AutismKB 2.0

Annotation Detail for PPP1R15A


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Basic Information Top
Gene Symbol:PPP1R15A ( GADD34 )
Gene Full Name: protein phosphatase 1, regulatory (inhibitor) subunit 15A
Band: 19q13.2
Quick LinksEntrez ID:23645; OMIM: 611048; Uniprot ID:PR15A_HUMAN; ENSEMBL ID: ENSG00000087074; HGNC ID: 14375
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body6 / 7076184
blastocyst1 / 6231916
fetus53 / 56401293
neonate11 / 31097353
infant2 / 2362084
juvenile7 / 55556125
adult206 / 1939121106
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma3 / 17475171
breast (mammary gland) tumor5 / 9417853
cervical tumor2 / 3436658
chondrosarcoma25 / 82823301
colorectal tumor11 / 11424696
esophageal tumor10 / 17290578
gastrointestinal tumor10 / 11936983
germ cell tumor15 / 26384556
glioma6 / 10688356
head and neck tumor12 / 13630288
kidney tumor8 / 68959116
leukemia13 / 95842135
liver tumor6 / 9635962
lung tumor2 / 10312719
lymphoma1 / 7175513
non-neoplasia11 / 97250113
normal374 / 3360307111
ovarian tumor5 / 7668265
pancreatic tumor21 / 104616200
primitive neuroectodermal tumor of the CNS10 / 12568079
prostate cancer1 / 1026809
retinoblastoma3 / 4635664
skin tumor9 / 12494972
soft tissue/muscle tissue tumor14 / 125191111
uterine tumor16 / 90257177
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland4 / 33197120
ascites4 / 4001599
bladder7 / 29757235
blood24 / 123478194
bone5 / 7165569
bone marrow7 / 48801143
brain99 / 110098989
cervix2 / 4817141
connective tissue23 / 149255154
ear0 / 162120 
embryonic tissue11 / 21572250
esophagus10 / 20209494
eye18 / 21105485
heart11 / 89626122
intestine26 / 234472110
kidney24 / 211777113
larynx2 / 2414582
liver12 / 20774357
lung66 / 336974195
lymph1 / 4427022
lymph node6 / 9161065
mammary gland5 / 15327132
mouth4 / 6705259
muscle5 / 10771546
nerve2 / 15768126
ovary8 / 10205178
pancreas28 / 214812130
parathyroid4 / 20539194
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta43 / 280825153
prostate9 / 18934547
salivary gland0 / 201550 
skin34 / 210574161
spleen9 / 53952166
stomach10 / 96619103
testis7 / 33044221
thymus9 / 81131110
thyroid7 / 47473147
tonsil4 / 16999235
trachea10 / 52413190
umbilical cord1 / 1368073
uterus34 / 232878145
vascular7 / 51780135
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202014_at
Cell line Expression level Expression bar
721_B_lymphoblasts13.75
Adipocyte4.2
AdrenalCortex6.2
Adrenalgland5.15
Amygdala4.55
Appendix4.2
AtrioventricularNode3.15
BDCA4+_DentriticCells144.75
Bonemarrow6
BronchialEpithelialCells6.35
CD105+_Endothelial33.5
CD14+_Monocytes139.5
CD19+_BCells(neg._sel.)82.2
CD33+_Myeloid359.85
CD34+35.15
CD4+_Tcells5.45
CD56+_NKCells31.9
CD71+_EarlyErythroid193.4
CD8+_Tcells4.75
CardiacMyocytes10.35
Caudatenucleus3.85
Cerebellum3.45
CerebellumPeduncles4.75
CiliaryGanglion2.9
CingulateCortex4.25
Colorectaladenocarcinoma23.7
DorsalRootGanglion3.15
FetalThyroid4.15
Fetalbrain4.3
Fetalliver8.15
Fetallung5.6
GlobusPallidus3.05
Heart8.35
Hypothalamus4.55
Kidney3.4
Leukemia_chronicMyelogenousK-5625.2
Leukemia_promyelocytic-HL-604.4
Leukemialymphoblastic(MOLT-4)3.35
Liver10.95
Lung45.4
Lymphnode4.4
Lymphoma_burkitts(Daudi)5.35
Lymphoma_burkitts(Raji)7.25
MedullaOblongata3.9
OccipitalLobe4
OlfactoryBulb6.5
Ovary2.8
Pancreas10
PancreaticIslet14.6
ParietalLobe4.45
Pituitary5
Placenta8.55
Pons3.95
PrefrontalCortex6.1
Prostate6.95
Salivarygland3.25
SkeletalMuscle4.7
Skin3.2
SmoothMuscle8.65
Spinalcord4.45
SubthalamicNucleus3.8
SuperiorCervicalGanglion4.65
TemporalLobe3.85
Testis3.7
TestisGermCell5.65
TestisIntersitial3.5
TestisLeydigCell4.1
TestisSeminiferousTubule3.6
Thalamus4.25
Thymus4.1
Thyroid8.1
Tongue4.05
Tonsil4.05
Trachea7.35
TrigeminalGanglion4.1
Uterus4.5
UterusCorpus5.75
WholeBlood39.9
Wholebrain3.7
colon4.15
pineal_day6.82
pineal_night5.8
retina6.075
small_intestine4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_15941_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala1.92 ± 1.07
Basal Forebrain1.59 ± 0.41
Basal Part of Pons1.34 ± 0.59
Cerebellar Cortex1.54 ± 0.67
Cerebellar Nuclei1.86 ± 0.77
Claustrum2.37 ± 0.73
Epithalamus1.48 ± 0.78
Frontal Lobe1.6 ± 0.69
Globus Pallidus1.87 ± 0.66
Hypothalamus1.66 ± 0.69
Insula1.3 ± 0.62
Limbic Lobe1.63 ± 0.67
Mesencephalon1.73 ± 0.73
Myelencephalon1.7 ± 0.68
Occipital Lobe1.81 ± 0.86
Parietal Lobe1.53 ± 0.59
Pontine Tegmentum1.6 ± 0.72
Striatum1.73 ± 0.69
Subthalamus1.65 ± 0.68
Temporal Lobe1.56 ± 0.76
Thalamus1.57 ± 0.66
White Matter1.93 ± 0.64
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Myd116CBCerebellum18.75
21.62
Myd116CTXCerebral cortex33.97
25.46
Myd116HIPHippocampal region23.3
26.95
Myd116HPFHippocampal formation25.25
24.41
Myd116HYHypothalamus9.99
7.76
Myd116LSXLateral septal complex48.68
49.07
Myd116MBMidbrain9.32
8.54
Myd116MYMedulla17.36
17.93
Myd116OLFOlfactory bulb30.49
24.47
Myd116PPons12.48
13.65
Myd116PALPallidum17.98
16.5
Myd116RHPRetrohippocampal region28.79
20.91
Myd116sAMYStriatum-like amygdalar nuclei24.35
17.92
Myd116STRStriatum28.75
22.27
Myd116STRdStriatum dorsal region29.9
21.66
Myd116STRvStriatum ventral region21.36
17.64
Myd116THThalamus23.11
19.28
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00498763 16 78 93 RPEEEAEDSGGPGEDR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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