395
umbilical cord0 / 136800 
uterus17 / 23287872
vascular4 / 5178077
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 218943_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts7
Adipocyte5.6
AdrenalCortex6.8
Adrenalgland5.05
Amygdala5.8
Appendix6.4
AtrioventricularNode16.85
BDCA4+_DentriticCells10
Bonemarrow5.95
BronchialEpithelialCells5.55
CD105+_Endothelial5.7
CD14+_Monocytes37.5
CD19+_BCells(neg._sel.)12.25
CD33+_Myeloid22.8
CD34+13.75
CD4+_Tcells78.6
CD56+_NKCells80.55
CD71+_EarlyErythroid5.45
CD8+_Tcells74.25
CardiacMyocytes8.6
Caudatenucleus5.15
Cerebellum4.7
CerebellumPeduncles6.8
CiliaryGanglion5.35
CingulateCortex5.95
Colorectaladenocarcinoma5.8
DorsalRootGanglion4.85
FetalThyroid6.85
Fetalbrain5.55
Fetalliver5.1
Fetallung4.45
GlobusPallidus4.55
Heart8.2
Hypothalamus6
Kidney5.05
Leukemia_chronicMyelogenousK-5625.2
Leukemia_promyelocytic-HL-605.1
Leukemialymphoblastic(MOLT-4)4.5
Liver8.15
Lung6.2
Lymphnode5.15
Lymphoma_burkitts(Daudi)8.35
Lymphoma_burkitts(Raji)8.55
MedullaOblongata5.2
OccipitalLobe5.1
OlfactoryBulb4.5
Ovary4.1
Pancreas4.7
PancreaticIslet6.15
ParietalLobe6.3
Pituitary6.7
Placenta5.75
Pons5.6
PrefrontalCortex6.95
Prostate6.6
Salivarygland4.9
SkeletalMuscle8.35
Skin5.2
SmoothMuscle6.9
Spinalcord6.1
SubthalamicNucleus5.4
SuperiorCervicalGanglion12.4
TemporalLobe5.3
Testis4.9
TestisGermCell4.6
TestisIntersitial4.85
TestisLeydigCell5.85
TestisSeminiferousTubule4.85
Thalamus5.9
Thymus4.35
Thyroid6.95
Tongue6.6
Tonsil5.9
Trachea4.8
TrigeminalGanglion6.4
Uterus4.55
UterusCorpus5.45
WholeBlood34.55
Wholebrain4.6
colon5.7
pineal_day7.1
pineal_night6.94
retina7
small_intestine5.5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_14979_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.06 ± 0.53
Basal Forebrain5.16 ± 0.32
Basal Part of Pons5.35 ± 0.22
Cerebellar Cortex4.84 ± 0.23
Cerebellar Nuclei5.22 ± 0.41
Claustrum5 ± 0.4
Epithalamus5.25 ± 0.36
Frontal Lobe4.87 ± 0.4
Globus Pallidus5.81 ± 0.32
Hypothalamus5.11 ± 0.75
Insula4.95 ± 0.28
Limbic Lobe4.89 ± 0.5
Mesencephalon4.99 ± 0.44
Myelencephalon5.09 ± 0.42
Occipital Lobe5.21 ± 0.31
Parietal Lobe4.83 ± 0.4
Pontine Tegmentum4.84 ± 0.45
Striatum5.31 ± 0.38
Subthalamus4.78 ± 0.49
Temporal Lobe4.88 ± 0.38
Thalamus4.99 ± 0.33
White Matter6.14 ± 0.2
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ddx58CBCerebellum13.36
17.05
Ddx58CTXCerebral cortex16.78
11.94
Ddx58HIPHippocampal region9.86
10.15
Ddx58HPFHippocampal formation11.22
10.53
Ddx58HYHypothalamus0.75
0.6
Ddx58LSXLateral septal complex0.41
0.29
Ddx58MBMidbrain7.14
6.72
Ddx58MYMedulla10.53
11.54
Ddx58OLFOlfactory bulb10.92
8.25
Ddx58PPons8.25
8.84
Ddx58PALPallidum0.89
0.83
Ddx58RHPRetrohippocampal region13.4
10.99
Ddx58sAMYStriatum-like amygdalar nuclei0.5
0.46
Ddx58STRStriatum1.29
1.06
Ddx58STRdStriatum dorsal region1.59
1.36
Ddx58STRvStriatum ventral region1.24
0.89
Ddx58THThalamus3
2.34
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00034758 14 489 502 ICKDLENLSQIQNR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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