AutismKB 2.0

Annotation Detail for ALOX12B


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Basic Information Top
Gene Symbol:ALOX12B ( 12R-LOX )
Gene Full Name: arachidonate 12-lipoxygenase, 12R type
Band: 17p13.1
Quick LinksEntrez ID:242; OMIM: 603741; Uniprot ID:LX12B_HUMAN; ENSEMBL ID: ENSG00000179477; HGNC ID: 430
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus2 / 5640123
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult2 / 19391211
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor0 / 941780 
cervical tumor1 / 3436629
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma1 / 1068839
head and neck tumor1 / 1363027
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor1 / 1031279
lymphoma1 / 7175513
non-neoplasia0 / 972500 
normal18 / 33603075
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder1 / 2975733
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain6 / 11009895
cervix1 / 4817120
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye2 / 2110549
heart0 / 896260 
intestine0 / 2344720 
kidney0 / 2117770 
larynx0 / 241450 
liver0 / 2077430 
lung1 / 3369742
lymph1 / 4427022
lymph node2 / 9161021
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin9 / 21057442
spleen0 / 539520 
stomach0 / 966190 
testis0 / 3304420 
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 207381_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.5
Adipocyte4.2
AdrenalCortex4.6
Adrenalgland3.6
Amygdala4.35
Appendix4.3
AtrioventricularNode3.35
BDCA4+_DentriticCells4.55
Bonemarrow4.25
BronchialEpithelialCells4.2
CD105+_Endothelial4.25
CD14+_Monocytes4.45
CD19+_BCells(neg._sel.)4.55
CD33+_Myeloid5.45
CD34+5.35
CD4+_Tcells4.55
CD56+_NKCells4.95
CD71+_EarlyErythroid4
CD8+_Tcells4.05
CardiacMyocytes5.65
Caudatenucleus3.8
Cerebellum3.45
CerebellumPeduncles4.8
CiliaryGanglion3.1
CingulateCortex4.35
Colorectaladenocarcinoma4.25
DorsalRootGanglion3.35
FetalThyroid4.1
Fetalbrain4.25
Fetalliver3.7
Fetallung3.45
GlobusPallidus3.2
Heart5.5
Hypothalamus4.6
Kidney3.5
Leukemia_chronicMyelogenousK-5623.85
Leukemia_promyelocytic-HL-603.75
Leukemialymphoblastic(MOLT-4)3.45
Liver5.7
Lung4.65
Lymphnode3.6
Lymphoma_burkitts(Daudi)5.4
Lymphoma_burkitts(Raji)6
MedullaOblongata3.9
OccipitalLobe3.8
OlfactoryBulb3.35
Ovary2.8
Pancreas3.4
PancreaticIslet4.5
ParietalLobe4.5
Pituitary4.95
Placenta4.35
Pons4
PrefrontalCortex5.25
Prostate4.95
Salivarygland3.4
SkeletalMuscle5.05
Skin3.55
SmoothMuscle4.8
Spinalcord4.55
SubthalamicNucleus3.9
SuperiorCervicalGanglion5
TemporalLobe3.9
Testis3.65
TestisGermCell3.6
TestisIntersitial3.55
TestisLeydigCell4.2
TestisSeminiferousTubule3.6
Thalamus4.35
Thymus3.35
Thyroid5.25
Tongue4.25
Tonsil6.1
Trachea3.55
TrigeminalGanglion4.4
Uterus3.4
UterusCorpus3.8
WholeBlood4.65
Wholebrain3.55
colon4.25
pineal_day5.28
pineal_night5.18
retina5.125
small_intestine4.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P83634
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.56 ± 0.72
Basal Forebrain3.52 ± 0.29
Basal Part of Pons3.35 ± 0.5
Cerebellar Cortex3.22 ± 0.65
Cerebellar Nuclei3.37 ± 0.53
Claustrum3.87 ± 0.89
Epithalamus2.8 ± 0.39
Frontal Lobe3.26 ± 0.56
Globus Pallidus3.17 ± 0.69
Hypothalamus3.08 ± 0.62
Insula3.26 ± 0.36
Limbic Lobe3.3 ± 0.66
Mesencephalon3.49 ± 0.65
Myelencephalon3.37 ± 0.64
Occipital Lobe3.3 ± 0.8
Parietal Lobe3.41 ± 0.49
Pontine Tegmentum3.19 ± 0.58
Striatum3.16 ± 0.67
Subthalamus3.3 ± 0.36
Temporal Lobe3.31 ± 0.58
Thalamus3.4 ± 0.53
White Matter3.31 ± 0.62
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Alox12bCBCerebellum3.33
4.65
Alox12bCTXCerebral cortex0.91
0.81
Alox12bHIPHippocampal region2.97
3.23
Alox12bHPFHippocampal formation2.28
2.22
Alox12bHYHypothalamus0.14
0.25
Alox12bLSXLateral septal complex0.04
0
Alox12bMBMidbrain1.27
1.18
Alox12bMYMedulla7.49
7.94
Alox12bOLFOlfactory bulb0.88
1.22
Alox12bPPons2.62
2.58
Alox12bPALPallidum0.08
0.11
Alox12bRHPRetrohippocampal region1.16
0.83
Alox12bsAMYStriatum-like amygdalar nuclei0.16
0.2
Alox12bSTRStriatum0.09
0.13
Alox12bSTRdStriatum dorsal region0.07
0.11
Alox12bSTRvStriatum ventral region0.14
0.19
Alox12bTHThalamus0.32
0.44
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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