AutismKB 2.0

Annotation Detail for HSPBP1


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Basic Information Top
Gene Symbol:HSPBP1 ( FES1 )
Gene Full Name: HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
Band: 19q13.42
Quick LinksEntrez ID:23640; OMIM: 612939; Uniprot ID:HPBP1_HUMAN; ENSEMBL ID: ENSG00000133265; HGNC ID: 24989
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body10 / 70761141
blastocyst9 / 62319144
fetus30 / 56401253
neonate0 / 310970 
infant5 / 23620211
juvenile12 / 55556215
adult153 / 193912178
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor3 / 3436687
chondrosarcoma10 / 82823120
colorectal tumor9 / 11424678
esophageal tumor0 / 172900 
gastrointestinal tumor17 / 119369142
germ cell tumor11 / 26384541
glioma21 / 106883196
head and neck tumor2 / 13630214
kidney tumor3 / 6895943
leukemia7 / 9584273
liver tumor11 / 96359114
lung tumor26 / 103127252
lymphoma28 / 71755390
non-neoplasia9 / 9725092
normal248 / 336030773
ovarian tumor7 / 7668291
pancreatic tumor30 / 104616286
primitive neuroectodermal tumor of the CNS46 / 125680366
prostate cancer7 / 10268068
retinoblastoma7 / 46356151
skin tumor18 / 124949144
soft tissue/muscle tissue tumor14 / 125191111
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites9 / 40015224
bladder0 / 297570 
blood15 / 123478121
bone12 / 71655167
bone marrow1 / 4880120
brain124 / 1100989112
cervix18 / 48171373
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue27 / 215722125
esophagus0 / 202090 
eye32 / 211054151
heart2 / 8962622
intestine15 / 23447263
kidney10 / 21177747
larynx0 / 241450 
liver18 / 20774386
lung52 / 336974154
lymph16 / 44270361
lymph node2 / 9161021
mammary gland4 / 15327126
mouth0 / 670520 
muscle10 / 10771592
nerve2 / 15768126
ovary15 / 102051146
pancreas38 / 214812176
parathyroid1 / 2053948
pharynx1 / 4132824
pituitary gland3 / 16585180
placenta22 / 28082578
prostate9 / 18934547
salivary gland0 / 201550 
skin23 / 210574109
spleen3 / 5395255
stomach10 / 96619103
testis23 / 33044269
thymus3 / 8113136
thyroid0 / 474730 
tonsil1 / 1699958
trachea0 / 524130 
umbilical cord0 / 136800 
uterus11 / 23287847
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202415_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts108.2
Adipocyte31.75
AdrenalCortex34.25
Adrenalgland27.55
Amygdala41.7
Appendix18.1
AtrioventricularNode24.7
BDCA4+_DentriticCells36.8
Bonemarrow32.3
BronchialEpithelialCells33.45
CD105+_Endothelial89.55
CD14+_Monocytes35.25
CD19+_BCells(neg._sel.)40.85
CD33+_Myeloid41.95
CD34+94.5
CD4+_Tcells36.35
CD56+_NKCells45.85
CD71+_EarlyErythroid30.8
CD8+_Tcells27.05
CardiacMyocytes42.85
Caudatenucleus68.1
Cerebellum28.15
CerebellumPeduncles38.9
CiliaryGanglion22.9
CingulateCortex42.95
Colorectaladenocarcinoma101.2
DorsalRootGanglion25.2
FetalThyroid32.65
Fetalbrain49.95
Fetalliver28.35
Fetallung34.05
GlobusPallidus27.35
Heart72
Hypothalamus36.2
Kidney26.85
Leukemia_chronicMyelogenousK-56230.3
Leukemia_promyelocytic-HL-6029.3
Leukemialymphoblastic(MOLT-4)26.75
Liver44.65
Lung44.95
Lymphnode28.05
Lymphoma_burkitts(Daudi)53.15
Lymphoma_burkitts(Raji)46.2
MedullaOblongata31.8
OccipitalLobe33.95
OlfactoryBulb26.1
Ovary21.55
Pancreas26.25
PancreaticIslet42.1
ParietalLobe34.95
Pituitary36.7
Placenta33.95
Pons31.3
PrefrontalCortex52.4
Prostate38.9
Salivarygland26.1
SkeletalMuscle35.8
Skin25.15
SmoothMuscle37.6
Spinalcord37.05
SubthalamicNucleus30.1
SuperiorCervicalGanglion36.15
TemporalLobe30.35
Testis32.95
TestisGermCell30.85
TestisIntersitial27.45
TestisLeydigCell28.1
TestisSeminiferousTubule29.9
Thalamus33.85
Thymus26.25
Thyroid43.25
Tongue32
Tonsil31.9
Trachea27.4
TrigeminalGanglion25.5
Uterus26.8
UterusCorpus21.2
WholeBlood28.35
Wholebrain128.2
colon33.2
pineal_day46
pineal_night47.92
retina39.85
small_intestine31.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P10685
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala10.39 ± 0.39
Basal Forebrain10.42 ± 0.22
Basal Part of Pons10.66 ± 0.2
Cerebellar Cortex10.07 ± 0.12
Cerebellar Nuclei10.55 ± 0.44
Claustrum10.31 ± 0.28
Epithalamus10.6 ± 0.67
Frontal Lobe10.57 ± 0.31
Globus Pallidus9.89 ± 0.48
Hypothalamus10.24 ± 0.27
Insula10.59 ± 0.22
Limbic Lobe10.51 ± 0.38
Mesencephalon10.28 ± 0.3
Myelencephalon10.43 ± 0.39
Occipital Lobe10.03 ± 0.28
Parietal Lobe10.38 ± 0.31
Pontine Tegmentum10.35 ± 0.31
Striatum11.07 ± 0.29
Subthalamus10.59 ± 0.11
Temporal Lobe10.5 ± 0.3
Thalamus10.28 ± 0.24
White Matter9.45 ± 0.37
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
1500019G21RikCBCerebellum31.95
39.29
1500019G21RikCTXCerebral cortex100
100
1500019G21RikHIPHippocampal region82.2
100
1500019G21RikHPFHippocampal formation100
100
1500019G21RikHYHypothalamus92.41
56.9
1500019G21RikLSXLateral septal complex100
61.19
1500019G21RikMBMidbrain73.77
57.56
1500019G21RikMYMedulla69.23
75.01
1500019G21RikOLFOlfactory bulb100
98.05
1500019G21RikPPons85.3
75.46
1500019G21RikPALPallidum84.32
65.56
1500019G21RikRHPRetrohippocampal region100
100
1500019G21RiksAMYStriatum-like amygdalar nuclei100
70.06
1500019G21RikSTRStriatum67.59
34.11
1500019G21RikSTRdStriatum dorsal region56.25
26.21
1500019G21RikSTRvStriatum ventral region62.63
32.44
1500019G21RikTHThalamus100
99.86
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00007664 26 283 308 TEHSPFHEHVLGALCSLVTDFPQGVR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018