AutismKB 2.0

Annotation Detail for ADAM2


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Basic Information Top
Gene Symbol:ADAM2 ( CRYN1,CRYN2,CT15,FTNB,PH-30b,PH30 )
Gene Full Name: ADAM metallopeptidase domain 2
Band: 8p11.22
Quick LinksEntrez ID:2515; OMIM: 601533; Uniprot ID:ADAM2_HUMAN; ENSEMBL ID: ENSG00000104755; HGNC ID: 198
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus0 / 5640120 
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult7 / 19391213
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal26 / 33603077
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain2 / 11009891
cervix0 / 481710 
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine0 / 2344720 
kidney0 / 2117770 
larynx0 / 241450 
liver0 / 2077430 
lung0 / 3369740 
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate2 / 18934510
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis36 / 330442108
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 207664_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.45
Adipocyte5.65
AdrenalCortex6.6
Adrenalgland5.1
Amygdala5.7
Appendix6.85
AtrioventricularNode7.35
BDCA4+_DentriticCells5.8
Bonemarrow6.1
BronchialEpithelialCells5.45
CD105+_Endothelial5.75
CD14+_Monocytes6.15
CD19+_BCells(neg._sel.)6.45
CD33+_Myeloid6.95
CD34+7.05
CD4+_Tcells6.15
CD56+_NKCells6.5
CD71+_EarlyErythroid5.45
CD8+_Tcells5.3
CardiacMyocytes8.35
Caudatenucleus5.15
Cerebellum4.7
CerebellumPeduncles6.8
CiliaryGanglion6.8
CingulateCortex5.95
Colorectaladenocarcinoma5.7
DorsalRootGanglion5.75
FetalThyroid6
Fetalbrain5.5
Fetalliver5.05
Fetallung4.65
GlobusPallidus4.45
Heart8.05
Hypothalamus6.2
Kidney5
Leukemia_chronicMyelogenousK-5625.2
Leukemia_promyelocytic-HL-605.05
Leukemialymphoblastic(MOLT-4)4.45
Liver8.15
Lung6.15
Lymphnode4.7
Lymphoma_burkitts(Daudi)7.5
Lymphoma_burkitts(Raji)8.5
MedullaOblongata5.15
OccipitalLobe5.1
OlfactoryBulb4.4
Ovary4.35
Pancreas4.7
PancreaticIslet6.25
ParietalLobe6.3
Pituitary6.6
Placenta5.6
Pons5.65
PrefrontalCortex6.85
Prostate6.55
Salivarygland4.75
SkeletalMuscle7.5
Skin6.35
SmoothMuscle6.4
Spinalcord6.1
SubthalamicNucleus5.4
SuperiorCervicalGanglion8.7
TemporalLobe5.3
Testis57.5
TestisGermCell57.55
TestisIntersitial84.15
TestisLeydigCell45.7
TestisSeminiferousTubule53
Thalamus6
Thymus4.3
Thyroid6.9
Tongue6
Tonsil5.65
Trachea4.7
TrigeminalGanglion8.75
Uterus4.5
UterusCorpus5.55
WholeBlood6.2
Wholebrain4.5
colon5.65
pineal_day7.02
pineal_night6.86
retina6.875
small_intestine5.4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_12648_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.04 ± 1.05
Basal Forebrain1.48 ± 0.23
Basal Part of Pons1.42 ± 0.45
Cerebellar Cortex1.71 ± 0.9
Cerebellar Nuclei1.96 ± 0.74
Claustrum2.53 ± 0.89
Epithalamus1.69 ± 0.75
Frontal Lobe1.61 ± 0.66
Globus Pallidus2.12 ± 0.32
Hypothalamus1.62 ± 0.62
Insula1.65 ± 0.72
Limbic Lobe1.81 ± 0.61
Mesencephalon1.93 ± 0.69
Myelencephalon1.77 ± 0.69
Occipital Lobe1.78 ± 0.61
Parietal Lobe1.78 ± 0.8
Pontine Tegmentum1.78 ± 0.67
Striatum1.81 ± 0.48
Subthalamus1.9 ± 0.66
Temporal Lobe1.66 ± 0.66
Thalamus1.77 ± 0.71
White Matter2.19 ± 0.3
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Adam2CBCerebellum1.44
2.25
Adam2CTXCerebral cortex1.12
1.16
Adam2HIPHippocampal region0.81
0.62
Adam2HPFHippocampal formation0.84
0.7
Adam2HYHypothalamus0.11
0.12
Adam2LSXLateral septal complex0.04
0
Adam2MBMidbrain0.28
0.43
Adam2MYMedulla0.49
0.47
Adam2OLFOlfactory bulb1.28
2.01
Adam2PPons0.27
0.36
Adam2PALPallidum0.23
0.16
Adam2RHPRetrohippocampal region0.87
0.81
Adam2sAMYStriatum-like amygdalar nuclei0.08
0.05
Adam2STRStriatum0.27
0.2
Adam2STRdStriatum dorsal region0.41
0.32
Adam2STRvStriatum ventral region0.06
0.03
Adam2THThalamus0.15
0.14
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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