AutismKB 2.0

Annotation Detail for CNOT6L


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Basic Information Top
Gene Symbol:CNOT6L ( CCR4b )
Gene Full Name: CCR4-NOT transcription complex, subunit 6-like
Band: 4q21.1
Quick LinksEntrez ID:246175; OMIM: NA; Uniprot ID:CNO6L_HUMAN; ENSEMBL ID: ENSG00000138767; HGNC ID: 18042
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst1 / 6231916
fetus31 / 56401254
neonate0 / 310970 
infant1 / 2362042
juvenile1 / 5555617
adult56 / 193912128
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor5 / 12794390
bladder carcinoma3 / 17475171
breast (mammary gland) tumor8 / 9417884
cervical tumor0 / 343660 
chondrosarcoma2 / 8282324
colorectal tumor1 / 1142468
esophageal tumor1 / 1729057
gastrointestinal tumor0 / 1193690 
germ cell tumor5 / 26384518
glioma2 / 10688318
head and neck tumor0 / 1363020 
kidney tumor2 / 6895929
leukemia1 / 9584210
liver tumor2 / 9635920
lung tumor0 / 1031270 
lymphoma1 / 7175513
non-neoplasia3 / 9725030
normal123 / 336030736
ovarian tumor1 / 7668213
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer2 / 10268019
retinoblastoma1 / 4635621
skin tumor2 / 12494916
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland5 / 33197150
ascites0 / 400150 
bladder3 / 29757100
blood3 / 12347824
bone1 / 7165513
bone marrow1 / 4880120
brain33 / 110098929
cervix3 / 4817162
connective tissue2 / 14925513
ear2 / 16212123
embryonic tissue7 / 21572232
esophagus1 / 2020949
eye6 / 21105428
heart0 / 896260 
intestine6 / 23447225
kidney6 / 21177728
larynx0 / 241450 
liver3 / 20774314
lung7 / 33697420
lymph0 / 442700 
lymph node12 / 91610130
mammary gland10 / 15327165
mouth0 / 670520 
muscle5 / 10771546
nerve2 / 15768126
ovary1 / 1020519
pancreas8 / 21481237
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta13 / 28082546
prostate3 / 18934515
salivary gland0 / 201550 
skin4 / 21057418
spleen7 / 53952129
stomach1 / 9661910
testis6 / 33044218
thymus7 / 8113186
thyroid0 / 474730 
tonsil0 / 169990 
trachea9 / 52413171
umbilical cord0 / 136800 
uterus7 / 23287830
vascular2 / 5178038
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P110304
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.1 ± 0.23
Basal Forebrain8.28 ± 0.15
Basal Part of Pons7.71 ± 0.34
Cerebellar Cortex8.42 ± 0.16
Cerebellar Nuclei8.24 ± 0.23
Claustrum8.06 ± 0.32
Epithalamus8.31 ± 0.19
Frontal Lobe8.01 ± 0.26
Globus Pallidus7.95 ± 0.21
Hypothalamus8.34 ± 0.33
Insula8.1 ± 0.28
Limbic Lobe8.05 ± 0.28
Mesencephalon8.13 ± 0.3
Myelencephalon8.1 ± 0.3
Occipital Lobe8.51 ± 0.18
Parietal Lobe8.21 ± 0.24
Pontine Tegmentum8.23 ± 0.21
Striatum8.01 ± 0.25
Subthalamus8 ± 0.47
Temporal Lobe8.07 ± 0.27
Thalamus8.07 ± 0.2
White Matter8.42 ± 0.13
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Cnot6lCBCerebellum6.93
7.35
Cnot6lCTXCerebral cortex19.44
14.18
Cnot6lHIPHippocampal region30.19
45.62
Cnot6lHPFHippocampal formation28.67
36.56
Cnot6lHYHypothalamus21.39
17.56
Cnot6lLSXLateral septal complex12.62
9.46
Cnot6lMBMidbrain5.15
5.25
Cnot6lMYMedulla3.6
4.39
Cnot6lOLFOlfactory bulb33.47
30.12
Cnot6lPPons6.14
7.01
Cnot6lPALPallidum8.12
7.43
Cnot6lRHPRetrohippocampal region25.98
21.07
Cnot6lsAMYStriatum-like amygdalar nuclei21.98
16.42
Cnot6lSTRStriatum20.16
15.53
Cnot6lSTRdStriatum dorsal region15.7
11.08
Cnot6lSTRvStriatum ventral region37.39
30.61
Cnot6lTHThalamus8
8.04
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018