AutismKB 2.0

Annotation Detail for FRK


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Basic Information Top
Gene Symbol:FRK ( GTK,PTK5,RAK )
Gene Full Name: fyn-related kinase
Band: 6q22.1
Quick LinksEntrez ID:2444; OMIM: 606573; Uniprot ID:FRK_HUMAN; ENSEMBL ID: ENSG00000111816; HGNC ID: 3955
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus1 / 5640121
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult10 / 19391215
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor3 / 13630222
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal8 / 33603072
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites2 / 4001549
bladder3 / 29757100
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain0 / 11009890 
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine0 / 2344720 
kidney0 / 2117770 
larynx1 / 2414541
liver2 / 2077439
lung0 / 3369740 
lymph0 / 442700 
lymph node0 / 916100 
mammary gland2 / 15327113
mouth2 / 6705229
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta1 / 2808253
prostate2 / 18934510
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis6 / 33044218
thymus1 / 8113112
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 207178_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.3
Adipocyte6.7
AdrenalCortex8.85
Adrenalgland6.05
Amygdala6.8
Appendix9
AtrioventricularNode6.95
BDCA4+_DentriticCells7.4
Bonemarrow7.55
BronchialEpithelialCells6.55
CD105+_Endothelial6.85
CD14+_Monocytes7.45
CD19+_BCells(neg._sel.)7.05
CD33+_Myeloid9.1
CD34+8.55
CD4+_Tcells7.1
CD56+_NKCells7.8
CD71+_EarlyErythroid6.65
CD8+_Tcells6.15
CardiacMyocytes11.8
Caudatenucleus6.15
Cerebellum5.6
CerebellumPeduncles8.4
CiliaryGanglion7.05
CingulateCortex7.3
Colorectaladenocarcinoma6.9
DorsalRootGanglion6.95
FetalThyroid6.85
Fetalbrain6.5
Fetalliver5.95
Fetallung5.35
GlobusPallidus5.55
Heart11.15
Hypothalamus7.4
Kidney6.3
Leukemia_chronicMyelogenousK-5626.15
Leukemia_promyelocytic-HL-606.05
Leukemialymphoblastic(MOLT-4)5.25
Liver10.95
Lung7.55
Lymphnode5.55
Lymphoma_burkitts(Daudi)9.15
Lymphoma_burkitts(Raji)10.8
MedullaOblongata6.25
OccipitalLobe6.05
OlfactoryBulb5.3
Ovary5.75
Pancreas5.8
PancreaticIslet7.6
ParietalLobe7.85
Pituitary7.95
Placenta6.75
Pons6.9
PrefrontalCortex8.05
Prostate7.75
Salivarygland5.8
SkeletalMuscle10.25
Skin6.65
SmoothMuscle7.7
Spinalcord7.25
SubthalamicNucleus6.6
SuperiorCervicalGanglion14.6
TemporalLobe6.45
Testis5.85
TestisGermCell5.45
TestisIntersitial6.15
TestisLeydigCell7.1
TestisSeminiferousTubule5.9
Thalamus7.2
Thymus5.1
Thyroid8.2
Tongue7.65
Tonsil6.8
Trachea5.65
TrigeminalGanglion11.15
Uterus5.4
UterusCorpus7.35
WholeBlood7.45
Wholebrain5.4
colon6.95
pineal_day8.3
pineal_night8.16
retina8.325
small_intestine6.65
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_15200_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.51 ± 0.98
Basal Forebrain3.06 ± 0.29
Basal Part of Pons3.22 ± 0.76
Cerebellar Cortex2.6 ± 0.42
Cerebellar Nuclei4.04 ± 0.91
Claustrum3.21 ± 0.73
Epithalamus3.87 ± 0.74
Frontal Lobe3.75 ± 0.73
Globus Pallidus4.67 ± 0.29
Hypothalamus3.06 ± 0.55
Insula2.43 ± 0.8
Limbic Lobe3.34 ± 0.87
Mesencephalon3.56 ± 1.03
Myelencephalon3.36 ± 0.83
Occipital Lobe3.29 ± 0.97
Parietal Lobe3.27 ± 0.94
Pontine Tegmentum3.64 ± 0.83
Striatum4.76 ± 0.46
Subthalamus3.84 ± 0.34
Temporal Lobe3 ± 0.76
Thalamus3.26 ± 0.67
White Matter5.93 ± 0.14
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
FrkCBCerebellum0.13
0.26
FrkCTXCerebral cortex0.69
0.7
FrkHIPHippocampal region1.06
0.93
FrkHPFHippocampal formation0.7
0.59
FrkHYHypothalamus0.31
0.52
FrkLSXLateral septal complex2.72
2.48
FrkMBMidbrain0.15
0.46
FrkMYMedulla0
0
FrkOLFOlfactory bulb0.19
0.18
FrkPPons0.07
0.28
FrkPALPallidum0.06
0.16
FrkRHPRetrohippocampal region0.23
0.21
FrksAMYStriatum-like amygdalar nuclei0.42
1.59
FrkSTRStriatum0.21
0.49
FrkSTRdStriatum dorsal region0.12
0.41
FrkSTRvStriatum ventral region0.16
0.13
FrkTHThalamus0.08
0.08
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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