AutismKB 2.0

Annotation Detail for RNASEH1


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Basic Information Top
Gene Symbol:RNASEH1 ( H1RNA,RNH1 )
Gene Full Name: ribonuclease H1
Band: 2p25.3
Quick LinksEntrez ID:246243; OMIM: 604123; Uniprot ID:RNH1_HUMAN; ENSEMBL ID: ENSG00000171865; HGNC ID: 18466
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst3 / 6231948
fetus15 / 56401226
neonate4 / 31097128
infant2 / 2362084
juvenile8 / 55556143
adult80 / 193912141
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor7 / 9417874
cervical tumor1 / 3436629
chondrosarcoma8 / 8282396
colorectal tumor7 / 11424661
esophageal tumor0 / 172900 
gastrointestinal tumor10 / 11936983
germ cell tumor11 / 26384541
glioma5 / 10688346
head and neck tumor4 / 13630229
kidney tumor2 / 6895929
leukemia7 / 9584273
liver tumor5 / 9635951
lung tumor7 / 10312767
lymphoma2 / 7175527
non-neoplasia3 / 9725030
normal108 / 336030732
ovarian tumor8 / 76682104
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS14 / 125680111
prostate cancer6 / 10268058
retinoblastoma8 / 46356172
skin tumor6 / 12494948
soft tissue/muscle tissue tumor8 / 12519163
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland3 / 3319790
ascites1 / 4001524
bladder1 / 2975733
blood8 / 12347864
bone6 / 7165583
bone marrow2 / 4880140
brain31 / 110098928
cervix1 / 4817120
connective tissue5 / 14925533
ear2 / 16212123
embryonic tissue14 / 21572264
esophagus0 / 202090 
eye10 / 21105447
heart1 / 8962611
intestine10 / 23447242
kidney4 / 21177718
larynx0 / 241450 
liver10 / 20774348
lung14 / 33697441
lymph0 / 442700 
lymph node2 / 9161021
mammary gland9 / 15327158
mouth3 / 6705244
muscle5 / 10771546
nerve0 / 157680 
ovary8 / 10205178
pancreas8 / 21481237
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta9 / 28082532
prostate13 / 18934568
salivary gland0 / 201550 
skin10 / 21057447
spleen1 / 5395218
stomach10 / 96619103
testis8 / 33044224
thymus1 / 8113112
thyroid1 / 4747321
tonsil1 / 1699958
trachea1 / 5241319
umbilical cord4 / 13680292
uterus10 / 23287842
vascular6 / 51780115
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 218497_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts222.4
Adipocyte34.3
AdrenalCortex24.3
Adrenalgland21.4
Amygdala35.45
Appendix27.5
AtrioventricularNode23.9
BDCA4+_DentriticCells98.1
Bonemarrow29.2
BronchialEpithelialCells55.7
CD105+_Endothelial53.3
CD14+_Monocytes40.8
CD19+_BCells(neg._sel.)52.5
CD33+_Myeloid54.15
CD34+52.95
CD4+_Tcells36.5
CD56+_NKCells64.15
CD71+_EarlyErythroid32.1
CD8+_Tcells41.6
CardiacMyocytes52.85
Caudatenucleus20.7
Cerebellum19.2
CerebellumPeduncles32.1
CiliaryGanglion14.65
CingulateCortex23.25
Colorectaladenocarcinoma87.75
DorsalRootGanglion22.05
FetalThyroid26.2
Fetalbrain20.8
Fetalliver23.75
Fetallung20.75
GlobusPallidus20.45
Heart34.55
Hypothalamus29.35
Kidney22.05
Leukemia_chronicMyelogenousK-56237.35
Leukemia_promyelocytic-HL-6045.4
Leukemialymphoblastic(MOLT-4)30.25
Liver29.65
Lung50.25
Lymphnode20.05
Lymphoma_burkitts(Daudi)36.8
Lymphoma_burkitts(Raji)38.7
MedullaOblongata21.5
OccipitalLobe27.3
OlfactoryBulb21.05
Ovary18
Pancreas19.5
PancreaticIslet29.3
ParietalLobe28.8
Pituitary32.05
Placenta31.65
Pons23.45
PrefrontalCortex32.25
Prostate45.4
Salivarygland21.6
SkeletalMuscle27.45
Skin27.85
SmoothMuscle61.9
Spinalcord14.95
SubthalamicNucleus25.1
SuperiorCervicalGanglion31.8
TemporalLobe24.45
Testis19.25
TestisGermCell24.7
TestisIntersitial22.05
TestisLeydigCell24.95
TestisSeminiferousTubule19.9
Thalamus26.95
Thymus24.95
Thyroid38.35
Tongue26.75
Tonsil27.4
Trachea16.15
TrigeminalGanglion30.5
Uterus54.7
UterusCorpus23.9
WholeBlood22.4
Wholebrain51.9
colon28.05
pineal_day27.32
pineal_night29.54
retina41.9
small_intestine36.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_7971_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.15 ± 0.38
Basal Forebrain8.72 ± 0.13
Basal Part of Pons8.52 ± 0.26
Cerebellar Cortex8.5 ± 0.25
Cerebellar Nuclei8.8 ± 0.24
Claustrum9.17 ± 0.55
Epithalamus8.27 ± 0.35
Frontal Lobe8.63 ± 0.33
Globus Pallidus8.76 ± 0.25
Hypothalamus8.63 ± 0.25
Insula8.62 ± 0.3
Limbic Lobe9.12 ± 0.35
Mesencephalon8.74 ± 0.31
Myelencephalon8.74 ± 0.3
Occipital Lobe9.02 ± 0.31
Parietal Lobe8.79 ± 0.38
Pontine Tegmentum8.81 ± 0.29
Striatum8.91 ± 0.33
Subthalamus8.53 ± 0.08
Temporal Lobe8.82 ± 0.31
Thalamus8.59 ± 0.27
White Matter9.08 ± 0.43
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Rnaseh1CBCerebellum8.99
12.32
Rnaseh1CTXCerebral cortex6.65
5.52
Rnaseh1HIPHippocampal region9.22
9.42
Rnaseh1HPFHippocampal formation7.44
6.95
Rnaseh1HYHypothalamus0.19
0.26
Rnaseh1LSXLateral septal complex0.08
0
Rnaseh1MBMidbrain2.44
2.87
Rnaseh1MYMedulla3.9
5.35
Rnaseh1OLFOlfactory bulb1.45
1.43
Rnaseh1PPons2.43
3.61
Rnaseh1PALPallidum0.18
0.26
Rnaseh1RHPRetrohippocampal region4.49
3.51
Rnaseh1sAMYStriatum-like amygdalar nuclei0.29
0.29
Rnaseh1STRStriatum0.39
0.35
Rnaseh1STRdStriatum dorsal region0.49
0.44
Rnaseh1STRvStriatum ventral region0.16
0.15
Rnaseh1THThalamus0.95
1.03
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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