AutismKB 2.0

Annotation Detail for LEMD3


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Basic Information Top
Gene Symbol:LEMD3 ( MAN1 )
Gene Full Name: LEM domain containing 3
Band: 12q14.3
Quick LinksEntrez ID:23592; OMIM: 607844; Uniprot ID:MAN1_HUMAN; ENSEMBL ID: ENSG00000174106; HGNC ID: 28887
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst3 / 6231948
fetus18 / 56401231
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult33 / 193912117
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma1 / 1747557
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor1 / 1142468
esophageal tumor1 / 1729057
gastrointestinal tumor4 / 11936933
germ cell tumor6 / 26384522
glioma1 / 1068839
head and neck tumor3 / 13630222
kidney tumor1 / 6895914
leukemia6 / 9584262
liver tumor2 / 9635920
lung tumor2 / 10312719
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal83 / 336030724
ovarian tumor3 / 7668239
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer0 / 1026800 
retinoblastoma1 / 4635621
skin tumor2 / 12494916
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites0 / 400150 
bladder4 / 29757134
blood6 / 12347848
bone0 / 716550 
bone marrow0 / 488010 
brain17 / 110098915
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue7 / 21572232
esophagus1 / 2020949
eye3 / 21105414
heart1 / 8962611
intestine7 / 23447229
kidney6 / 21177728
larynx0 / 241450 
liver6 / 20774328
lung8 / 33697423
lymph0 / 442700 
lymph node9 / 9161098
mammary gland0 / 1532710 
mouth1 / 6705214
muscle5 / 10771546
nerve0 / 157680 
ovary3 / 10205129
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta8 / 28082528
prostate3 / 18934515
salivary gland0 / 201550 
skin4 / 21057418
spleen1 / 5395218
stomach2 / 9661920
testis7 / 33044221
thymus3 / 8113136
thyroid2 / 4747342
tonsil0 / 169990 
trachea5 / 5241395
umbilical cord0 / 136800 
uterus5 / 23287821
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 218604_at
Cell line Expression level Expression bar
721_B_lymphoblasts55.85
Adipocyte23.65
AdrenalCortex26.4
Adrenalgland19.6
Amygdala30.4
Appendix28.15
AtrioventricularNode22.8
BDCA4+_DentriticCells180.1
Bonemarrow26.1
BronchialEpithelialCells56.8
CD105+_Endothelial115.3
CD14+_Monocytes36.9
CD19+_BCells(neg._sel.)163.3
CD33+_Myeloid114.95
CD34+157.6
CD4+_Tcells113.6
CD56+_NKCells125.8
CD71+_EarlyErythroid141.65
CD8+_Tcells131.2
CardiacMyocytes37.9
Caudatenucleus21.75
Cerebellum21.6
CerebellumPeduncles37.75
CiliaryGanglion17.55
CingulateCortex23.4
Colorectaladenocarcinoma27.1
DorsalRootGanglion27.7
FetalThyroid27.2
Fetalbrain41.45
Fetalliver20.7
Fetallung31.35
GlobusPallidus17.5
Heart27.4
Hypothalamus35.25
Kidney17.35
Leukemia_chronicMyelogenousK-56220.95
Leukemia_promyelocytic-HL-6029.8
Leukemialymphoblastic(MOLT-4)24.65
Liver29.3
Lung27.8
Lymphnode27.45
Lymphoma_burkitts(Daudi)43
Lymphoma_burkitts(Raji)39.3
MedullaOblongata27.55
OccipitalLobe25.4
OlfactoryBulb21.65
Ovary21.2
Pancreas20.2
PancreaticIslet23.85
ParietalLobe28.1
Pituitary26.8
Placenta31.45
Pons19.3
PrefrontalCortex73.45
Prostate52.85
Salivarygland17.45
SkeletalMuscle29.1
Skin21.25
SmoothMuscle26.65
Spinalcord18.45
SubthalamicNucleus21
SuperiorCervicalGanglion38.35
TemporalLobe24.15
Testis25.05
TestisGermCell35.45
TestisIntersitial29.2
TestisLeydigCell27.65
TestisSeminiferousTubule39
Thalamus17.6
Thymus22.85
Thyroid32.1
Tongue25.8
Tonsil23.7
Trachea18.8
TrigeminalGanglion26.9
Uterus93.3
UterusCorpus22.05
WholeBlood55.65
Wholebrain24.05
colon51.1
pineal_day43.8
pineal_night70.4
retina42.375
small_intestine39.5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_1705_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.04 ± 0.43
Basal Forebrain6.76 ± 0.25
Basal Part of Pons7.06 ± 0.28
Cerebellar Cortex7.03 ± 0.24
Cerebellar Nuclei6.43 ± 0.58
Claustrum7.01 ± 0.37
Epithalamus6.61 ± 0.51
Frontal Lobe6.81 ± 0.35
Globus Pallidus6.18 ± 0.39
Hypothalamus6.85 ± 0.26
Insula6.85 ± 0.48
Limbic Lobe7.07 ± 0.39
Mesencephalon6.78 ± 0.39
Myelencephalon6.83 ± 0.4
Occipital Lobe7.05 ± 0.35
Parietal Lobe6.95 ± 0.35
Pontine Tegmentum6.84 ± 0.36
Striatum7.06 ± 0.32
Subthalamus6.64 ± 0.43
Temporal Lobe6.86 ± 0.34
Thalamus6.77 ± 0.35
White Matter7.15 ± 0.4
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Lemd3CBCerebellum18.92
20.56
Lemd3CTXCerebral cortex33.93
26.58
Lemd3HIPHippocampal region27.26
32.7
Lemd3HPFHippocampal formation28
28.71
Lemd3HYHypothalamus5.81
5.41
Lemd3LSXLateral septal complex12.77
9.54
Lemd3MBMidbrain11.01
9.97
Lemd3MYMedulla20.45
20.3
Lemd3OLFOlfactory bulb29.09
23.97
Lemd3PPons11.7
12.88
Lemd3PALPallidum5.2
4.92
Lemd3RHPRetrohippocampal region29.92
24.19
Lemd3sAMYStriatum-like amygdalar nuclei7.49
5.95
Lemd3STRStriatum7.28
6.28
Lemd3STRdStriatum dorsal region6.2
5.99
Lemd3STRvStriatum ventral region9.65
6.62
Lemd3THThalamus9.06
7.83
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
MAN1_HUMAN_153 7 153 159 QAGGGGR PRIDE
MAN1_HUMAN_2 21 2 22 AAAAASAPQQLSDEELFSQLR PRIDE
MAN1_HUMAN_93 10 93 102 PVSGDLSYLR PRIDE
PAp00096312 16 538 553 LAQLAGDHECGSSSQR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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