AutismKB 2.0

Annotation Detail for ARHGAP8


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Basic Information Top
Gene Symbol:ARHGAP8 ( BPGAP1,FLJ20185,PP610 )
Gene Full Name: Rho GTPase activating protein 8
Band: 22q13.31
Quick LinksEntrez ID:23779; OMIM: 609405; Uniprot ID:RHG08_HUMAN; ENSEMBL ID: ENSG00000241484; HGNC ID: 677
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Microarray in BioGPS Top
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  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205980_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.2
Adipocyte4.2
AdrenalCortex4.8
Adrenalgland3.7
Amygdala4.4
Appendix4.75
AtrioventricularNode3.55
BDCA4+_DentriticCells4.55
Bonemarrow4.4
BronchialEpithelialCells4.95
CD105+_Endothelial4.4
CD14+_Monocytes4.6
CD19+_BCells(neg._sel.)4.5
CD33+_Myeloid5.6
CD34+5.6
CD4+_Tcells4.55
CD56+_NKCells5.3
CD71+_EarlyErythroid4.1
CD8+_Tcells4.1
CardiacMyocytes6.3
Caudatenucleus3.9
Cerebellum3.55
CerebellumPeduncles5
CiliaryGanglion3.4
CingulateCortex4.55
Colorectaladenocarcinoma4.65
DorsalRootGanglion3.6
FetalThyroid4.8
Fetalbrain4.3
Fetalliver3.75
Fetallung3.7
GlobusPallidus3.3
Heart5.9
Hypothalamus4.6
Kidney3.7
Leukemia_chronicMyelogenousK-5623.95
Leukemia_promyelocytic-HL-603.85
Leukemialymphoblastic(MOLT-4)3.4
Liver6.15
Lung7.7
Lymphnode3.65
Lymphoma_burkitts(Daudi)5.65
Lymphoma_burkitts(Raji)6.55
MedullaOblongata3.9
OccipitalLobe3.85
OlfactoryBulb3.45
Ovary3.05
Pancreas3.55
PancreaticIslet4.7
ParietalLobe4.65
Pituitary5.05
Placenta19.5
Pons4.1
PrefrontalCortex5.25
Prostate28.05
Salivarygland3.65
SkeletalMuscle5.6
Skin3.5
SmoothMuscle4.85
Spinalcord4.55
SubthalamicNucleus4
SuperiorCervicalGanglion5.5
TemporalLobe3.95
Testis3.7
TestisGermCell3.65
TestisIntersitial3.65
TestisLeydigCell4.6
TestisSeminiferousTubule3.7
Thalamus4.45
Thymus3.3
Thyroid31.1
Tongue4.5
Tonsil4.25
Trachea3.6
TrigeminalGanglion4.75
Uterus3.55
UterusCorpus4.05
WholeBlood4.7
Wholebrain3.55
colon24.9
pineal_day5.38
pineal_night5.26
retina5.275
small_intestine4.25
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P85117
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.05 ± 0.98
Basal Forebrain1.65 ± 0.19
Basal Part of Pons1.24 ± 0.34
Cerebellar Cortex1.48 ± 0.71
Cerebellar Nuclei1.94 ± 0.74
Claustrum2.5 ± 0.84
Epithalamus1.35 ± 0.74
Frontal Lobe1.46 ± 0.59
Globus Pallidus2.25 ± 0.33
Hypothalamus1.67 ± 0.65
Insula1.79 ± 0.93
Limbic Lobe1.63 ± 0.59
Mesencephalon1.76 ± 0.65
Myelencephalon1.64 ± 0.62
Occipital Lobe1.69 ± 0.66
Parietal Lobe1.61 ± 0.65
Pontine Tegmentum1.71 ± 0.65
Striatum1.8 ± 0.52
Subthalamus1.82 ± 0.63
Temporal Lobe1.49 ± 0.53
Thalamus1.61 ± 0.56
White Matter2.19 ± 0.44
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
3110043J09RikCBCerebellum1.28
1.46
3110043J09RikCTXCerebral cortex1.86
1.46
3110043J09RikHIPHippocampal region1.6
1.37
3110043J09RikHPFHippocampal formation1.24
1.02
3110043J09RikHYHypothalamus0.42
0.46
3110043J09RikLSXLateral septal complex0.06
0.17
3110043J09RikMBMidbrain0.26
0.47
3110043J09RikMYMedulla2.39
2.46
3110043J09RikOLFOlfactory bulb12.74
11.09
3110043J09RikPPons1.92
2.83
3110043J09RikPALPallidum0.12
0.08
3110043J09RikRHPRetrohippocampal region0.49
0.43
3110043J09RiksAMYStriatum-like amygdalar nuclei1.32
0.93
3110043J09RikSTRStriatum0.82
0.68
3110043J09RikSTRdStriatum dorsal region0.39
0.44
3110043J09RikSTRvStriatum ventral region2.99
1.96
3110043J09RikTHThalamus0.09
0.34
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018