AutismKB 2.0

Annotation Detail for RUSC1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:RUSC1 ( DKFZp761A1822,NESCA )
Gene Full Name: RUN and SH3 domain containing 1
Band: 1q22
Quick LinksEntrez ID:23623; OMIM: NA; Uniprot ID:RUSC1_HUMAN; ENSEMBL ID: ENSG00000160753; HGNC ID: 17153
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst4 / 6231964
fetus45 / 56401279
neonate4 / 31097128
infant4 / 23620169
juvenile3 / 5555653
adult145 / 193912174
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor8 / 9417884
cervical tumor9 / 34366261
chondrosarcoma6 / 8282372
colorectal tumor7 / 11424661
esophageal tumor3 / 17290173
gastrointestinal tumor9 / 11936975
germ cell tumor25 / 26384594
glioma10 / 10688393
head and neck tumor4 / 13630229
kidney tumor1 / 6895914
leukemia4 / 9584241
liver tumor6 / 9635962
lung tumor5 / 10312748
lymphoma2 / 7175527
non-neoplasia4 / 9725041
normal253 / 336030775
ovarian tumor8 / 76682104
pancreatic tumor6 / 10461657
primitive neuroectodermal tumor of the CNS33 / 125680262
prostate cancer12 / 102680116
retinoblastoma3 / 4635664
skin tumor1 / 1249498
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites4 / 4001599
bladder3 / 29757100
blood6 / 12347848
bone3 / 7165541
bone marrow2 / 4880140
brain143 / 1100989129
cervix18 / 48171373
connective tissue5 / 14925533
ear1 / 1621261
embryonic tissue15 / 21572269
esophagus3 / 20209148
eye19 / 21105490
heart2 / 8962622
intestine16 / 23447268
kidney4 / 21177718
larynx1 / 2414541
liver8 / 20774338
lung18 / 33697453
lymph0 / 442700 
lymph node0 / 916100 
mammary gland8 / 15327152
mouth0 / 670520 
muscle1 / 1077159
nerve1 / 1576863
ovary12 / 102051117
pancreas10 / 21481246
parathyroid0 / 205390 
pharynx2 / 4132848
pituitary gland0 / 165850 
placenta23 / 28082581
prostate18 / 18934595
salivary gland0 / 201550 
skin6 / 21057428
spleen2 / 5395237
stomach6 / 9661962
testis15 / 33044245
thymus10 / 81131123
thyroid2 / 4747342
tonsil0 / 169990 
trachea4 / 5241376
umbilical cord3 / 13680219
uterus10 / 23287842
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 206949_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts30.35
Adipocyte13.9
AdrenalCortex17.1
Adrenalgland35.6
Amygdala156.65
Appendix18.5
AtrioventricularNode11.35
BDCA4+_DentriticCells21.1
Bonemarrow27.55
BronchialEpithelialCells97.45
CD105+_Endothelial87.05
CD14+_Monocytes35.3
CD19+_BCells(neg._sel.)9.05
CD33+_Myeloid69.45
CD34+122.75
CD4+_Tcells23.8
CD56+_NKCells58.05
CD71+_EarlyErythroid51.45
CD8+_Tcells19.3
CardiacMyocytes20.8
Caudatenucleus85.8
Cerebellum253.05
CerebellumPeduncles163.2
CiliaryGanglion31.5
CingulateCortex64.1
Colorectaladenocarcinoma40.85
DorsalRootGanglion37.05
FetalThyroid27.05
Fetalbrain301.75
Fetalliver27.75
Fetallung29
GlobusPallidus57.6
Heart60.35
Hypothalamus219.5
Kidney51.7
Leukemia_chronicMyelogenousK-56244.8
Leukemia_promyelocytic-HL-609.3
Leukemialymphoblastic(MOLT-4)19.3
Liver15.1
Lung35.8
Lymphnode13.85
Lymphoma_burkitts(Daudi)31.8
Lymphoma_burkitts(Raji)7.7
MedullaOblongata153.55
OccipitalLobe114.35
OlfactoryBulb27.65
Ovary11.25
Pancreas16.95
PancreaticIslet24.6
ParietalLobe81.65
Pituitary49.85
Placenta68.65
Pons55.5
PrefrontalCortex114.7
Prostate65.95
Salivarygland26.7
SkeletalMuscle18.5
Skin11.65
SmoothMuscle17
Spinalcord66.2
SubthalamicNucleus54.1
SuperiorCervicalGanglion38.75
TemporalLobe90.1
Testis16
TestisGermCell13.9
TestisIntersitial11.85
TestisLeydigCell11.15
TestisSeminiferousTubule10.25
Thalamus173.8
Thymus73.6
Thyroid24.25
Tongue40.3
Tonsil17.7
Trachea43.45
TrigeminalGanglion34.6
Uterus12.2
UterusCorpus12.8
WholeBlood17.25
Wholebrain240.85
colon53.15
pineal_day69.64
pineal_night50.22
retina64.475
small_intestine42.7
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_5360_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.51 ± 0.53
Basal Forebrain6.89 ± 0.32
Basal Part of Pons7.05 ± 0.59
Cerebellar Cortex6.82 ± 0.58
Cerebellar Nuclei7.06 ± 0.51
Claustrum7.91 ± 0.75
Epithalamus5.88 ± 0.92
Frontal Lobe6.88 ± 0.6
Globus Pallidus7.04 ± 0.54
Hypothalamus6.61 ± 0.6
Insula6.82 ± 0.54
Limbic Lobe7.27 ± 0.6
Mesencephalon7.1 ± 0.71
Myelencephalon7.06 ± 0.62
Occipital Lobe7.6 ± 0.62
Parietal Lobe7.23 ± 0.58
Pontine Tegmentum7.01 ± 0.5
Striatum6.73 ± 0.51
Subthalamus6.99 ± 0.09
Temporal Lobe6.95 ± 0.53
Thalamus7.26 ± 0.45
White Matter5.03 ± 0.77
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Rusc1CBCerebellum100
100
Rusc1CTXCerebral cortex100
100
Rusc1HIPHippocampal region87
100
Rusc1HPFHippocampal formation100
100
Rusc1HYHypothalamus100
100
Rusc1LSXLateral septal complex92.22
69.27
Rusc1MBMidbrain100
100
Rusc1MYMedulla100
100
Rusc1OLFOlfactory bulb100
100
Rusc1PPons100
100
Rusc1PALPallidum100
100
Rusc1RHPRetrohippocampal region100
100
Rusc1sAMYStriatum-like amygdalar nuclei100
89.32
Rusc1STRStriatum100
91.04
Rusc1STRdStriatum dorsal region99.45
84.68
Rusc1STRvStriatum ventral region100
100
Rusc1THThalamus100
100
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved