AutismKB 2.0

Annotation Detail for PLXNB2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:PLXNB2 ( KIAA0315,MM1,Nbla00445,PLEXB2,dJ402G11.3 )
Gene Full Name: plexin B2
Band: 22q13.33
Quick LinksEntrez ID:23654; OMIM: 604293; Uniprot ID:PLXB2_HUMAN; ENSEMBL ID: ENSG00000196576; HGNC ID: 9104
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body18 / 70761254
blastocyst3 / 6231948
fetus32 / 56401256
neonate3 / 3109796
infant0 / 236200 
juvenile6 / 55556107
adult219 / 1939121112
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma3 / 17475171
breast (mammary gland) tumor17 / 94178180
cervical tumor2 / 3436658
chondrosarcoma15 / 82823181
colorectal tumor34 / 114246297
esophageal tumor2 / 17290115
gastrointestinal tumor22 / 119369184
germ cell tumor34 / 263845128
glioma8 / 10688374
head and neck tumor28 / 136302205
kidney tumor25 / 68959362
leukemia0 / 958420 
liver tumor10 / 96359103
lung tumor9 / 10312787
lymphoma1 / 7175513
non-neoplasia6 / 9725061
normal275 / 336030781
ovarian tumor17 / 76682221
pancreatic tumor29 / 104616277
primitive neuroectodermal tumor of the CNS7 / 12568055
prostate cancer16 / 102680155
retinoblastoma5 / 46356107
skin tumor14 / 124949112
soft tissue/muscle tissue tumor21 / 125191167
uterine tumor22 / 90257243
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland3 / 3319790
ascites3 / 4001574
bladder5 / 29757168
blood3 / 12347824
bone5 / 7165569
bone marrow0 / 488010 
brain73 / 110098966
cervix5 / 48171103
connective tissue12 / 14925580
ear0 / 162120 
embryonic tissue32 / 215722148
esophagus3 / 20209148
eye31 / 211054146
heart4 / 8962644
intestine47 / 234472200
kidney33 / 211777155
larynx2 / 2414582
liver14 / 20774367
lung35 / 336974103
lymph1 / 4427022
lymph node24 / 91610261
mammary gland27 / 153271176
mouth10 / 67052149
muscle26 / 107715241
nerve7 / 15768443
ovary39 / 102051382
pancreas31 / 214812144
parathyroid2 / 2053997
pharynx6 / 41328145
pituitary gland2 / 16585120
placenta20 / 28082571
prostate28 / 189345147
salivary gland3 / 20155148
skin20 / 21057494
spleen4 / 5395274
stomach16 / 96619165
testis25 / 33044275
thymus2 / 8113124
thyroid11 / 47473231
tonsil0 / 169990 
trachea7 / 52413133
umbilical cord2 / 13680146
uterus30 / 232878128
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 208890_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts117.9
Adipocyte85.7
AdrenalCortex99.7
Adrenalgland88.5
Amygdala39.05
Appendix38.55
AtrioventricularNode27.95
BDCA4+_DentriticCells605.6
Bonemarrow16.85
BronchialEpithelialCells78.7
CD105+_Endothelial34.7
CD14+_Monocytes488.5
CD19+_BCells(neg._sel.)7.6
CD33+_Myeloid766
CD34+176.9
CD4+_Tcells7.85
CD56+_NKCells73.75
CD71+_EarlyErythroid7.4
CD8+_Tcells8.6
CardiacMyocytes99.75
Caudatenucleus35.75
Cerebellum64.3
CerebellumPeduncles124.9
CiliaryGanglion23.7
CingulateCortex35.6
Colorectaladenocarcinoma241.3
DorsalRootGanglion39.75
FetalThyroid226.8
Fetalbrain90.45
Fetalliver19.25
Fetallung130.45
GlobusPallidus19.45
Heart95.8
Hypothalamus39.7
Kidney125.6
Leukemia_chronicMyelogenousK-56216.45
Leukemia_promyelocytic-HL-6019.25
Leukemialymphoblastic(MOLT-4)9.65
Liver182.5
Lung355.55
Lymphnode64.55
Lymphoma_burkitts(Daudi)68.5
Lymphoma_burkitts(Raji)101
MedullaOblongata23.8
OccipitalLobe18.7
OlfactoryBulb83.85
Ovary45.15
Pancreas48.45
PancreaticIslet135.65
ParietalLobe19.25
Pituitary91
Placenta319.5
Pons25.1
PrefrontalCortex68.3
Prostate393.4
Salivarygland28.9
SkeletalMuscle28.7
Skin40.5
SmoothMuscle184.15
Spinalcord62.7
SubthalamicNucleus25.05
SuperiorCervicalGanglion22.45
TemporalLobe26.45
Testis59.25
TestisGermCell103.2
TestisIntersitial45.15
TestisLeydigCell51.9
TestisSeminiferousTubule59.75
Thalamus19.35
Thymus33.45
Thyroid467
Tongue76.45
Tonsil93.65
Trachea72.3
TrigeminalGanglion27.4
Uterus141.35
UterusCorpus88.45
WholeBlood90.15
Wholebrain26.95
colon49.25
pineal_day86.72
pineal_night120.16
retina116.2
small_intestine31.5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P70888
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.2 ± 0.38
Basal Forebrain6.67 ± 0.26
Basal Part of Pons5.88 ± 0.47
Cerebellar Cortex6.99 ± 0.42
Cerebellar Nuclei5.92 ± 0.38
Claustrum6.12 ± 0.73
Epithalamus7.67 ± 0.61
Frontal Lobe6.16 ± 0.59
Globus Pallidus6.28 ± 0.42
Hypothalamus6.43 ± 0.51
Insula6.4 ± 0.44
Limbic Lobe6.04 ± 0.59
Mesencephalon6.41 ± 0.62
Myelencephalon6.41 ± 0.65
Occipital Lobe6.8 ± 0.65
Parietal Lobe6.24 ± 0.59
Pontine Tegmentum6.23 ± 0.56
Striatum6.13 ± 0.51
Subthalamus5.73 ± 0.82
Temporal Lobe6.32 ± 0.49
Thalamus6.46 ± 0.6
White Matter5.28 ± 0.34
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Plxnb2CBCerebellum67.15
67.28
Plxnb2CTXCerebral cortex38.63
25.38
Plxnb2HIPHippocampal region49
46.64
Plxnb2HPFHippocampal formation44.57
37.74
Plxnb2HYHypothalamus66.93
50.97
Plxnb2LSXLateral septal complex67.56
67.27
Plxnb2MBMidbrain41.73
28.91
Plxnb2MYMedulla44.33
36.33
Plxnb2OLFOlfactory bulb66.93
43.06
Plxnb2PPons32.88
24.34
Plxnb2PALPallidum42.79
28.36
Plxnb2RHPRetrohippocampal region37.57
26.2
Plxnb2sAMYStriatum-like amygdalar nuclei58.58
36.4
Plxnb2STRStriatum33.38
23.13
Plxnb2STRdStriatum dorsal region16.88
12.47
Plxnb2STRvStriatum ventral region52.98
27.74
Plxnb2THThalamus35.43
25.91
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00002399 15 942 956 FGAQLQCVTGPQATR Peptide Atlas
PLXB2_HUMAN_1122 15 1122 1136 AMTLQEAEAFVGAER PRIDE
PLXB2_HUMAN_1761 19 1761 1779 QMVQVSDQDMNTHLAEISR PRIDE
PLXB2_HUMAN_709 16 709 724 FMEPVTMQESGTFAFR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved