AutismKB 2.0

Annotation Detail for ALOX5AP


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Basic Information Top
Gene Symbol:ALOX5AP ( FLAP )
Gene Full Name: arachidonate 5-lipoxygenase-activating protein
Band: 13q12.3
Quick LinksEntrez ID:241; OMIM: 603700; Uniprot ID:AL5AP_HUMAN; ENSEMBL ID: ENSG00000132965; HGNC ID: 436
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus8 / 56401214
neonate1 / 3109732
infant0 / 236200 
juvenile3 / 5555653
adult104 / 193912153
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma8 / 8282396
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor1 / 2638453
glioma1 / 1068839
head and neck tumor2 / 13630214
kidney tumor1 / 6895914
leukemia21 / 95842219
liver tumor2 / 9635920
lung tumor0 / 1031270 
lymphoma2 / 7175527
non-neoplasia1 / 9725010
normal135 / 336030740
ovarian tumor1 / 7668213
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood27 / 123478218
bone0 / 716550 
bone marrow4 / 4880181
brain6 / 11009895
cervix0 / 481710 
connective tissue9 / 14925560
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye10 / 21105447
heart0 / 896260 
intestine4 / 23447217
kidney4 / 21177718
larynx0 / 241450 
liver4 / 20774319
lung23 / 33697468
lymph2 / 4427045
lymph node1 / 9161010
mammary gland1 / 1532716
mouth1 / 6705214
muscle0 / 1077150 
nerve0 / 157680 
ovary2 / 10205119
pancreas11 / 21481251
parathyroid0 / 205390 
pharynx10 / 41328241
pituitary gland0 / 165850 
placenta7 / 28082524
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach2 / 9661920
testis3 / 3304429
thymus0 / 811310 
thyroid2 / 4747342
tonsil1 / 1699958
trachea0 / 524130 
umbilical cord1 / 1368073
uterus2 / 2328788
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204174_at
Cell line Expression level Expression bar
721_B_lymphoblasts269.7
Adipocyte5.6
AdrenalCortex5.85
Adrenalgland5.3
Amygdala8.05
Appendix5.55
AtrioventricularNode4.6
BDCA4+_DentriticCells2744.9
Bonemarrow1461.25
BronchialEpithelialCells7.65
CD105+_Endothelial5.55
CD14+_Monocytes384.25
CD19+_BCells(neg._sel.)591.75
CD33+_Myeloid765.6
CD34+68.35
CD4+_Tcells362.45
CD56+_NKCells666.3
CD71+_EarlyErythroid5.3
CD8+_Tcells319.8
CardiacMyocytes7.1
Caudatenucleus6.9
Cerebellum4.55
CerebellumPeduncles6.55
CiliaryGanglion3.95
CingulateCortex5.6
Colorectaladenocarcinoma5.55
DorsalRootGanglion4.25
FetalThyroid5.45
Fetalbrain6.4
Fetalliver4.8
Fetallung26.5
GlobusPallidus4.05
Heart8.8
Hypothalamus23
Kidney4.45
Leukemia_chronicMyelogenousK-5625.2
Leukemia_promyelocytic-HL-60145.25
Leukemialymphoblastic(MOLT-4)8.2
Liver7.85
Lung534.8
Lymphnode82.75
Lymphoma_burkitts(Daudi)291.85
Lymphoma_burkitts(Raji)496.3
MedullaOblongata5.15
OccipitalLobe5.15
OlfactoryBulb8.5
Ovary4.15
Pancreas4.5
PancreaticIslet18.95
ParietalLobe6.3
Pituitary7.35
Placenta22.85
Pons5.25
PrefrontalCortex6.5
Prostate6.55
Salivarygland22.8
SkeletalMuscle6.35
Skin4.3
SmoothMuscle6.45
Spinalcord20.05
SubthalamicNucleus5.2
SuperiorCervicalGanglion6.7
TemporalLobe5.35
Testis4.75
TestisGermCell4.5
TestisIntersitial4.7
TestisLeydigCell5.45
TestisSeminiferousTubule4.7
Thalamus12
Thymus181.7
Thyroid7.15
Tongue5.5
Tonsil88.95
Trachea6.15
TrigeminalGanglion5.95
Uterus5.05
UterusCorpus5.15
WholeBlood1715.6
Wholebrain4.85
colon5.7
pineal_day7.04
pineal_night6.66
retina18.625
small_intestine13.9
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P2793
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.97 ± 0.57
Basal Forebrain6.15 ± 0.64
Basal Part of Pons7.19 ± 0.35
Cerebellar Cortex5.54 ± 0.4
Cerebellar Nuclei7.96 ± 0.49
Claustrum5.82 ± 0.8
Epithalamus7.3 ± 0.59
Frontal Lobe6.07 ± 0.72
Globus Pallidus8.09 ± 0.54
Hypothalamus6.41 ± 1.1
Insula6.26 ± 0.49
Limbic Lobe5.91 ± 0.69
Mesencephalon6.02 ± 0.88
Myelencephalon6.17 ± 0.82
Occipital Lobe5.48 ± 0.79
Parietal Lobe6.1 ± 0.77
Pontine Tegmentum5.95 ± 0.7
Striatum6.63 ± 0.6
Subthalamus7.12 ± 0.14
Temporal Lobe6.3 ± 0.76
Thalamus6.14 ± 0.51
White Matter7.72 ± 0.49
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Alox5apCBCerebellum24.69
32.55
Alox5apCTXCerebral cortex8.13
5.84
Alox5apHIPHippocampal region11.66
11.7
Alox5apHPFHippocampal formation11.34
10.35
Alox5apHYHypothalamus2.69
2.09
Alox5apLSXLateral septal complex1.36
1.28
Alox5apMBMidbrain3.92
4.06
Alox5apMYMedulla8.32
9.38
Alox5apOLFOlfactory bulb25.73
20.41
Alox5apPPons5.7
8.19
Alox5apPALPallidum3.34
2.85
Alox5apRHPRetrohippocampal region10.5
8.07
Alox5apsAMYStriatum-like amygdalar nuclei11.38
8.34
Alox5apSTRStriatum4.85
3.64
Alox5apSTRdStriatum dorsal region3.6
2.83
Alox5apSTRvStriatum ventral region7
4.74
Alox5apTHThalamus7.56
6.08
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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