AutismKB 2.0

Annotation Detail for PPIL2


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Basic Information Top
Gene Symbol:PPIL2 ( CYC4,CYP60,Cyp-60,FLJ39930,MGC33174,MGC787,hCyP-60 )
Gene Full Name: peptidylprolyl isomerase (cyclophilin)-like 2
Band: 22q11.21
Quick LinksEntrez ID:23759; OMIM: 607588; Uniprot ID:PPIL2_HUMAN; ENSEMBL ID: ENSG00000100023; HGNC ID: 9261
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst5 / 6231980
fetus55 / 56401297
neonate7 / 31097225
infant0 / 236200 
juvenile10 / 55556179
adult170 / 193912187
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor2 / 9417821
cervical tumor3 / 3436687
chondrosarcoma4 / 8282348
colorectal tumor5 / 11424643
esophageal tumor1 / 1729057
gastrointestinal tumor18 / 119369150
germ cell tumor29 / 263845109
glioma15 / 106883140
head and neck tumor19 / 136302139
kidney tumor4 / 6895958
leukemia7 / 9584273
liver tumor4 / 9635941
lung tumor8 / 10312777
lymphoma13 / 71755181
non-neoplasia2 / 9725020
normal279 / 336030783
ovarian tumor1 / 7668213
pancreatic tumor17 / 104616162
primitive neuroectodermal tumor of the CNS36 / 125680286
prostate cancer6 / 10268058
retinoblastoma4 / 4635686
skin tumor9 / 12494972
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites4 / 4001599
bladder1 / 2975733
blood8 / 12347864
bone3 / 7165541
bone marrow8 / 48801163
brain120 / 1100989108
cervix3 / 4817162
connective tissue4 / 14925526
ear0 / 162120 
embryonic tissue11 / 21572250
esophagus1 / 2020949
eye25 / 211054118
heart5 / 8962655
intestine14 / 23447259
kidney10 / 21177747
larynx0 / 241450 
liver8 / 20774338
lung24 / 33697471
lymph3 / 4427067
lymph node12 / 91610130
mammary gland12 / 15327178
mouth8 / 67052119
muscle12 / 107715111
nerve1 / 1576863
ovary1 / 1020519
pancreas23 / 214812107
parathyroid2 / 2053997
pharynx7 / 41328169
pituitary gland0 / 165850 
placenta22 / 28082578
prostate20 / 189345105
salivary gland5 / 20155248
skin12 / 21057456
spleen7 / 53952129
stomach17 / 96619175
testis27 / 33044281
thymus11 / 81131135
thyroid0 / 474730 
tonsil0 / 169990 
trachea8 / 52413152
umbilical cord9 / 13680657
uterus22 / 23287894
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209299_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts10.3
Adipocyte3.7
AdrenalCortex3.8
Adrenalgland3.15
Amygdala4
Appendix3.65
AtrioventricularNode2.8
BDCA4+_DentriticCells9.95
Bonemarrow3.75
BronchialEpithelialCells3.55
CD105+_Endothelial3.8
CD14+_Monocytes5.75
CD19+_BCells(neg._sel.)4.6
CD33+_Myeloid4.8
CD34+9.05
CD4+_Tcells22.75
CD56+_NKCells8.75
CD71+_EarlyErythroid4.95
CD8+_Tcells11.2
CardiacMyocytes4.6
Caudatenucleus3.35
Cerebellum2.95
CerebellumPeduncles4.15
CiliaryGanglion2.55
CingulateCortex3.8
Colorectaladenocarcinoma4.05
DorsalRootGanglion2.75
FetalThyroid5.35
Fetalbrain9.6
Fetalliver3.15
Fetallung3.1
GlobusPallidus2.7
Heart5.15
Hypothalamus4.05
Kidney2.95
Leukemia_chronicMyelogenousK-56227.5
Leukemia_promyelocytic-HL-603.65
Leukemialymphoblastic(MOLT-4)6.6
Liver4.85
Lung4.25
Lymphnode4.5
Lymphoma_burkitts(Daudi)12.4
Lymphoma_burkitts(Raji)5.15
MedullaOblongata3.4
OccipitalLobe3.3
OlfactoryBulb2.95
Ovary2.45
Pancreas2.95
PancreaticIslet3.95
ParietalLobe3.85
Pituitary4.4
Placenta5.15
Pons3.5
PrefrontalCortex4.55
Prostate4.8
Salivarygland2.85
SkeletalMuscle4.15
Skin2.8
SmoothMuscle5.2
Spinalcord3.95
SubthalamicNucleus3.3
SuperiorCervicalGanglion4.1
TemporalLobe3.4
Testis3.15
TestisGermCell3.15
TestisIntersitial3.05
TestisLeydigCell3.65
TestisSeminiferousTubule3.2
Thalamus3.75
Thymus4.15
Thyroid5.65
Tongue3.55
Tonsil3.6
Trachea3.1
TrigeminalGanglion3.6
Uterus3.1
UterusCorpus3.3
WholeBlood3.95
Wholebrain3.25
colon3.75
pineal_day5.22
pineal_night4.6
retina4.45
small_intestine3.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P284783
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.08 ± 0.34
Basal Forebrain4.44 ± 0.2
Basal Part of Pons5.04 ± 0.43
Cerebellar Cortex4.6 ± 0.38
Cerebellar Nuclei4.72 ± 0.49
Claustrum5.14 ± 0.53
Epithalamus4.65 ± 0.26
Frontal Lobe4.78 ± 0.39
Globus Pallidus4.88 ± 0.68
Hypothalamus4.69 ± 0.36
Insula4.95 ± 0.3
Limbic Lobe5.02 ± 0.44
Mesencephalon4.78 ± 0.47
Myelencephalon4.82 ± 0.47
Occipital Lobe4.91 ± 0.38
Parietal Lobe4.82 ± 0.46
Pontine Tegmentum4.87 ± 0.51
Striatum4.71 ± 0.48
Subthalamus4.43 ± 0.03
Temporal Lobe5.07 ± 0.43
Thalamus4.76 ± 0.42
White Matter5.6 ± 0.28
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ppil2CBCerebellum30.14
38.08
Ppil2CTXCerebral cortex73.16
60.49
Ppil2HIPHippocampal region54.18
84.18
Ppil2HPFHippocampal formation55.1
67.05
Ppil2HYHypothalamus42.8
35.95
Ppil2LSXLateral septal complex78.97
59.95
Ppil2MBMidbrain35.16
31.42
Ppil2MYMedulla39.28
43.32
Ppil2OLFOlfactory bulb72.98
68.77
Ppil2PPons33.97
36.55
Ppil2PALPallidum42.05
37.99
Ppil2RHPRetrohippocampal region57.14
47.75
Ppil2sAMYStriatum-like amygdalar nuclei38.1
28.22
Ppil2STRStriatum45.75
34.32
Ppil2STRdStriatum dorsal region38.13
27.69
Ppil2STRvStriatum ventral region65.77
51.49
Ppil2THThalamus48.14
42.16
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00004983 19 284 302 LHTNKGDLNLELHCDLTPK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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