AutismKB 2.0

Annotation Detail for SLC7A11


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Basic Information Top
Gene Symbol:SLC7A11 ( CCBR1,xCT )
Gene Full Name: solute carrier family 7, (cationic amino acid transporter, y+ system) member 11
Band: 4q28.3
Quick LinksEntrez ID:23657; OMIM: 607933; Uniprot ID:XCT_HUMAN; ENSEMBL ID: ENSG00000151012; HGNC ID: 11059
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body6 / 7076184
blastocyst1 / 6231916
fetus5 / 5640128
neonate3 / 3109796
infant1 / 2362042
juvenile2 / 5555635
adult91 / 193912146
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor5 / 34366145
chondrosarcoma1 / 8282312
colorectal tumor4 / 11424635
esophageal tumor3 / 17290173
gastrointestinal tumor33 / 119369276
germ cell tumor9 / 26384534
glioma6 / 10688356
head and neck tumor4 / 13630229
kidney tumor2 / 6895929
leukemia5 / 9584252
liver tumor8 / 9635983
lung tumor4 / 10312738
lymphoma2 / 7175527
non-neoplasia6 / 9725061
normal96 / 336030728
ovarian tumor1 / 7668213
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer7 / 10268068
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites2 / 4001549
bladder1 / 2975733
blood8 / 12347864
bone0 / 716550 
bone marrow3 / 4880161
brain41 / 110098937
cervix5 / 48171103
connective tissue10 / 14925566
ear2 / 16212123
embryonic tissue8 / 21572237
esophagus3 / 20209148
eye4 / 21105418
heart0 / 896260 
intestine6 / 23447225
kidney4 / 21177718
larynx0 / 241450 
liver9 / 20774343
lung12 / 33697435
lymph2 / 4427045
lymph node0 / 916100 
mammary gland8 / 15327152
mouth4 / 6705259
muscle6 / 10771555
nerve0 / 157680 
ovary1 / 1020519
pancreas2 / 2148129
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta1 / 2808253
prostate8 / 18934542
salivary gland0 / 201550 
skin9 / 21057442
spleen0 / 539520 
stomach30 / 96619310
testis3 / 3304429
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus2 / 2328788
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209921_at
Cell line Expression level Expression bar
721_B_lymphoblasts294.3
Adipocyte7.25
AdrenalCortex8.4
Adrenalgland6.25
Amygdala216.9
Appendix8.15
AtrioventricularNode8.45
BDCA4+_DentriticCells69.85
Bonemarrow7.25
BronchialEpithelialCells161.65
CD105+_Endothelial10.8
CD14+_Monocytes6.95
CD19+_BCells(neg._sel.)7.5
CD33+_Myeloid8.2
CD34+8.35
CD4+_Tcells7.25
CD56+_NKCells8
CD71+_EarlyErythroid6.2
CD8+_Tcells6.25
CardiacMyocytes596.05
Caudatenucleus62.25
Cerebellum6.15
CerebellumPeduncles15.95
CiliaryGanglion11.85
CingulateCortex28.75
Colorectaladenocarcinoma9
DorsalRootGanglion6.55
FetalThyroid7.3
Fetalbrain17.6
Fetalliver6.05
Fetallung9.2
GlobusPallidus25.55
Heart10.9
Hypothalamus214.55
Kidney5.85
Leukemia_chronicMyelogenousK-56245.2
Leukemia_promyelocytic-HL-60133.05
Leukemialymphoblastic(MOLT-4)15.2
Liver9.75
Lung7.55
Lymphnode5.9
Lymphoma_burkitts(Daudi)113.55
Lymphoma_burkitts(Raji)268.9
MedullaOblongata21.75
OccipitalLobe106.05
OlfactoryBulb39
Ovary5.45
Pancreas66.6
PancreaticIslet8.1
ParietalLobe28.15
Pituitary8
Placenta6.65
Pons14.65
PrefrontalCortex155.6
Prostate8.7
Salivarygland6
SkeletalMuscle9.65
Skin6.45
SmoothMuscle266.45
Spinalcord250.7
SubthalamicNucleus20.8
SuperiorCervicalGanglion12.05
TemporalLobe14.3
Testis5.7
TestisGermCell5.8
TestisIntersitial5.8
TestisLeydigCell6.8
TestisSeminiferousTubule6.05
Thalamus36.35
Thymus5.4
Thyroid9.5
Tongue8.3
Tonsil7.15
Trachea5.95
TrigeminalGanglion9.7
Uterus5.3
UterusCorpus7.3
WholeBlood7.25
Wholebrain32.3
colon6.65
pineal_day77.04
pineal_night67.4
retina200.6
small_intestine6.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P165477
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.62 ± 0.53
Basal Forebrain5.65 ± 0.27
Basal Part of Pons4.27 ± 0.73
Cerebellar Cortex4.37 ± 0.48
Cerebellar Nuclei3.79 ± 0.76
Claustrum4.86 ± 0.79
Epithalamus6.27 ± 0.54
Frontal Lobe5.1 ± 0.64
Globus Pallidus6.28 ± 0.36
Hypothalamus5.48 ± 0.68
Insula5.06 ± 0.46
Limbic Lobe5 ± 0.75
Mesencephalon5.34 ± 0.73
Myelencephalon5.23 ± 0.76
Occipital Lobe5.02 ± 0.51
Parietal Lobe5.16 ± 0.77
Pontine Tegmentum5.22 ± 0.54
Striatum6.02 ± 0.36
Subthalamus4.39 ± 0.18
Temporal Lobe5.01 ± 0.56
Thalamus5.4 ± 0.53
White Matter3.63 ± 0.42
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Slc7a11CBCerebellum9.3
21.24
Slc7a11CTXCerebral cortex12.66
11.79
Slc7a11HIPHippocampal region13.56
22.91
Slc7a11HPFHippocampal formation14.75
21.11
Slc7a11HYHypothalamus9.63
9.89
Slc7a11LSXLateral septal complex8.79
8.73
Slc7a11MBMidbrain11.27
18.98
Slc7a11MYMedulla6.06
10.66
Slc7a11OLFOlfactory bulb15.57
15.67
Slc7a11PPons6.16
9.99
Slc7a11PALPallidum8.65
9.07
Slc7a11RHPRetrohippocampal region16.05
17.69
Slc7a11sAMYStriatum-like amygdalar nuclei16.46
15.21
Slc7a11STRStriatum7.67
7.66
Slc7a11STRdStriatum dorsal region5.87
6.4
Slc7a11STRvStriatum ventral region8.57
7.13
Slc7a11THThalamus12.77
18
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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