AutismKB 2.0

Annotation Detail for ALPL


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Basic Information Top
Gene Symbol:ALPL ( AP-TNAP,APTNAP,FLJ40094,FLJ93059,HOPS,MGC161443,MGC167935,TNAP,TNSALP )
Gene Full Name: alkaline phosphatase, liver/bone/kidney
Band: 1p36.12
Quick LinksEntrez ID:249; OMIM: 171760; Uniprot ID:PPBT_HUMAN; ENSEMBL ID: ENSG00000162551; HGNC ID: 438
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst7 / 62319112
fetus9 / 56401215
neonate0 / 310970 
infant0 / 236200 
juvenile13 / 55556233
adult100 / 193912151
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor54 / 263845204
glioma3 / 10688328
head and neck tumor1 / 1363027
kidney tumor2 / 6895929
leukemia0 / 958420 
liver tumor7 / 9635972
lung tumor0 / 1031270 
lymphoma5 / 7175569
non-neoplasia3 / 9725030
normal178 / 336030752
ovarian tumor1 / 7668213
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS12 / 12568095
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue3 / 13106228
adrenal gland12 / 33197361
ascites0 / 400150 
bladder0 / 297570 
blood14 / 123478113
bone1 / 7165513
bone marrow0 / 488010 
brain44 / 110098939
cervix1 / 4817120
connective tissue4 / 14925526
ear0 / 162120 
embryonic tissue13 / 21572260
esophagus0 / 202090 
eye10 / 21105447
heart1 / 8962611
intestine1 / 2344724
kidney30 / 211777141
larynx0 / 241450 
liver14 / 20774367
lung16 / 33697447
lymph5 / 44270112
lymph node1 / 9161010
mammary gland5 / 15327132
mouth1 / 6705214
muscle0 / 1077150 
nerve3 / 15768190
ovary3 / 10205129
pancreas7 / 21481232
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta1 / 2808253
prostate6 / 18934531
salivary gland0 / 201550 
skin3 / 21057414
spleen6 / 53952111
stomach0 / 966190 
testis48 / 330442145
thymus0 / 811310 
thyroid2 / 4747342
tonsil0 / 169990 
trachea3 / 5241357
umbilical cord0 / 136800 
uterus6 / 23287825
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 215783_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts8
Adipocyte20.5
AdrenalCortex25.55
Adrenalgland30.25
Amygdala7.45
Appendix7.45
AtrioventricularNode5.7
BDCA4+_DentriticCells7
Bonemarrow7.6
BronchialEpithelialCells6.6
CD105+_Endothelial6.75
CD14+_Monocytes7.2
CD19+_BCells(neg._sel.)6.95
CD33+_Myeloid8.25
CD34+8.25
CD4+_Tcells7.05
CD56+_NKCells7.5
CD71+_EarlyErythroid6.5
CD8+_Tcells6.3
CardiacMyocytes9.05
Caudatenucleus6.15
Cerebellum5.7
CerebellumPeduncles7.9
CiliaryGanglion5.05
CingulateCortex7.05
Colorectaladenocarcinoma6.85
DorsalRootGanglion6
FetalThyroid6.65
Fetalbrain6.7
Fetalliver6
Fetallung5.85
GlobusPallidus5.35
Heart9.15
Hypothalamus7.25
Kidney27.55
Leukemia_chronicMyelogenousK-5626.25
Leukemia_promyelocytic-HL-606.05
Leukemialymphoblastic(MOLT-4)5.3
Liver21.4
Lung45.75
Lymphnode5.65
Lymphoma_burkitts(Daudi)8.95
Lymphoma_burkitts(Raji)10.05
MedullaOblongata6.05
OccipitalLobe6.2
OlfactoryBulb7.1
Ovary4.85
Pancreas5.8
PancreaticIslet7.2
ParietalLobe7.45
Pituitary8.15
Placenta7
Pons6.7
PrefrontalCortex8.65
Prostate7.9
Salivarygland6
SkeletalMuscle9.6
Skin6.6
SmoothMuscle7.7
Spinalcord7.4
SubthalamicNucleus6.35
SuperiorCervicalGanglion8.9
TemporalLobe6.5
Testis5.95
TestisGermCell5.7
TestisIntersitial5.75
TestisLeydigCell6.85
TestisSeminiferousTubule5.85
Thalamus7.05
Thymus5.1
Thyroid8.45
Tongue7.35
Tonsil6.75
Trachea9.65
TrigeminalGanglion7.75
Uterus5.4
UterusCorpus8.45
WholeBlood172.05
Wholebrain5.9
colon6.95
pineal_day8.32
pineal_night8.26
retina16.025
small_intestine6.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P97046
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.63 ± 1.08
Basal Forebrain1.94 ± 0.34
Basal Part of Pons2.55 ± 0.62
Cerebellar Cortex2.08 ± 0.69
Cerebellar Nuclei2.61 ± 0.67
Claustrum2.73 ± 0.78
Epithalamus2.31 ± 0.7
Frontal Lobe2.69 ± 0.81
Globus Pallidus2.36 ± 0.93
Hypothalamus2.57 ± 1.17
Insula2.64 ± 0.7
Limbic Lobe2.54 ± 0.71
Mesencephalon2.52 ± 0.76
Myelencephalon2.53 ± 0.92
Occipital Lobe1.85 ± 0.64
Parietal Lobe2.36 ± 0.87
Pontine Tegmentum2.58 ± 0.77
Striatum2.46 ± 0.92
Subthalamus2.9 ± 1.24
Temporal Lobe2.71 ± 0.72
Thalamus2.56 ± 0.7
White Matter1.48 ± 0.86
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Akp2CBCerebellum32.58
53.57
Akp2CTXCerebral cortex16.92
12.52
Akp2HIPHippocampal region12.9
12.61
Akp2HPFHippocampal formation19.36
17.62
Akp2HYHypothalamus3.45
2.5
Akp2LSXLateral septal complex2.55
3.39
Akp2MBMidbrain3.6
3.41
Akp2MYMedulla7.34
7.25
Akp2OLFOlfactory bulb25.43
21.88
Akp2PPons5.92
6.48
Akp2PALPallidum4.04
3.33
Akp2RHPRetrohippocampal region31.41
25.56
Akp2sAMYStriatum-like amygdalar nuclei15.32
11.63
Akp2STRStriatum13.54
10.41
Akp2STRdStriatum dorsal region14.41
11.14
Akp2STRvStriatum ventral region15.57
11.05
Akp2THThalamus2.69
2.75
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00011805 23 100 122 TYNTNAQVPDSAGTATAYLCGVK Peptide Atlas
PPBT_HUMAN_203 11 203 213 DIAYQLMHNIR PRIDE
PPBT_HUMAN_347 11 347 357 QALHEAVEMDR PRIDE
PPBT_HUMAN_53 19 53 71 NVIMFLGDGMGVSTVTAAR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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